diff --git a/Modules/Scripted/SampleData/SampleData.py b/Modules/Scripted/SampleData/SampleData.py
index 9d18ed77980..6a5d20c21c0 100644
--- a/Modules/Scripted/SampleData/SampleData.py
+++ b/Modules/Scripted/SampleData/SampleData.py
@@ -269,6 +269,27 @@ def setup(self):
         if self.developerMode is False:
             self.setCategoryVisible(self.logic.developmentCategoryName, False)
 
+        customFrame = ctk.ctkCollapsibleGroupBox()
+        self.categoryLayout.addWidget(customFrame)
+        customFrame.title = _("Custom data download")
+        customFrameLayout = qt.QHBoxLayout()
+        customFrame.setLayout(customFrameLayout)
+        self.customSampleLabel = qt.QLabel(_("URL:"))
+        customFrameLayout.addWidget(self.customSampleLabel)
+        self.customSampleName = qt.QLineEdit()
+        customFrameLayout.addWidget(self.customSampleName)
+        self.customDownloadButton = qt.QPushButton(_("Load"))
+        self.customDownloadButton.toolTip = _("Download the dataset from the given URL and import it into the scene")
+        self.customDownloadButton.default = True
+        customFrameLayout.addWidget(self.customDownloadButton)
+        self.showCustomDataFolderButton = qt.QPushButton(_("Show folder"))
+        self.showCustomDataFolderButton.toolTip = _("Show folder where custom data sets are downloaded ({path}).").format(path=slicer.app.cachePath)
+        customFrameLayout.addWidget(self.showCustomDataFolderButton)
+        customFrame.collapsed = True
+        self.customSampleName.connect("returnPressed()", self.onCustomDataDownload)
+        self.customDownloadButton.connect("clicked()", self.onCustomDataDownload)
+        self.showCustomDataFolderButton.connect("clicked()", self.onShowCustomDataFolder)
+
         self.log = qt.QTextEdit()
         self.log.readOnly = True
         self.layout.addWidget(self.log)
@@ -279,6 +300,12 @@ def setup(self):
     def cleanup(self):
         SampleDataWidget.setCategoriesFromSampleDataSources(self.categoryLayout, {}, self.logic)
 
+    def onCustomDataDownload(self):
+        self.logic.downloadFromURL(self.customSampleName.text)
+
+    def onShowCustomDataFolder(self):
+        qt.QDesktopServices.openUrl(qt.QUrl("file:///" + slicer.app.cachePath, qt.QUrl.TolerantMode))
+
     @staticmethod
     def removeCategories(categoryLayout):
         """Remove all categories from the given category layout."""
@@ -676,6 +703,17 @@ def downloadFromSource(self, source, maximumAttemptsCount=3):
         for uri, fileName, nodeName, checksum, loadFile, loadFileType in zip(
             source.uris, source.fileNames, source.nodeNames, source.checksums, source.loadFiles, source.loadFileTypes):
 
+            if nodeName is None or fileName is None:
+                import urllib
+                import uuid
+                p = urllib.parse.urlparse(uri)
+                basename, ext = os.path.splitext(os.path.basename(p.path))
+                if nodeName is None:
+                    nodeName = basename
+                if fileName is None:
+                    # Generate a unique filename to avoid overwriting existing file with the same name
+                    fileName = f"{nodeName}-{uuid.uuid4().hex}{ext}"
+
             current_source = SampleDataSource(
                 uris=uri,
                 fileNames=fileName,