diff --git a/.github/workflows/deploy.yml b/.github/workflows/deploy.yml
index 26d2a5e0..83e7b32f 100644
--- a/.github/workflows/deploy.yml
+++ b/.github/workflows/deploy.yml
@@ -36,7 +36,7 @@ jobs:
     name: Publish 🗞
     runs-on: ubuntu-latest
     container:
-      image: ghcr.io/insightsengineering/rstudio:2024.03.05
+      image: ghcr.io/insightsengineering/rstudio:2024.10.15
     if: >
       !contains(github.event.commits[0].message, '[skip deploy]')
     strategy:
diff --git a/RNA-seq/renv.lock b/RNA-seq/renv.lock
index 58575660..17288c89 100644
--- a/RNA-seq/renv.lock
+++ b/RNA-seq/renv.lock
@@ -1,26 +1,26 @@
 {
   "R": {
-    "Version": "4.3.2",
+    "Version": "4.4.1",
     "Repositories": [
       {
         "Name": "BioCsoft",
-        "URL": "https://bioconductor.org/packages/3.18/bioc"
+        "URL": "https://bioconductor.org/packages/3.19/bioc"
       },
       {
         "Name": "BioCann",
-        "URL": "https://bioconductor.org/packages/3.18/data/annotation"
+        "URL": "https://bioconductor.org/packages/3.19/data/annotation"
       },
       {
         "Name": "BioCexp",
-        "URL": "https://bioconductor.org/packages/3.18/data/experiment"
+        "URL": "https://bioconductor.org/packages/3.19/data/experiment"
       },
       {
         "Name": "BioCworkflows",
-        "URL": "https://bioconductor.org/packages/3.18/workflows"
+        "URL": "https://bioconductor.org/packages/3.19/workflows"
       },
       {
         "Name": "BioCbooks",
-        "URL": "https://bioconductor.org/packages/3.18/books"
+        "URL": "https://bioconductor.org/packages/3.19/books"
       },
       {
         "Name": "CRAN",
@@ -28,23 +28,23 @@
       },
       {
         "Name": "BioC.BioCsoft",
-        "URL": "https://bioconductor.org/packages/3.18/bioc"
+        "URL": "https://bioconductor.org/packages/3.19/bioc"
       },
       {
         "Name": "BioC.BioCann",
-        "URL": "https://bioconductor.org/packages/3.18/data/annotation"
+        "URL": "https://bioconductor.org/packages/3.19/data/annotation"
       },
       {
         "Name": "BioC.BioCexp",
-        "URL": "https://bioconductor.org/packages/3.18/data/experiment"
+        "URL": "https://bioconductor.org/packages/3.19/data/experiment"
       },
       {
         "Name": "BioC.BioCworkflows",
-        "URL": "https://bioconductor.org/packages/3.18/workflows"
+        "URL": "https://bioconductor.org/packages/3.19/workflows"
       },
       {
         "Name": "BioC.BioCbooks",
-        "URL": "https://bioconductor.org/packages/3.18/books"
+        "URL": "https://bioconductor.org/packages/3.19/books"
       },
       {
         "Name": "BioC.CRAN",
@@ -53,7 +53,7 @@
     ]
   },
   "Bioconductor": {
-    "Version": "3.18"
+    "Version": "3.19"
   },
   "Packages": {
     "AnnotationDbi": {
@@ -109,7 +109,7 @@
       "Package": "BiocFileCache",
       "Version": "2.10.2",
       "Source": "Bioconductor",
-      "Repository": "Bioconductor 3.18",
+      "Repository": "Bioconductor 3.19",
       "Requirements": [
         "DBI",
         "R",
@@ -179,7 +179,7 @@
       "Package": "Biostrings",
       "Version": "2.70.3",
       "Source": "Bioconductor",
-      "Repository": "Bioconductor 3.18",
+      "Repository": "Bioconductor 3.19",
       "Requirements": [
         "BiocGenerics",
         "GenomeInfoDb",
@@ -238,7 +238,7 @@
       "Package": "DESeq2",
       "Version": "1.42.1",
       "Source": "Bioconductor",
-      "Repository": "Bioconductor 3.18",
+      "Repository": "Bioconductor 3.19",
       "Requirements": [
         "Biobase",
         "BiocGenerics",
@@ -332,7 +332,7 @@
       "Package": "GenomeInfoDb",
       "Version": "1.38.8",
       "Source": "Bioconductor",
-      "Repository": "Bioconductor 3.18",
+      "Repository": "Bioconductor 3.19",
       "Requirements": [
         "BiocGenerics",
         "GenomeInfoDbData",
@@ -665,7 +665,7 @@
       "Package": "S4Arrays",
       "Version": "1.2.1",
       "Source": "Bioconductor",
-      "Repository": "Bioconductor 3.18",
+      "Repository": "Bioconductor 3.19",
       "Requirements": [
         "BiocGenerics",
         "IRanges",
@@ -681,9 +681,9 @@
     },
     "S4Vectors": {
       "Package": "S4Vectors",
-      "Version": "0.40.2",
+      "Version": "0.42.1",
       "Source": "Bioconductor",
-      "Repository": "Bioconductor 3.18",
+      "Repository": "Bioconductor 3.19",
       "Requirements": [
         "BiocGenerics",
         "R",
@@ -692,13 +692,13 @@
         "stats4",
         "utils"
       ],
-      "Hash": "1716e201f81ced0f456dd5ec85fe20f8"
+      "Hash": "86398fc7c5f6be4ba29fe23ed08c2da6"
     },
     "SparseArray": {
       "Package": "SparseArray",
       "Version": "1.2.4",
       "Source": "Bioconductor",
-      "Repository": "Bioconductor 3.18",
+      "Repository": "Bioconductor 3.19",
       "Requirements": [
         "BiocGenerics",
         "IRanges",
@@ -835,7 +835,7 @@
       "Package": "biomaRt",
       "Version": "2.58.2",
       "Source": "Bioconductor",
-      "Repository": "Bioconductor 3.18",
+      "Repository": "Bioconductor 3.19",
       "Requirements": [
         "AnnotationDbi",
         "BiocFileCache",
@@ -1273,7 +1273,7 @@
       "Package": "edgeR",
       "Version": "4.0.16",
       "Source": "Bioconductor",
-      "Repository": "Bioconductor 3.18",
+      "Repository": "Bioconductor 3.19",
       "Requirements": [
         "R",
         "Rcpp",
@@ -3358,7 +3358,7 @@
       "Package": "zlibbioc",
       "Version": "1.48.2",
       "Source": "Bioconductor",
-      "Repository": "Bioconductor 3.18",
+      "Repository": "Bioconductor 3.19",
       "Hash": "2344be62c2da4d9e9942b5d8db346e59"
     }
   }
diff --git a/early-dev/renv.lock b/early-dev/renv.lock
index 2571059a..af9c6ab8 100644
--- a/early-dev/renv.lock
+++ b/early-dev/renv.lock
@@ -1,26 +1,26 @@
 {
   "R": {
-    "Version": "4.3.2",
+    "Version": "4.4.1",
     "Repositories": [
       {
         "Name": "BioCsoft",
-        "URL": "https://bioconductor.org/packages/3.17/bioc"
+        "URL": "https://bioconductor.org/packages/3.19/bioc"
       },
       {
         "Name": "BioCann",
-        "URL": "https://bioconductor.org/packages/3.17/data/annotation"
+        "URL": "https://bioconductor.org/packages/3.19/data/annotation"
       },
       {
         "Name": "BioCexp",
-        "URL": "https://bioconductor.org/packages/3.17/data/experiment"
+        "URL": "https://bioconductor.org/packages/3.19/data/experiment"
       },
       {
         "Name": "BioCworkflows",
-        "URL": "https://bioconductor.org/packages/3.17/workflows"
+        "URL": "https://bioconductor.org/packages/3.19/workflows"
       },
       {
         "Name": "BioCbooks",
-        "URL": "https://bioconductor.org/packages/3.17/books"
+        "URL": "https://bioconductor.org/packages/3.19/books"
       },
       {
         "Name": "RSPM",
diff --git a/efficacy/renv.lock b/efficacy/renv.lock
index f71de6c5..461193dc 100644
--- a/efficacy/renv.lock
+++ b/efficacy/renv.lock
@@ -4,23 +4,23 @@
     "Repositories": [
       {
         "Name": "BioCsoft",
-        "URL": "https://bioconductor.org/packages/3.17/bioc"
+        "URL": "https://bioconductor.org/packages/3.19/bioc"
       },
       {
         "Name": "BioCann",
-        "URL": "https://bioconductor.org/packages/3.17/data/annotation"
+        "URL": "https://bioconductor.org/packages/3.19/data/annotation"
       },
       {
         "Name": "BioCexp",
-        "URL": "https://bioconductor.org/packages/3.17/data/experiment"
+        "URL": "https://bioconductor.org/packages/3.19/data/experiment"
       },
       {
         "Name": "BioCworkflows",
-        "URL": "https://bioconductor.org/packages/3.17/workflows"
+        "URL": "https://bioconductor.org/packages/3.19/workflows"
       },
       {
         "Name": "BioCbooks",
-        "URL": "https://bioconductor.org/packages/3.17/books"
+        "URL": "https://bioconductor.org/packages/3.19/books"
       },
       {
         "Name": "RSPM",
diff --git a/exploratory/renv.lock b/exploratory/renv.lock
index 9e823d4b..cc1a145b 100644
--- a/exploratory/renv.lock
+++ b/exploratory/renv.lock
@@ -4,23 +4,23 @@
     "Repositories": [
       {
         "Name": "BioCsoft",
-        "URL": "https://bioconductor.org/packages/3.18/bioc"
+        "URL": "https://bioconductor.org/packages/3.19/bioc"
       },
       {
         "Name": "BioCann",
-        "URL": "https://bioconductor.org/packages/3.18/data/annotation"
+        "URL": "https://bioconductor.org/packages/3.19/data/annotation"
       },
       {
         "Name": "BioCexp",
-        "URL": "https://bioconductor.org/packages/3.18/data/experiment"
+        "URL": "https://bioconductor.org/packages/3.19/data/experiment"
       },
       {
         "Name": "BioCworkflows",
-        "URL": "https://bioconductor.org/packages/3.18/workflows"
+        "URL": "https://bioconductor.org/packages/3.19/workflows"
       },
       {
         "Name": "BioCbooks",
-        "URL": "https://bioconductor.org/packages/3.18/books"
+        "URL": "https://bioconductor.org/packages/3.19/books"
       },
       {
         "Name": "RSPM",
diff --git a/longitudinal/renv.lock b/longitudinal/renv.lock
index eead87a6..7bb34f39 100644
--- a/longitudinal/renv.lock
+++ b/longitudinal/renv.lock
@@ -1,26 +1,26 @@
 {
   "R": {
-    "Version": "4.3.2",
+    "Version": "4.4.1",
     "Repositories": [
       {
         "Name": "BioCsoft",
-        "URL": "https://bioconductor.org/packages/3.18/bioc"
+        "URL": "https://bioconductor.org/packages/3.19/bioc"
       },
       {
         "Name": "BioCann",
-        "URL": "https://bioconductor.org/packages/3.18/data/annotation"
+        "URL": "https://bioconductor.org/packages/3.19/data/annotation"
       },
       {
         "Name": "BioCexp",
-        "URL": "https://bioconductor.org/packages/3.18/data/experiment"
+        "URL": "https://bioconductor.org/packages/3.19/data/experiment"
       },
       {
         "Name": "BioCworkflows",
-        "URL": "https://bioconductor.org/packages/3.18/workflows"
+        "URL": "https://bioconductor.org/packages/3.19/workflows"
       },
       {
         "Name": "BioCbooks",
-        "URL": "https://bioconductor.org/packages/3.18/books"
+        "URL": "https://bioconductor.org/packages/3.19/books"
       },
       {
         "Name": "RSPM",
diff --git a/patient-profile/renv.lock b/patient-profile/renv.lock
index 3b033737..502c16c3 100644
--- a/patient-profile/renv.lock
+++ b/patient-profile/renv.lock
@@ -4,23 +4,23 @@
     "Repositories": [
       {
         "Name": "BioCsoft",
-        "URL": "https://bioconductor.org/packages/3.17/bioc"
+        "URL": "https://bioconductor.org/packages/3.19/bioc"
       },
       {
         "Name": "BioCann",
-        "URL": "https://bioconductor.org/packages/3.17/data/annotation"
+        "URL": "https://bioconductor.org/packages/3.19/data/annotation"
       },
       {
         "Name": "BioCexp",
-        "URL": "https://bioconductor.org/packages/3.17/data/experiment"
+        "URL": "https://bioconductor.org/packages/3.19/data/experiment"
       },
       {
         "Name": "BioCworkflows",
-        "URL": "https://bioconductor.org/packages/3.17/workflows"
+        "URL": "https://bioconductor.org/packages/3.19/workflows"
       },
       {
         "Name": "BioCbooks",
-        "URL": "https://bioconductor.org/packages/3.17/books"
+        "URL": "https://bioconductor.org/packages/3.19/books"
       },
       {
         "Name": "RSPM",
diff --git a/python/renv.lock b/python/renv.lock
index 4102820f..f7f9faf2 100644
--- a/python/renv.lock
+++ b/python/renv.lock
@@ -4,23 +4,23 @@
     "Repositories": [
       {
         "Name": "BioCsoft",
-        "URL": "https://bioconductor.org/packages/3.17/bioc"
+        "URL": "https://bioconductor.org/packages/3.19/bioc"
       },
       {
         "Name": "BioCann",
-        "URL": "https://bioconductor.org/packages/3.17/data/annotation"
+        "URL": "https://bioconductor.org/packages/3.19/data/annotation"
       },
       {
         "Name": "BioCexp",
-        "URL": "https://bioconductor.org/packages/3.17/data/experiment"
+        "URL": "https://bioconductor.org/packages/3.19/data/experiment"
       },
       {
         "Name": "BioCworkflows",
-        "URL": "https://bioconductor.org/packages/3.17/workflows"
+        "URL": "https://bioconductor.org/packages/3.19/workflows"
       },
       {
         "Name": "BioCbooks",
-        "URL": "https://bioconductor.org/packages/3.17/books"
+        "URL": "https://bioconductor.org/packages/3.19/books"
       },
       {
         "Name": "RSPM",
diff --git a/safety/renv.lock b/safety/renv.lock
index a055c14d..fabc92f9 100644
--- a/safety/renv.lock
+++ b/safety/renv.lock
@@ -4,23 +4,23 @@
     "Repositories": [
       {
         "Name": "BioCsoft",
-        "URL": "https://bioconductor.org/packages/3.18/bioc"
+        "URL": "https://bioconductor.org/packages/3.19/bioc"
       },
       {
         "Name": "BioCann",
-        "URL": "https://bioconductor.org/packages/3.18/data/annotation"
+        "URL": "https://bioconductor.org/packages/3.19/data/annotation"
       },
       {
         "Name": "BioCexp",
-        "URL": "https://bioconductor.org/packages/3.18/data/experiment"
+        "URL": "https://bioconductor.org/packages/3.19/data/experiment"
       },
       {
         "Name": "BioCworkflows",
-        "URL": "https://bioconductor.org/packages/3.18/workflows"
+        "URL": "https://bioconductor.org/packages/3.19/workflows"
       },
       {
         "Name": "BioCbooks",
-        "URL": "https://bioconductor.org/packages/3.18/books"
+        "URL": "https://bioconductor.org/packages/3.19/books"
       },
       {
         "Name": "RSPM",