diff --git a/cellxgene_schema_cli/requirements.txt b/cellxgene_schema_cli/requirements.txt
index ff4011630..e7328b7af 100644
--- a/cellxgene_schema_cli/requirements.txt
+++ b/cellxgene_schema_cli/requirements.txt
@@ -1,10 +1,8 @@
 anndata>=0.8.0,<0.11
 cellxgene-ontology-guide==1.3.0 # update before a schema migration
 click<9
-Cython<4
 numpy<2
 pandas>2,<3
-PyYAML<7
 scipy<1.15 # broken in 1.15.0 see https://github.com/chanzuckerberg/single-cell-curation/issues/1165
 semver<4
 xxhash<4