Final Report

[nicola-calonaci]

Generate a multi-page pdf presenting the main plots with a nice panel arrangement.

• Quality Control @vvvirgy @valerianilucrezia

  • One page per sample with usual CNAqc report
  • One page per patient with aggregated data from multiple samples (e.g. comparison of CNV profiles, drivers VAF)

• Subclonal Deconvolution @giorgiagandolfi @elena-buscaroli @nicola-calonaci (one page per patient with usual CNAqc report)

  • Univariate
    • One page per sample with deconvolution including driver labels, plus distribution of the mutation rate (boxplot or other)
  • Multivariate
    • One page per patient with 2D deconvolution plus 1D coloured by 2D clusters
  • Clone trees

• Signature Deconvolution @elena-buscaroli

  • One page per dataset with model selection metrics, signature profiles and patients exposures

• Mafplot @giorgiagandolfi @nicola-calonaci

  • One page per dataset oncoplot with the following annotations:
    • Driver mutations
    • CNV state
    • Clonal/Subclonal and VAF
    • Signature Exposure
  • One page per dataset maf summary

• Cohort-level statistics @nicola-calonaci

  • Summary clonal architecture
  • dnds #48
  • Evolutionary trajectories