diff --git a/RanDepict/randepict.py b/RanDepict/randepict.py
index 58eb1a0..100b039 100644
--- a/RanDepict/randepict.py
+++ b/RanDepict/randepict.py
@@ -313,7 +313,8 @@ def get_depiction_functions(self, smiles: str) -> List[Callable]:
 
         # Remove PIKAChU if there is an isotope
         if re.search("(\[\d\d\d?[A-Z])|(\[2H\])|(\[3H\])|(D)|(T)", smiles):
-            depiction_functions.remove(self.pikachu_depict)
+            if self.pikachu_depict in depiction_functions:
+                depiction_functions.remove(self.pikachu_depict)
         if self.has_r_group(smiles):
             # PIKAChU only accepts \[[RXZ]\d*\]
             squared_bracket_content = re.findall("\[.+?\]", smiles)