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model_Isensee_JCB2018.xml
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<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version4" level="2" version="4">
<model metaid="Isensee_JCB2018" id="Isensee_JCB2018" name="Isensee_JCB2018">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<pre>PEtab implementation of the model from Isensee et al. (2018), The Journal of Cell Biology Jun 2018, 217 (6) 2167-2184</pre>
</body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#Isensee_JCB2018">
<dc:creator>
<rdf:Bag>
<rdf:li rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Isensee</vCard:Family>
<vCard:Given>Joerg</vCard:Given>
</vCard:N>
</rdf:li>
</rdf:Bag>
</dc:creator>
<dcterms:created rdf:parseType="Resource">
<dcterms:W3CDTF>2019-11-29T09:41:48Z</dcterms:W3CDTF>
</dcterms:created>
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2019-11-29T09:41:48Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/doi/10.1083/jcb.201708053"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
<listOfUnitDefinitions>
<unitDefinition metaid="time" id="time" name="time">
<listOfUnits>
<unit metaid="CDMT00162" kind="second" multiplier="60"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="substance" id="substance" name="substance">
<listOfUnits>
<unit metaid="CDMT00163" kind="mole"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="volume" id="volume" name="volume">
<listOfUnits>
<unit metaid="CDMT00164" kind="litre"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="area" id="area" name="area">
<listOfUnits>
<unit metaid="CDMT00165" kind="metre" exponent="2"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="length" id="length" name="length">
<listOfUnits>
<unit metaid="CDMT00166" kind="metre"/>
</listOfUnits>
</unitDefinition>
</listOfUnitDefinitions>
<listOfCompartments>
<compartment metaid="default" id="default" size="1" units="volume"/>
<compartment metaid="cyt" id="cyt" name="cyt" size="1" units="volume" outside="default"/>
<compartment metaid="nuc" id="nuc" name="nuc" size="1" units="volume" outside="default"/>
</listOfCompartments>
<listOfSpecies>
<species metaid="AC" id="AC" name="AC" compartment="cyt" initialConcentration="1"/>
<species metaid="pAC" id="pAC" name="pAC" compartment="cyt" initialConcentration="0"/>
<species metaid="AC_Fsk" id="AC_Fsk" name="AC:Fsk" compartment="cyt" initialConcentration="0"/>
<species metaid="pAC_Fsk" id="pAC_Fsk" name="pAC:Fsk" compartment="cyt" initialConcentration="0"/>
<species metaid="cAMP" id="cAMP" name="cAMP" compartment="cyt" initialConcentration="0.0575218758977949"/>
<species metaid="Csub" id="Csub" name="C" compartment="cyt" initialConcentration="0.192051405433538"/>
<species metaid="Csub_H89" id="Csub_H89" name="C:H89" compartment="cyt" initialConcentration="0"/>
<species metaid="RII_C_2" id="RII_C_2" name="RII_2:C_2" compartment="cyt" initialConcentration="0.514562213223039"/>
<species metaid="RIIp_C_2" id="RIIp_C_2" name="pRII_2:C_2" compartment="cyt" initialConcentration="0.287974352643203"/>
<species metaid="RIIp_cAMP_C_2" id="RIIp_cAMP_C_2" name="pRII_2:C_2:cAMP_4" compartment="cyt" initialConcentration="0.00541202870022029"/>
<species metaid="RIIp_cAMP_2" id="RIIp_cAMP_2" name="pRII_2:cAMP_4" compartment="cyt" initialConcentration="0.000400416634006059"/>
<species metaid="Sp8_Br_cAMPS" id="Sp8_Br_cAMPS" name="Sp8-Br-cAMPS" compartment="cyt" initialConcentration="0"/>
<species metaid="Rp8_Br_cAMPS" id="Rp8_Br_cAMPS" name="Rp-8-Br-cAMPS" compartment="cyt" initialConcentration="0"/>
<species metaid="Rp8_pCPT_cAMPS" id="Rp8_pCPT_cAMPS" name="Rp-8-pCPT-cAMPS" compartment="cyt" initialConcentration="0"/>
<species metaid="Rp_cAMPS" id="Rp_cAMPS" name="Rp-cAMPS" compartment="cyt" initialConcentration="0"/>
<species metaid="RIIp_Rp8_Br_cAMPS_C_2" id="RIIp_Rp8_Br_cAMPS_C_2" name="pRII_2:C_2:Rp-8-Br-cAMPS_4" compartment="cyt" initialConcentration="0"/>
<species metaid="RIIp_Rp8_pCPT_cAMPS_C_2" id="RIIp_Rp8_pCPT_cAMPS_C_2" name="pRII_2:C_2:Rp-8-pCPT-cAMPS_4" compartment="cyt" initialConcentration="0"/>
<species metaid="RIIp_Rp_cAMPS_C_2" id="RIIp_Rp_cAMPS_C_2" name="pRII_2:C_2:Rp-cAMPS_4" compartment="cyt" initialConcentration="0"/>
<species metaid="RIIp_Sp8_Br_cAMPS_C_2" id="RIIp_Sp8_Br_cAMPS_C_2" name="pRII_2:C_2:Sp-8-Br-cAMPS_4" compartment="cyt" initialConcentration="0"/>
<species metaid="RIIp_Sp8_Br_cAMPS_2" id="RIIp_Sp8_Br_cAMPS_2" name="pRII_2:Sp-8-Br-cAMPS_4" compartment="cyt" initialConcentration="0"/>
<species metaid="RIIp_2" id="RIIp_2" name="pRII_2" compartment="cyt" initialConcentration="0.133979505944916"/>
<species metaid="RII_2" id="RII_2" name="RII_2" compartment="cyt" initialConcentration="0.057671482854616"/>
<species metaid="IBMX" id="IBMX" name="IBMX" compartment="cyt" initialConcentration="0"/>
<species metaid="PDE" id="PDE" name="PDE" compartment="cyt" initialConcentration="1"/>
<species metaid="pPDE" id="pPDE" name="pPDE" compartment="cyt" initialConcentration="0"/>
</listOfSpecies>
<listOfParameters>
<parameter metaid="AC_total" id="AC_total" value="1"/>
<parameter metaid="KD_Fsk" id="KD_Fsk" value="14.2656743301721"/>
<parameter metaid="KD_H89" id="KD_H89" value="0.0480736009761681"/>
<parameter metaid="KD_IBMX" id="KD_IBMX" value="11.9768989891142"/>
<parameter metaid="KD_cAMP" id="KD_cAMP" value="2.84986906175302"/>
<parameter metaid="PDE_total" id="PDE_total" value="1"/>
<parameter metaid="RII2_total" id="RII2_total" value="1"/>
<parameter metaid="kdeg_cAMP" id="kdeg_cAMP" value="1.00032978441703e-05"/>
<parameter metaid="kdeg_cAMP_free" id="kdeg_cAMP_free" value="7.35892283451732"/>
<parameter metaid="kf_Fsk" id="kf_Fsk" value="999.991987450139"/>
<parameter metaid="kf_H89" id="kf_H89" value="0.000741493422675392"/>
<parameter metaid="kf_RII_2__RII_C_2" id="kf_RII_2__RII_C_2" value="1.26077939273477"/>
<parameter metaid="kf_RII_C_2__RII_2" id="kf_RII_C_2__RII_2" value="0.0187262534054505"/>
<parameter metaid="kf_RII_C_2__RIIp_C_2" id="kf_RII_C_2__RIIp_C_2" value="0.0227841500487899"/>
<parameter metaid="kf_RIIp_2__RII_2" id="kf_RIIp_2__RII_2" value="0.0323066621451248"/>
<parameter metaid="kf_RIIp_C_2__RII_C_2" id="kf_RIIp_C_2__RII_C_2" value="0.0256808704479994"/>
<parameter metaid="kf_RIIp_cAMP_C_2__RIIp_2" id="kf_RIIp_cAMP_C_2__RIIp_2" value="0.104924782853171"/>
<parameter metaid="kf_cAMP" id="kf_cAMP" value="0.49762030092122"/>
<parameter metaid="ki_IBMX" id="ki_IBMX" value="999.99999996515"/>
<parameter metaid="ki_Rp8_Br_cAMPS_pAB" id="ki_Rp8_Br_cAMPS_pAB" value="6.39991617125844"/>
<parameter metaid="ki_Rp8_pCPT_cAMPS_pAB" id="ki_Rp8_pCPT_cAMPS_pAB" value="9.24294887100985"/>
<parameter metaid="ki_Rp_cAMPS_pAB" id="ki_Rp_cAMPS_pAB" value="0.0163472838984393"/>
<parameter metaid="ki_Sp8_Br_cAMPS_AM" id="ki_Sp8_Br_cAMPS_AM" value="0.131083036712545"/>
<parameter metaid="ks_AC_cAMP" id="ks_AC_cAMP" value="0.423299046028554"/>
<parameter metaid="xi_AC_cAMP_Fsk" id="xi_AC_cAMP_Fsk" value="640.551657640036"/>
<parameter metaid="xi_b_Rp8_Br_cAMPS" id="xi_b_Rp8_Br_cAMPS" value="0.0408695544562406"/>
<parameter metaid="xi_b_Rp8_pCPT_cAMPS" id="xi_b_Rp8_pCPT_cAMPS" value="0.0268897774883765"/>
<parameter metaid="xi_b_Rp_cAMPS" id="xi_b_Rp_cAMPS" value="0.607960299288444"/>
<parameter metaid="xi_b_Sp8_Br_cAMPS" id="xi_b_Sp8_Br_cAMPS" value="21.7551956731725"/>
<parameter metaid="xi_kf_RII_2__RII_C_2" id="xi_kf_RII_2__RII_C_2" value="0.0189295042137343"/>
<parameter metaid="xi_kf_RII_C_2__RII_2" id="xi_kf_RII_C_2__RII_2" value="0.811223214879921"/>
<parameter metaid="Fsk" id="Fsk" value="10" units="time" constant="false"/>
<parameter metaid="IBMXex" id="IBMXex" value="0" constant="false"/>
<parameter metaid="H89" id="H89" value="0" constant="false"/>
<parameter metaid="Sp8_Br_cAMPS_AM" id="Sp8_Br_cAMPS_AM" value="0" constant="false"/>
<parameter metaid="Rp8_Br_cAMPS_pAB" id="Rp8_Br_cAMPS_pAB" value="0" constant="false"/>
<parameter metaid="Rp8_pCPT_cAMPS_pAB" id="Rp8_pCPT_cAMPS_pAB" value="0" constant="false"/>
<parameter metaid="Rp_cAMPS_pAB" id="Rp_cAMPS_pAB" value="0" constant="false"/>
<parameter metaid="fourABnOH" id="fourABnOH" value="0" constant="false"/>
<parameter metaid="Fsk_level" id="Fsk_level" value="0" units="substance"/>
<parameter metaid="Fsk_time" id="Fsk_time" value="0" units="time"/>
<parameter metaid="H89_level" id="H89_level" value="0" units="substance"/>
<parameter metaid="IBMX_level" id="IBMX_level" value="0" units="substance"/>
<parameter metaid="Rp8_Br_cAMPS_pAB_level" id="Rp8_Br_cAMPS_pAB_level" value="0" units="substance"/>
<parameter metaid="Rp8_Br_cAMPS_pAB_time" id="Rp8_Br_cAMPS_pAB_incubation_time" value="0" units="time"/>
<parameter metaid="H89_time" id="H89_time" value="0" units="time"/>
<parameter metaid="IBMX_time" id="IBMX_time" value="0" units="time"/>
<parameter metaid="Rp8_pCPT_cAMPS_pAB_level" id="Rp8_pCPT_cAMPS_pAB_level" value="0" units="substance"/>
<parameter metaid="Rp8_pCPT_cAMPS_pAB_time" id="Rp8_pCPT_cAMPS_pAB_incubation_time" value="0" units="time"/>
<parameter metaid="Rp_cAMPS_pAB_level" id="Rp_cAMPS_pAB_level" value="0" units="substance"/>
<parameter metaid="Rp_cAMPS_pAB_time" id="Rp_cAMPS_pAB_incubation_time" value="0" units="time"/>
<parameter metaid="Sp8_Br_cAMPS_AM_level" id="Sp8_Br_cAMPS_AM_level" value="0" units="substance"/>
<parameter metaid="Sp8_Br_cAMPS_AM_time" id="Sp8_Br_cAMPS_AM_time" value="0" units="time"/>
<parameter metaid="fourABnOH_level" id="fourABnOH_level" value="0" units="substance"/>
<parameter metaid="fourABnOH_time" id="fourABnOH_incubation_time" value="0" units="time"/>
<!-- H1: different KD -->
<parameter metaid="xi_KD_Rp8_Br_cAMPS" id="xi_KD_Rp8_Br_cAMPS" value="0"/>
<parameter metaid="xi_KD_Rp8_pCPT_cAMPS" id="xi_KD_Rp8_pCPT_cAMPS" value="0"/>
<parameter metaid="xi_KD_Rp_cAMPS" id="xi_KD_Rp_cAMPS" value="0"/>
<parameter metaid="xi_KD_Sp8_Br_cAMPS" id="xi_KD_Sp8_Br_cAMPS" value="0"/>
<!-- H2: AC inhibition -->
<parameter metaid="xi_pAC" id="xi_pAC" value="0"/>
<parameter metaid="kp_AC" id="kp_AC" value="0"/>
<parameter metaid="kdp_AC" id="kdp_AC" value="0"/>
<!-- H3: incomplete import -->
<parameter metaid="xi_i_Rp8_Br_cAMPS_pAB" id="xi_i_Rp8_Br_cAMPS_pAB" value="0"/>
<parameter metaid="xi_i_Rp8_pCPT_cAMPS_pAB" id="xi_i_Rp8_pCPT_cAMPS_pAB" value="0"/>
<parameter metaid="xi_i_Rp_cAMPS_pAB" id="xi_i_Rp_cAMPS_pAB" value="0"/>
<parameter metaid="xi_i_Sp8_Br_cAMPS_AM" id="xi_i_Sp8_Br_cAMPS_AM" value="0"/>
<!-- H4: PDE inhibition -->
<parameter metaid="xi_pPDE" id="xi_pPDE" value="0"/>
<parameter metaid="kf_PDE_Csub" id="kf_PDE_Csub" value="0"/>
<parameter metaid="KD_PDE_Csub" id="KD_PDE_Csub" value="0"/>
</listOfParameters>
<listOfRules>
<assignmentRule metaid="CDMT00167" variable="Fsk">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> Fsk_level </ci>
<piecewise>
<piece>
<cn type="integer"> 0 </cn>
<apply>
<lt/>
<apply>
<minus/>
<csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
<ci> Fsk_time </ci>
</apply>
<cn type="integer"> 0 </cn>
</apply>
</piece>
<otherwise>
<cn type="integer"> 1 </cn>
</otherwise>
</piecewise>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid="CDMT00170" variable="H89">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> H89_level </ci>
<piecewise>
<piece>
<cn type="integer"> 0 </cn>
<apply>
<lt/>
<apply>
<minus/>
<csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
<ci> H89_time </ci>
</apply>
<cn type="integer"> 0 </cn>
</apply>
</piece>
<otherwise>
<cn type="integer"> 1 </cn>
</otherwise>
</piecewise>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid="CDMT00168" variable="IBMXex">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> IBMX_level </ci>
<piecewise>
<piece>
<cn type="integer"> 0 </cn>
<apply>
<lt/>
<apply>
<minus/>
<csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
<ci> IBMX_time </ci>
</apply>
<cn type="integer"> 0 </cn>
</apply>
</piece>
<otherwise>
<cn type="integer"> 1 </cn>
</otherwise>
</piecewise>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid="CDMT00172" variable="Rp8_Br_cAMPS_pAB">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> Rp8_Br_cAMPS_pAB_level </ci>
<piecewise>
<piece>
<cn type="integer"> 0 </cn>
<apply>
<lt/>
<apply>
<minus/>
<csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
<ci> Rp8_Br_cAMPS_pAB_incubation_time </ci>
</apply>
<cn type="integer"> 0 </cn>
</apply>
</piece>
<otherwise>
<cn type="integer"> 1 </cn>
</otherwise>
</piecewise>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid="CDMT00173" variable="Rp8_pCPT_cAMPS_pAB">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> Rp8_pCPT_cAMPS_pAB_level </ci>
<piecewise>
<piece>
<cn type="integer"> 0 </cn>
<apply>
<lt/>
<apply>
<minus/>
<csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
<ci> Rp8_pCPT_cAMPS_pAB_incubation_time </ci>
</apply>
<cn type="integer"> 0 </cn>
</apply>
</piece>
<otherwise>
<cn type="integer"> 1 </cn>
</otherwise>
</piecewise>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid="CDMT00174" variable="Rp_cAMPS_pAB">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> Rp_cAMPS_pAB_level </ci>
<piecewise>
<piece>
<cn type="integer"> 0 </cn>
<apply>
<lt/>
<apply>
<minus/>
<csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
<ci> Rp_cAMPS_pAB_incubation_time </ci>
</apply>
<cn type="integer"> 0 </cn>
</apply>
</piece>
<otherwise>
<cn type="integer"> 1 </cn>
</otherwise>
</piecewise>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid="CDMT00171" variable="Sp8_Br_cAMPS_AM">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> Sp8_Br_cAMPS_AM_level </ci>
<piecewise>
<piece>
<cn type="integer"> 0 </cn>
<apply>
<lt/>
<apply>
<minus/>
<csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
<ci> Sp8_Br_cAMPS_AM_time </ci>
</apply>
<cn type="integer"> 0 </cn>
</apply>
</piece>
<otherwise>
<cn type="integer"> 1 </cn>
</otherwise>
</piecewise>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid="CDMT00175" variable="fourABnOH">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> fourABnOH_level </ci>
<piecewise>
<piece>
<cn type="integer"> 0 </cn>
<apply>
<lt/>
<apply>
<minus/>
<csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
<ci> fourABnOH_incubation_time </ci>
</apply>
<cn type="integer"> 0 </cn>
</apply>
</piece>
<otherwise>
<cn type="integer"> 1 </cn>
</otherwise>
</piecewise>
</apply>
</math>
</assignmentRule>
</listOfRules>
<listOfReactions>
<reaction metaid="v1_v_0" id="v1_v_0" name="v_0" reversible="false">
<listOfProducts>
<speciesReference metaid="CDMT00002" species="Sp8_Br_cAMPS"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00003" species="Sp8_Br_cAMPS"/>
</listOfModifiers>
<kineticLaw metaid="CDMT00004">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<apply>
<minus/>
<ci> ki_Sp8_Br_cAMPS_AM </ci>
</apply>
<apply>
<minus/>
<ci> Sp8_Br_cAMPS </ci>
<apply>
<times/>
<ci> Sp8_Br_cAMPS_AM </ci>
<ci> xi_i_Sp8_Br_cAMPS_AM </ci>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v2_v_1" id="v2_v_1" name="v_1" reversible="false">
<listOfProducts>
<speciesReference metaid="CDMT00006" species="Rp8_Br_cAMPS"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00007" species="Rp8_Br_cAMPS"/>
</listOfModifiers>
<kineticLaw metaid="CDMT00008">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<apply>
<minus/>
<ci> ki_Rp8_Br_cAMPS_pAB </ci>
</apply>
<apply>
<minus/>
<ci> Rp8_Br_cAMPS </ci>
<apply>
<times/>
<ci> Rp8_Br_cAMPS_pAB </ci>
<ci> xi_i_Rp8_Br_cAMPS_pAB </ci>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v3_v_2" id="v3_v_2" name="v_2" reversible="false">
<listOfProducts>
<speciesReference metaid="CDMT00010" species="Rp8_pCPT_cAMPS"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00011" species="Rp8_pCPT_cAMPS"/>
</listOfModifiers>
<kineticLaw metaid="CDMT00012">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<apply>
<minus/>
<ci> ki_Rp8_pCPT_cAMPS_pAB </ci>
</apply>
<apply>
<minus/>
<ci> Rp8_pCPT_cAMPS </ci>
<apply>
<times/>
<ci> Rp8_pCPT_cAMPS_pAB </ci>
<ci> xi_i_Rp8_pCPT_cAMPS_pAB </ci>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v4_v_3" id="v4_v_3" name="v_3" reversible="false">
<listOfProducts>
<speciesReference metaid="CDMT00014" species="Rp_cAMPS"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00015" species="Rp_cAMPS"/>
</listOfModifiers>
<kineticLaw metaid="CDMT00016">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<apply>
<minus/>
<ci> ki_Rp_cAMPS_pAB </ci>
</apply>
<apply>
<minus/>
<ci> Rp_cAMPS </ci>
<apply>
<times/>
<ci> Rp_cAMPS_pAB </ci>
<ci> xi_i_Rp_cAMPS_pAB </ci>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v5_v_4" id="v5_v_4" name="v_4" reversible="false">
<listOfProducts>
<speciesReference metaid="CDMT00018" species="IBMX"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00019" species="IBMX"/>
</listOfModifiers>
<kineticLaw metaid="CDMT00020">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<apply>
<minus/>
<ci> ki_IBMX </ci>
</apply>
<apply>
<minus/>
<ci> IBMX </ci>
<ci> IBMXex </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v6_v_5" id="v6_v_5" name="v_5" reversible="false">
<listOfReactants>
<speciesReference metaid="CDMT00021" species="AC"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00022" species="AC_Fsk"/>
</listOfProducts>
<kineticLaw metaid="CDMT00023">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> AC </ci>
<ci> Fsk </ci>
<ci> kf_Fsk </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v7_v_6" id="v7_v_6" name="v_6" reversible="false">
<listOfReactants>
<speciesReference metaid="CDMT00024" species="AC_Fsk"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00025" species="AC"/>
</listOfProducts>
<kineticLaw metaid="CDMT00026">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> AC_Fsk </ci>
<ci> KD_Fsk </ci>
<ci> kf_Fsk </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v8_v_7" id="v8_v_7" name="v_7" reversible="false">
<listOfReactants>
<speciesReference metaid="CDMT00027" species="pAC"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00028" species="pAC_Fsk"/>
</listOfProducts>
<kineticLaw metaid="CDMT00029">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> Fsk </ci>
<ci> kf_Fsk </ci>
<ci> pAC </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v9_v_8" id="v9_v_8" name="v_8" reversible="false">
<listOfReactants>
<speciesReference metaid="CDMT00030" species="pAC_Fsk"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00031" species="pAC"/>
</listOfProducts>
<kineticLaw metaid="CDMT00032">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> KD_Fsk </ci>
<ci> kf_Fsk </ci>
<ci> pAC_Fsk </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v10_v_9" id="v10_v_9" name="v_9" reversible="false">
<listOfReactants>
<speciesReference metaid="CDMT00033" species="AC"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00034" species="pAC"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00035" species="Csub"/>
</listOfModifiers>
<kineticLaw metaid="CDMT00036">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> AC </ci>
<ci> Csub </ci>
<ci> kp_AC </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v11_v_10" id="v11_v_10" name="v_10" reversible="false">
<listOfReactants>
<speciesReference metaid="CDMT00037" species="AC_Fsk"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00038" species="pAC_Fsk"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00039" species="Csub"/>
</listOfModifiers>
<kineticLaw metaid="CDMT00040">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> AC_Fsk </ci>
<ci> Csub </ci>
<ci> kp_AC </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v12_v_11" id="v12_v_11" name="v_11" reversible="false">
<listOfReactants>
<speciesReference metaid="CDMT00041" species="pAC"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00042" species="AC"/>
</listOfProducts>
<kineticLaw metaid="CDMT00043">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> kdp_AC </ci>
<ci> pAC </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v13_v_12" id="v13_v_12" name="v_12" reversible="false">
<listOfReactants>
<speciesReference metaid="CDMT00044" species="pAC_Fsk"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00045" species="AC_Fsk"/>
</listOfProducts>
<kineticLaw metaid="CDMT00046">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> kdp_AC </ci>
<ci> pAC_Fsk </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v14_v_13" id="v14_v_13" name="v_13" reversible="false">
<listOfProducts>
<speciesReference metaid="CDMT00048" species="cAMP"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00049" species="AC"/>
<modifierSpeciesReference metaid="CDMT00050" species="pAC"/>
</listOfModifiers>
<kineticLaw metaid="CDMT00051">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> ks_AC_cAMP </ci>
<apply>
<plus/>
<ci> AC </ci>
<apply>
<times/>
<ci> pAC </ci>
<ci> xi_pAC </ci>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v15_v_14" id="v15_v_14" name="v_14" reversible="false">
<listOfProducts>
<speciesReference metaid="CDMT00053" species="cAMP"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00054" species="AC_Fsk"/>
<modifierSpeciesReference metaid="CDMT00055" species="pAC_Fsk"/>
</listOfModifiers>
<kineticLaw metaid="CDMT00056">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> ks_AC_cAMP </ci>
<ci> xi_AC_cAMP_Fsk </ci>
<apply>
<plus/>
<ci> AC_Fsk </ci>
<apply>
<times/>
<ci> pAC_Fsk </ci>
<ci> xi_pAC </ci>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v16_v_15" id="v16_v_15" name="v_15" reversible="false">
<listOfReactants>
<speciesReference metaid="CDMT00057" species="cAMP"/>
</listOfReactants>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00059" species="IBMX"/>
<modifierSpeciesReference metaid="CDMT00060" species="PDE"/>
<modifierSpeciesReference metaid="CDMT00061" species="pPDE"/>
</listOfModifiers>
<kineticLaw metaid="CDMT00062">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<apply>
<divide/>
<apply>
<times/>
<ci> KD_IBMX </ci>
<ci> cAMP </ci>
<ci> kdeg_cAMP_free </ci>
<apply>
<plus/>
<ci> PDE </ci>
<apply>
<times/>
<ci> pPDE </ci>
<ci> xi_pPDE </ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci> IBMX </ci>
<ci> KD_IBMX </ci>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v17_v_16" id="v17_v_16" name="v_16" reversible="false">
<listOfReactants>
<speciesReference metaid="CDMT00063" species="RII_C_2"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00064" species="Csub"/>
<speciesReference metaid="CDMT00065" species="RII_2"/>
</listOfProducts>
<kineticLaw metaid="CDMT00066">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> RII_C_2 </ci>
<ci> kf_RII_C_2__RII_2 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v18_v_17" id="v18_v_17" name="v_17" reversible="false">
<listOfReactants>
<speciesReference metaid="CDMT00067" species="Csub"/>
<speciesReference metaid="CDMT00068" species="RII_2"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00069" species="RII_C_2"/>
</listOfProducts>
<kineticLaw metaid="CDMT00070">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> Csub </ci>
<ci> RII_2 </ci>
<ci> kf_RII_2__RII_C_2 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v19_v_18" id="v19_v_18" name="v_18" reversible="false">
<listOfReactants>
<speciesReference metaid="CDMT00071" species="RIIp_C_2"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00072" species="Csub"/>
<speciesReference metaid="CDMT00073" species="RIIp_2"/>
</listOfProducts>
<kineticLaw metaid="CDMT00074">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> RIIp_C_2 </ci>
<ci> kf_RII_C_2__RII_2 </ci>
<ci> xi_kf_RII_C_2__RII_2 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v20_v_19" id="v20_v_19" name="v_19" reversible="false">
<listOfReactants>
<speciesReference metaid="CDMT00075" species="Csub"/>
<speciesReference metaid="CDMT00076" species="RIIp_2"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00077" species="RIIp_C_2"/>
</listOfProducts>
<kineticLaw metaid="CDMT00078">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> Csub </ci>
<ci> RIIp_2 </ci>
<ci> kf_RII_2__RII_C_2 </ci>
<ci> xi_kf_RII_2__RII_C_2 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v21_v_20" id="v21_v_20" name="v_20" reversible="false">
<listOfReactants>
<speciesReference metaid="CDMT00079" species="RIIp_2"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00080" species="RII_2"/>
</listOfProducts>
<kineticLaw metaid="CDMT00081">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> RIIp_2 </ci>
<ci> kf_RIIp_2__RII_2 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v22_v_21" id="v22_v_21" name="v_21" reversible="false">
<listOfReactants>
<speciesReference metaid="CDMT00082" species="RII_C_2"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00083" species="RIIp_C_2"/>
</listOfProducts>
<kineticLaw metaid="CDMT00084">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> RII_C_2 </ci>
<ci> kf_RII_C_2__RIIp_C_2 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v23_v_22" id="v23_v_22" name="v_22" reversible="false">
<listOfReactants>
<speciesReference metaid="CDMT00085" species="RIIp_C_2"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00086" species="RII_C_2"/>
</listOfProducts>
<kineticLaw metaid="CDMT00087">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> RIIp_C_2 </ci>
<ci> kf_RIIp_C_2__RII_C_2 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v24_v_23" id="v24_v_23" name="v_23" reversible="false">
<listOfReactants>
<speciesReference metaid="CDMT00088" species="RIIp_C_2"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00089" species="RIIp_cAMP_C_2"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00090" species="cAMP"/>
</listOfModifiers>
<kineticLaw metaid="CDMT00091">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> RIIp_C_2 </ci>
<ci> cAMP </ci>
<ci> kf_cAMP </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v25_v_24" id="v25_v_24" name="v_24" reversible="false">
<listOfReactants>
<speciesReference metaid="CDMT00092" species="RIIp_cAMP_C_2"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00093" species="RIIp_C_2"/>
</listOfProducts>
<kineticLaw metaid="CDMT00094">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> KD_cAMP </ci>
<ci> RIIp_cAMP_C_2 </ci>
<ci> kf_cAMP </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v26_v_25" id="v26_v_25" name="v_25" reversible="false">
<listOfReactants>
<speciesReference metaid="CDMT00095" species="RIIp_cAMP_C_2"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00096" species="RIIp_C_2"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00097" species="IBMX"/>
<modifierSpeciesReference metaid="CDMT00098" species="PDE"/>
<modifierSpeciesReference metaid="CDMT00099" species="pPDE"/>
</listOfModifiers>
<kineticLaw metaid="CDMT00100">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<apply>
<divide/>
<apply>
<times/>
<ci> KD_IBMX </ci>
<ci> RIIp_cAMP_C_2 </ci>
<ci> kdeg_cAMP </ci>
<apply>
<plus/>
<ci> PDE </ci>
<apply>
<times/>
<ci> pPDE </ci>
<ci> xi_pPDE </ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci> IBMX </ci>
<ci> KD_IBMX </ci>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="v27_v_26" id="v27_v_26" name="v_26" reversible="false">
<listOfReactants>
<speciesReference metaid="CDMT00101" species="RIIp_cAMP_C_2"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00102" species="Csub"/>
<speciesReference metaid="CDMT00103" species="RIIp_cAMP_2"/>
</listOfProducts>
<kineticLaw metaid="CDMT00104">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> RIIp_cAMP_C_2 </ci>
<ci> kf_RIIp_cAMP_C_2__RIIp_2 </ci>
</apply>