diff --git a/src/PKSim.Presentation/DTO/Simulations/SimulationIntervalDTO.cs b/src/PKSim.Presentation/DTO/Simulations/SimulationIntervalDTO.cs
deleted file mode 100644
index 1ad127c93..000000000
--- a/src/PKSim.Presentation/DTO/Simulations/SimulationIntervalDTO.cs
+++ /dev/null
@@ -1,62 +0,0 @@
-using OSPSuite.Core.Domain;
-using OSPSuite.Presentation.DTO;
-using OSPSuite.Utility.Validation;
-using PKSim.Assets;
-using PKSim.Presentation.DTO.Parameters;
-
-namespace PKSim.Presentation.DTO.Simulations
-{
-   public class SimulationIntervalDTO : ValidatableDTO
-   {
-      public OutputInterval SimulationInterval { get; set; }
-      public ParameterDTO StartTimeParameter { get; set; }
-      public ParameterDTO EndTimeParameter { get; set; }
-      public ParameterDTO ResolutionParameter { get; set; }
-
-      public SimulationIntervalDTO()
-      {
-         Rules.Add(startTimeLessThanEndTime);
-         Rules.Add(endTimeGreaterThanStartTime);
-      }
-
-      public double StartTime
-      {
-         get { return StartTimeParameter.Value; }
-         set { StartTimeParameter.Value = value; }
-      }
-
-      public double EndTime
-      {
-         get { return EndTimeParameter.Value; }
-         set { EndTimeParameter.Value = value; }
-      }
-
-      public double Resolution
-      {
-         get { return ResolutionParameter.Value; }
-         set { ResolutionParameter.Value = value; }
-      }
-
-      private IBusinessRule startTimeLessThanEndTime
-      {
-         get
-         {
-            return CreateRule.For<SimulationIntervalDTO>()
-               .Property(x => x.StartTime)
-               .WithRule((dto, value) => StartTimeParameter.Parameter.ConvertToBaseUnit(value) < EndTimeParameter.KernelValue)
-               .WithError(PKSimConstants.Rules.Parameter.StartTimeLessThanOrEqualToEndTime);
-         }
-      }
-
-      private IBusinessRule endTimeGreaterThanStartTime
-      {
-         get
-         {
-            return CreateRule.For<SimulationIntervalDTO>()
-               .Property(x => x.EndTime)
-               .WithRule((dto, value) => EndTimeParameter.Parameter.ConvertToBaseUnit(value) > StartTimeParameter.KernelValue)
-               .WithError(PKSimConstants.Rules.Parameter.EndTimeGreaterThanOrEqualToStartTime);
-         }
-      }
-   }
-}
\ No newline at end of file
diff --git a/src/PKSim.UI/Views/Compounds/CompoundParameterWithDefaultAlternativeBaseView.cs b/src/PKSim.UI/Views/Compounds/CompoundParameterWithDefaultAlternativeBaseView.cs
index 7ed4e762b..211b76515 100644
--- a/src/PKSim.UI/Views/Compounds/CompoundParameterWithDefaultAlternativeBaseView.cs
+++ b/src/PKSim.UI/Views/Compounds/CompoundParameterWithDefaultAlternativeBaseView.cs
@@ -111,7 +111,13 @@ protected override bool ColumnIsButton(GridColumn column)
       {
          return Equals(_colButtons?.XtraColumn, column);
       }
-      
+
+
+      protected override bool ColumnIsCheckBox(GridColumn column)
+      {
+         return Equals(_colDefault?.XtraColumn, column);
+      }
+
       public override void InitializeResources()
       {
          base.InitializeResources();
diff --git a/src/PKSim.UI/Views/Core/BaseUserControlWithValueInGrid.cs b/src/PKSim.UI/Views/Core/BaseUserControlWithValueInGrid.cs
index 689e9ee22..05480c15d 100644
--- a/src/PKSim.UI/Views/Core/BaseUserControlWithValueInGrid.cs
+++ b/src/PKSim.UI/Views/Core/BaseUserControlWithValueInGrid.cs
@@ -40,6 +40,12 @@ protected virtual void OnGridViewMouseDown(UxGridView gridView, MouseEventArgs e
             return;
          }
 
+         if (ColumnIsCheckBox(col))
+         {
+            RaiseCheckEditClick(gridView, col, rowHandle, e);
+            return;
+         }
+
          if (!ColumnIsValue(col))
          {
             gridView.EditorShowMode = EditorShowMode.Default;
@@ -65,14 +71,24 @@ protected virtual void RaiseButtonClick(UxGridView gridView, GridColumn column,
             edit.PerformClick(ehi.HitObject.DowncastTo<EditorButtonObjectInfoArgs>().Button);
             ((DXMouseEventArgs)e).Handled = true;
          }
-         return;
       }
 
-      protected virtual bool ColumnIsButton(GridColumn column)
+      protected virtual void RaiseCheckEditClick(UxGridView gridView, GridColumn column, int rowHandle, MouseEventArgs e)
       {
-         return false;
+         //Adapted from https://supportcenter.devexpress.com/ticket/details/t230842/grid-the-buttonclick-event-is-not-raised-immediately-when-multi-selection-is-enabled
+         gridView.FocusedRowHandle = rowHandle;
+         gridView.FocusedColumn = column;
+         gridView.ShowEditor();
+         //force button click  
+         var edit = gridView.ActiveEditor.DowncastTo<CheckEdit>();
+         edit.Toggle();
+         ((DXMouseEventArgs) e).Handled = true;
       }
-      
+
+      protected virtual bool ColumnIsButton(GridColumn column) => false;
+
+      protected virtual bool ColumnIsCheckBox(GridColumn column) => false;
+
       protected virtual void OnValueColumnMouseDown(UxGridView gridView, GridColumn col, int rowHandle)
       {
          gridView.EditorShowMode = EditorShowMode.MouseUp;