04DifferentialExpression.slides.html


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  content: "\00a5";
}
.glyphicon-jpy:before {
  content: "\00a5";
}
.glyphicon-ruble:before {
  content: "\20bd";
}
.glyphicon-rub:before {
  content: "\20bd";
}
.glyphicon-scale:before {
  content: "\e230";
}
.glyphicon-ice-lolly:before {
  content: "\e231";
}
.glyphicon-ice-lolly-tasted:before {
  content: "\e232";
}
.glyphicon-education:before {
  content: "\e233";
}
.glyphicon-option-horizontal:before {
  content: "\e234";
}
.glyphicon-option-vertical:before {
  content: "\e235";
}
.glyphicon-menu-hamburger:before {
  content: "\e236";
}
.glyphicon-modal-window:before {
  content: "\e237";
}
.glyphicon-oil:before {
  content: "\e238";
}
.glyphicon-grain:before {
  content: "\e239";
}
.glyphicon-sunglasses:before {
  content: "\e240";
}
.glyphicon-text-size:before {
  content: "\e241";
}
.glyphicon-text-color:before {
  content: "\e242";
}
.glyphicon-text-background:before {
  content: "\e243";
}
.glyphicon-object-align-top:before {
  content: "\e244";
}
.glyphicon-object-align-bottom:before {
  content: "\e245";
}
.glyphicon-object-align-horizontal:before {
  content: "\e246";
}
.glyphicon-object-align-left:before {
  content: "\e247";
}
.glyphicon-object-align-vertical:before {
  content: "\e248";
}
.glyphicon-object-align-right:before {
  content: "\e249";
}
.glyphicon-triangle-right:before {
  content: "\e250";
}
.glyphicon-triangle-left:before {
  content: "\e251";
}
.glyphicon-triangle-bottom:before {
  content: "\e252";
}
.glyphicon-triangle-top:before {
  content: "\e253";
}
.glyphicon-console:before {
  content: "\e254";
}
.glyphicon-superscript:before {
  content: "\e255";
}
.glyphicon-subscript:before {
  content: "\e256";
}
.glyphicon-menu-left:before {
  content: "\e257";
}
.glyphicon-menu-right:before {
  content: "\e258";
}
.glyphicon-menu-down:before {
  content: "\e259";
}
.glyphicon-menu-up:before {
  content: "\e260";
}
* {
  -webkit-box-sizing: border-box;
  -moz-box-sizing: border-box;
  box-sizing: border-box;
}
*:before,
*:after {
  -webkit-box-sizing: border-box;
  -moz-box-sizing: border-box;
  box-sizing: border-box;
}
html {
  font-size: 10px;
  -webkit-tap-highlight-color: rgba(0, 0, 0, 0);
}
body {
  font-family: "Helvetica Neue", Helvetica, Arial, sans-serif;
  font-size: 13px;
  line-height: 1.42857143;
  color: #000;
  background-color: #fff;
}
input,
button,
select,
textarea {
  font-family: inherit;
  font-size: inherit;
  line-height: inherit;
}
a {
  color: #337ab7;
  text-decoration: none;
}
a:hover,
a:focus {
  color: #23527c;
  text-decoration: underline;
}
a:focus {
  outline: 5px auto -webkit-focus-ring-color;
  outline-offset: -2px;
}
figure {
  margin: 0;
}
img {
  vertical-align: middle;
}
.img-responsive,
.thumbnail > img,
.thumbnail a > img,
.carousel-inner > .item > img,
.carousel-inner > .item > a > img {
  display: block;
  max-width: 100%;
  height: auto;
}
.img-rounded {
  border-radius: 3px;
}
.img-thumbnail {
  padding: 4px;
  line-height: 1.42857143;
  background-color: #fff;
  border: 1px solid #ddd;
  border-radius: 2px;
  -webkit-transition: all 0.2s ease-in-out;
  -o-transition: all 0.2s ease-in-out;
  transition: all 0.2s ease-in-out;
  display: inline-block;
  max-width: 100%;
  height: auto;
}
.img-circle {
  border-radius: 50%;
}
hr {
  margin-top: 18px;
  margin-bottom: 18px;
  border: 0;
  border-top: 1px solid #eeeeee;
}
.sr-only {
  position: absolute;
  width: 1px;
  height: 1px;
  margin: -1px;
  padding: 0;
  overflow: hidden;
  clip: rect(0, 0, 0, 0);
  border: 0;
}
.sr-only-focusable:active,
.sr-only-focusable:focus {
  position: static;
  width: auto;
  height: auto;
  margin: 0;
  overflow: visible;
  clip: auto;
}
[role="button"] {
  cursor: pointer;
}
h1,
h2,
h3,
h4,
h5,
h6,
.h1,
.h2,
.h3,
.h4,
.h5,
.h6 {
  font-family: inherit;
  font-weight: 500;
  line-height: 1.1;
  color: inherit;
}
h1 small,
h2 small,
h3 small,
h4 small,
h5 small,
h6 small,
.h1 small,
.h2 small,
.h3 small,
.h4 small,
.h5 small,
.h6 small,
h1 .small,
h2 .small,
h3 .small,
h4 .small,
h5 .small,
h6 .small,
.h1 .small,
.h2 .small,
.h3 .small,
.h4 .small,
.h5 .small,
.h6 .small {
  font-weight: normal;
  line-height: 1;
  color: #777777;
}
h1,
.h1,
h2,
.h2,
h3,
.h3 {
  margin-top: 18px;
  margin-bottom: 9px;
}
h1 small,
.h1 small,
h2 small,
.h2 small,
h3 small,
.h3 small,
h1 .small,
.h1 .small,
h2 .small,
.h2 .small,
h3 .small,
.h3 .small {
  font-size: 65%;
}
h4,
.h4,
h5,
.h5,
h6,
.h6 {
  margin-top: 9px;
  margin-bottom: 9px;
}
h4 small,
.h4 small,
h5 small,
.h5 small,
h6 small,
.h6 small,
h4 .small,
.h4 .small,
h5 .small,
.h5 .small,
h6 .small,
.h6 .small {
  font-size: 75%;
}
h1,
.h1 {
  font-size: 33px;
}
h2,
.h2 {
  font-size: 27px;
}
h3,
.h3 {
  font-size: 23px;
}
h4,
.h4 {
  font-size: 17px;
}
h5,
.h5 {
  font-size: 13px;
}
h6,
.h6 {
  font-size: 12px;
}
p {
  margin: 0 0 9px;
}
.lead {
  margin-bottom: 18px;
  font-size: 14px;
  font-weight: 300;
  line-height: 1.4;
}
@media (min-width: 768px) {
  .lead {
    font-size: 19.5px;
  }
}
small,
.small {
  font-size: 92%;
}
mark,
.mark {
  background-color: #fcf8e3;
  padding: .2em;
}
.text-left {
  text-align: left;
}
.text-right {
  text-align: right;
}
.text-center {
  text-align: center;
}
.text-justify {
  text-align: justify;
}
.text-nowrap {
  white-space: nowrap;
}
.text-lowercase {
  text-transform: lowercase;
}
.text-uppercase {
  text-transform: uppercase;
}
.text-capitalize {
  text-transform: capitalize;
}
.text-muted {
  color: #777777;
}
.text-primary {
  color: #337ab7;
}
a.text-primary:hover,
a.text-primary:focus {
  color: #286090;
}
.text-success {
  color: #3c763d;
}
a.text-success:hover,
a.text-success:focus {
  color: #2b542c;
}
.text-info {
  color: #31708f;
}
a.text-info:hover,
a.text-info:focus {
  color: #245269;
}
.text-warning {
  color: #8a6d3b;
}
a.text-warning:hover,
a.text-warning:focus {
  color: #66512c;
}
.text-danger {
  color: #a94442;
}
a.text-danger:hover,
a.text-danger:focus {
  color: #843534;
}
.bg-primary {
  color: #fff;
  background-color: #337ab7;
}
a.bg-primary:hover,
a.bg-primary:focus {
  background-color: #286090;
}
.bg-success {
  background-color: #dff0d8;
}
a.bg-success:hover,
a.bg-success:focus {
  background-color: #c1e2b3;
}
.bg-info {
  background-color: #d9edf7;
}
a.bg-info:hover,
a.bg-info:focus {
  background-color: #afd9ee;
}
.bg-warning {
  background-color: #fcf8e3;
}
a.bg-warning:hover,
a.bg-warning:focus {
  background-color: #f7ecb5;
}
.bg-danger {
  background-color: #f2dede;
}
a.bg-danger:hover,
a.bg-danger:focus {
  background-color: #e4b9b9;
}
.page-header {
  padding-bottom: 8px;
  margin: 36px 0 18px;
  border-bottom: 1px solid #eeeeee;
}
ul,
ol {
  margin-top: 0;
  margin-bottom: 9px;
}
ul ul,
ol ul,
ul ol,
ol ol {
  margin-bottom: 0;
}
.list-unstyled {
  padding-left: 0;
  list-style: none;
}
.list-inline {
  padding-left: 0;
  list-style: none;
  margin-left: -5px;
}
.list-inline > li {
  display: inline-block;
  padding-left: 5px;
  padding-right: 5px;
}
dl {
  margin-top: 0;
  margin-bottom: 18px;
}
dt,
dd {
  line-height: 1.42857143;
}
dt {
  font-weight: bold;
}
dd {
  margin-left: 0;
}
@media (min-width: 541px) {
  .dl-horizontal dt {
    float: left;
    width: 160px;
    clear: left;
    text-align: right;
    overflow: hidden;
    text-overflow: ellipsis;
    white-space: nowrap;
  }
  .dl-horizontal dd {
    margin-left: 180px;
  }
}
abbr[title],
abbr[data-original-title] {
  cursor: help;
  border-bottom: 1px dotted #777777;
}
.initialism {
  font-size: 90%;
  text-transform: uppercase;
}
blockquote {
  padding: 9px 18px;
  margin: 0 0 18px;
  font-size: inherit;
  border-left: 5px solid #eeeeee;
}
blockquote p:last-child,
blockquote ul:last-child,
blockquote ol:last-child {
  margin-bottom: 0;
}
blockquote footer,
blockquote small,
blockquote .small {
  display: block;
  font-size: 80%;
  line-height: 1.42857143;
  color: #777777;
}
blockquote footer:before,
blockquote small:before,
blockquote .small:before {
  content: '\2014 \00A0';
}
.blockquote-reverse,
blockquote.pull-right {
  padding-right: 15px;
  padding-left: 0;
  border-right: 5px solid #eeeeee;
  border-left: 0;
  text-align: right;
}
.blockquote-reverse footer:before,
blockquote.pull-right footer:before,
.blockquote-reverse small:before,
blockquote.pull-right small:before,
.blockquote-reverse .small:before,
blockquote.pull-right .small:before {
  content: '';
}
.blockquote-reverse footer:after,
blockquote.pull-right footer:after,
.blockquote-reverse small:after,
blockquote.pull-right small:after,
.blockquote-reverse .small:after,
blockquote.pull-right .small:after {
  content: '\00A0 \2014';
}
address {
  margin-bottom: 18px;
  font-style: normal;
  line-height: 1.42857143;
}
code,
kbd,
pre,
samp {
  font-family: monospace;
}
code {
  padding: 2px 4px;
  font-size: 90%;
  color: #c7254e;
  background-color: #f9f2f4;
  border-radius: 2px;
}
kbd {
  padding: 2px 4px;
  font-size: 90%;
  color: #888;
  background-color: transparent;
  border-radius: 1px;
  box-shadow: inset 0 -1px 0 rgba(0, 0, 0, 0.25);
}
kbd kbd {
  padding: 0;
  font-size: 100%;
  font-weight: bold;
  box-shadow: none;
}
pre {
  display: block;
  padding: 8.5px;
  margin: 0 0 9px;
  font-size: 12px;
  line-height: 1.42857143;
  word-break: break-all;
  word-wrap: break-word;
  color: #333333;
  background-color: #f5f5f5;
  border: 1px solid #ccc;
  border-radius: 2px;
}
pre code {
  padding: 0;
  font-size: inherit;
  color: inherit;
  white-space: pre-wrap;
  background-color: transparent;
  border-radius: 0;
}
.pre-scrollable {
  max-height: 340px;
  overflow-y: scroll;
}
.container {
  margin-right: auto;
  margin-left: auto;
  padding-left: 0px;
  padding-right: 0px;
}
@media (min-width: 768px) {
  .container {
    width: 768px;
  }
}
@media (min-width: 992px) {
  .container {
    width: 940px;
  }
}
@media (min-width: 1200px) {
  .container {
    width: 1140px;
  }
}
.container-fluid {
  margin-right: auto;
  margin-left: auto;
  padding-left: 0px;
  padding-right: 0px;
}
.row {
  margin-left: 0px;
  margin-right: 0px;
}
.col-xs-1, .col-sm-1, .col-md-1, .col-lg-1, .col-xs-2, .col-sm-2, .col-md-2, .col-lg-2, .col-xs-3, .col-sm-3, .col-md-3, .col-lg-3, .col-xs-4, .col-sm-4, .col-md-4, .col-lg-4, .col-xs-5, .col-sm-5, .col-md-5, .col-lg-5, .col-xs-6, .col-sm-6, .col-md-6, .col-lg-6, .col-xs-7, .col-sm-7, .col-md-7, .col-lg-7, .col-xs-8, .col-sm-8, .col-md-8, .col-lg-8, .col-xs-9, .col-sm-9, .col-md-9, .col-lg-9, .col-xs-10, .col-sm-10, .col-md-10, .col-lg-10, .col-xs-11, .col-sm-11, .col-md-11, .col-lg-11, .col-xs-12, .col-sm-12, .col-md-12, .col-lg-12 {
  position: relative;
  min-height: 1px;
  padding-left: 0px;
  padding-right: 0px;
}
.col-xs-1, .col-xs-2, .col-xs-3, .col-xs-4, .col-xs-5, .col-xs-6, .col-xs-7, .col-xs-8, .col-xs-9, .col-xs-10, .col-xs-11, .col-xs-12 {
  float: left;
}
.col-xs-12 {
  width: 100%;
}
.col-xs-11 {
  width: 91.66666667%;
}
.col-xs-10 {
  width: 83.33333333%;
}
.col-xs-9 {
  width: 75%;
}
.col-xs-8 {
  width: 66.66666667%;
}
.col-xs-7 {
  width: 58.33333333%;
}
.col-xs-6 {
  width: 50%;
}
.col-xs-5 {
  width: 41.66666667%;
}
.col-xs-4 {
  width: 33.33333333%;
}
.col-xs-3 {
  width: 25%;
}
.col-xs-2 {
  width: 16.66666667%;
}
.col-xs-1 {
  width: 8.33333333%;
}
.col-xs-pull-12 {
  right: 100%;
}
.col-xs-pull-11 {
  right: 91.66666667%;
}
.col-xs-pull-10 {
  right: 83.33333333%;
}
.col-xs-pull-9 {
  right: 75%;
}
.col-xs-pull-8 {
  right: 66.66666667%;
}
.col-xs-pull-7 {
  right: 58.33333333%;
}
.col-xs-pull-6 {
  right: 50%;
}
.col-xs-pull-5 {
  right: 41.66666667%;
}
.col-xs-pull-4 {
  right: 33.33333333%;
}
.col-xs-pull-3 {
  right: 25%;
}
.col-xs-pull-2 {
  right: 16.66666667%;
}
.col-xs-pull-1 {
  right: 8.33333333%;
}
.col-xs-pull-0 {
  right: auto;
}
.col-xs-push-12 {
  left: 100%;
}
.col-xs-push-11 {
  left: 91.66666667%;
}
.col-xs-push-10 {
  left: 83.33333333%;
}
.col-xs-push-9 {
  left: 75%;
}
.col-xs-push-8 {
  left: 66.66666667%;
}
.col-xs-push-7 {
  left: 58.33333333%;
}
.col-xs-push-6 {
  left: 50%;
}
.col-xs-push-5 {
  left: 41.66666667%;
}
.col-xs-push-4 {
  left: 33.33333333%;
}
.col-xs-push-3 {
  left: 25%;
}
.col-xs-push-2 {
  left: 16.66666667%;
}
.col-xs-push-1 {
  left: 8.33333333%;
}
.col-xs-push-0 {
  left: auto;
}
.col-xs-offset-12 {
  margin-left: 100%;
}
.col-xs-offset-11 {
  margin-left: 91.66666667%;
}
.col-xs-offset-10 {
  margin-left: 83.33333333%;
}
.col-xs-offset-9 {
  margin-left: 75%;
}
.col-xs-offset-8 {
  margin-left: 66.66666667%;
}
.col-xs-offset-7 {
  margin-left: 58.33333333%;
}
.col-xs-offset-6 {
  margin-left: 50%;
}
.col-xs-offset-5 {
  margin-left: 41.66666667%;
}
.col-xs-offset-4 {
  margin-left: 33.33333333%;
}
.col-xs-offset-3 {
  margin-left: 25%;
}
.col-xs-offset-2 {
  margin-left: 16.66666667%;
}
.col-xs-offset-1 {
  margin-left: 8.33333333%;
}
.col-xs-offset-0 {
  margin-left: 0%;
}
@media (min-width: 768px) {
  .col-sm-1, .col-sm-2, .col-sm-3, .col-sm-4, .col-sm-5, .col-sm-6, .col-sm-7, .col-sm-8, .col-sm-9, .col-sm-10, .col-sm-11, .col-sm-12 {
    float: left;
  }
  .col-sm-12 {
    width: 100%;
  }
  .col-sm-11 {
    width: 91.66666667%;
  }
  .col-sm-10 {
    width: 83.33333333%;
  }
  .col-sm-9 {
    width: 75%;
  }
  .col-sm-8 {
    width: 66.66666667%;
  }
  .col-sm-7 {
    width: 58.33333333%;
  }
  .col-sm-6 {
    width: 50%;
  }
  .col-sm-5 {
    width: 41.66666667%;
  }
  .col-sm-4 {
    width: 33.33333333%;
  }
  .col-sm-3 {
    width: 25%;
  }
  .col-sm-2 {
    width: 16.66666667%;
  }
  .col-sm-1 {
    width: 8.33333333%;
  }
  .col-sm-pull-12 {
    right: 100%;
  }
  .col-sm-pull-11 {
    right: 91.66666667%;
  }
  .col-sm-pull-10 {
    right: 83.33333333%;
  }
  .col-sm-pull-9 {
    right: 75%;
  }
  .col-sm-pull-8 {
    right: 66.66666667%;
  }
  .col-sm-pull-7 {
    right: 58.33333333%;
  }
  .col-sm-pull-6 {
    right: 50%;
  }
  .col-sm-pull-5 {
    right: 41.66666667%;
  }
  .col-sm-pull-4 {
    right: 33.33333333%;
  }
  .col-sm-pull-3 {
    right: 25%;
  }
  .col-sm-pull-2 {
    right: 16.66666667%;
  }
  .col-sm-pull-1 {
    right: 8.33333333%;
  }
  .col-sm-pull-0 {
    right: auto;
  }
  .col-sm-push-12 {
    left: 100%;
  }
  .col-sm-push-11 {
    left: 91.66666667%;
  }
  .col-sm-push-10 {
    left: 83.33333333%;
  }
  .col-sm-push-9 {
    left: 75%;
  }
  .col-sm-push-8 {
    left: 66.66666667%;
  }
  .col-sm-push-7 {
    left: 58.33333333%;
  }
  .col-sm-push-6 {
    left: 50%;
  }
  .col-sm-push-5 {
    left: 41.66666667%;
  }
  .col-sm-push-4 {
    left: 33.33333333%;
  }
  .col-sm-push-3 {
    left: 25%;
  }
  .col-sm-push-2 {
    left: 16.66666667%;
  }
  .col-sm-push-1 {
    left: 8.33333333%;
  }
  .col-sm-push-0 {
    left: auto;
  }
  .col-sm-offset-12 {
    margin-left: 100%;
  }
  .col-sm-offset-11 {
    margin-left: 91.66666667%;
  }
  .col-sm-offset-10 {
    margin-left: 83.33333333%;
  }
  .col-sm-offset-9 {
    margin-left: 75%;
  }
  .col-sm-offset-8 {
    margin-left: 66.66666667%;
  }
  .col-sm-offset-7 {
    margin-left: 58.33333333%;
  }
  .col-sm-offset-6 {
    margin-left: 50%;
  }
  .col-sm-offset-5 {
    margin-left: 41.66666667%;
  }
  .col-sm-offset-4 {
    margin-left: 33.33333333%;
  }
  .col-sm-offset-3 {
    margin-left: 25%;
  }
  .col-sm-offset-2 {
    margin-left: 16.66666667%;
  }
  .col-sm-offset-1 {
    margin-left: 8.33333333%;
  }
  .col-sm-offset-0 {
    margin-left: 0%;
  }
}
@media (min-width: 992px) {
  .col-md-1, .col-md-2, .col-md-3, .col-md-4, .col-md-5, .col-md-6, .col-md-7, .col-md-8, .col-md-9, .col-md-10, .col-md-11, .col-md-12 {
    float: left;
  }
  .col-md-12 {
    width: 100%;
  }
  .col-md-11 {
    width: 91.66666667%;
  }
  .col-md-10 {
    width: 83.33333333%;
  }
  .col-md-9 {
    width: 75%;
  }
  .col-md-8 {
    width: 66.66666667%;
  }
  .col-md-7 {
    width: 58.33333333%;
  }
  .col-md-6 {
    width: 50%;
  }
  .col-md-5 {
    width: 41.66666667%;
  }
  .col-md-4 {
    width: 33.33333333%;
  }
  .col-md-3 {
    width: 25%;
  }
  .col-md-2 {
    width: 16.66666667%;
  }
  .col-md-1 {
    width: 8.33333333%;
  }
  .col-md-pull-12 {
    right: 100%;
  }
  .col-md-pull-11 {
    right: 91.66666667%;
  }
  .col-md-pull-10 {
    right: 83.33333333%;
  }
  .col-md-pull-9 {
    right: 75%;
  }
  .col-md-pull-8 {
    right: 66.66666667%;
  }
  .col-md-pull-7 {
    right: 58.33333333%;
  }
  .col-md-pull-6 {
    right: 50%;
  }
  .col-md-pull-5 {
    right: 41.66666667%;
  }
  .col-md-pull-4 {
    right: 33.33333333%;
  }
  .col-md-pull-3 {
    right: 25%;
  }
  .col-md-pull-2 {
    right: 16.66666667%;
  }
  .col-md-pull-1 {
    right: 8.33333333%;
  }
  .col-md-pull-0 {
    right: auto;
  }
  .col-md-push-12 {
    left: 100%;
  }
  .col-md-push-11 {
    left: 91.66666667%;
  }
  .col-md-push-10 {
    left: 83.33333333%;
  }
  .col-md-push-9 {
    left: 75%;
  }
  .col-md-push-8 {
    left: 66.66666667%;
  }
  .col-md-push-7 {
    left: 58.33333333%;
  }
  .col-md-push-6 {
    left: 50%;
  }
  .col-md-push-5 {
    left: 41.66666667%;
  }
  .col-md-push-4 {
    left: 33.33333333%;
  }
  .col-md-push-3 {
    left: 25%;
  }
  .col-md-push-2 {
    left: 16.66666667%;
  }
  .col-md-push-1 {
    left: 8.33333333%;
  }
  .col-md-push-0 {
    left: auto;
  }
  .col-md-offset-12 {
    margin-left: 100%;
  }
  .col-md-offset-11 {
    margin-left: 91.66666667%;
  }
  .col-md-offset-10 {
    margin-left: 83.33333333%;
  }
  .col-md-offset-9 {
    margin-left: 75%;
  }
  .col-md-offset-8 {
    margin-left: 66.66666667%;
  }
  .col-md-offset-7 {
    margin-left: 58.33333333%;
  }
  .col-md-offset-6 {
    margin-left: 50%;
  }
  .col-md-offset-5 {
    margin-left: 41.66666667%;
  }
  .col-md-offset-4 {
    margin-left: 33.33333333%;
  }
  .col-md-offset-3 {
    margin-left: 25%;
  }
  .col-md-offset-2 {
    margin-left: 16.66666667%;
  }
  .col-md-offset-1 {
    margin-left: 8.33333333%;
  }
  .col-md-offset-0 {
    margin-left: 0%;
  }
}
@media (min-width: 1200px) {
  .col-lg-1, .col-lg-2, .col-lg-3, .col-lg-4, .col-lg-5, .col-lg-6, .col-lg-7, .col-lg-8, .col-lg-9, .col-lg-10, .col-lg-11, .col-lg-12 {
    float: left;
  }
  .col-lg-12 {
    width: 100%;
  }
  .col-lg-11 {
    width: 91.66666667%;
  }
  .col-lg-10 {
    width: 83.33333333%;
  }
  .col-lg-9 {
    width: 75%;
  }
  .col-lg-8 {
    width: 66.66666667%;
  }
  .col-lg-7 {
    width: 58.33333333%;
  }
  .col-lg-6 {
    width: 50%;
  }
  .col-lg-5 {
    width: 41.66666667%;
  }
  .col-lg-4 {
    width: 33.33333333%;
  }
  .col-lg-3 {
    width: 25%;
  }
  .col-lg-2 {
    width: 16.66666667%;
  }
  .col-lg-1 {
    width: 8.33333333%;
  }
  .col-lg-pull-12 {
    right: 100%;
  }
  .col-lg-pull-11 {
    right: 91.66666667%;
  }
  .col-lg-pull-10 {
    right: 83.33333333%;
  }
  .col-lg-pull-9 {
    right: 75%;
  }
  .col-lg-pull-8 {
    right: 66.66666667%;
  }
  .col-lg-pull-7 {
    right: 58.33333333%;
  }
  .col-lg-pull-6 {
    right: 50%;
  }
  .col-lg-pull-5 {
    right: 41.66666667%;
  }
  .col-lg-pull-4 {
    right: 33.33333333%;
  }
  .col-lg-pull-3 {
    right: 25%;
  }
  .col-lg-pull-2 {
    right: 16.66666667%;
  }
  .col-lg-pull-1 {
    right: 8.33333333%;
  }
  .col-lg-pull-0 {
    right: auto;
  }
  .col-lg-push-12 {
    left: 100%;
  }
  .col-lg-push-11 {
    left: 91.66666667%;
  }
  .col-lg-push-10 {
    left: 83.33333333%;
  }
  .col-lg-push-9 {
    left: 75%;
  }
  .col-lg-push-8 {
    left: 66.66666667%;
  }
  .col-lg-push-7 {
    left: 58.33333333%;
  }
  .col-lg-push-6 {
    left: 50%;
  }
  .col-lg-push-5 {
    left: 41.66666667%;
  }
  .col-lg-push-4 {
    left: 33.33333333%;
  }
  .col-lg-push-3 {
    left: 25%;
  }
  .col-lg-push-2 {
    left: 16.66666667%;
  }
  .col-lg-push-1 {
    left: 8.33333333%;
  }
  .col-lg-push-0 {
    left: auto;
  }
  .col-lg-offset-12 {
    margin-left: 100%;
  }
  .col-lg-offset-11 {
    margin-left: 91.66666667%;
  }
  .col-lg-offset-10 {
    margin-left: 83.33333333%;
  }
  .col-lg-offset-9 {
    margin-left: 75%;
  }
  .col-lg-offset-8 {
    margin-left: 66.66666667%;
  }
  .col-lg-offset-7 {
    margin-left: 58.33333333%;
  }
  .col-lg-offset-6 {
    margin-left: 50%;
  }
  .col-lg-offset-5 {
    margin-left: 41.66666667%;
  }
  .col-lg-offset-4 {
    margin-left: 33.33333333%;
  }
  .col-lg-offset-3 {
    margin-left: 25%;
  }
  .col-lg-offset-2 {
    margin-left: 16.66666667%;
  }
  .col-lg-offset-1 {
    margin-left: 8.33333333%;
  }
  .col-lg-offset-0 {
    margin-left: 0%;
  }
}
table {
  background-color: transparent;
}
caption {
  padding-top: 8px;
  padding-bottom: 8px;
  color: #777777;
  text-align: left;
}
th {
  text-align: left;
}
.table {
  width: 100%;
  max-width: 100%;
  margin-bottom: 18px;
}
.table > thead > tr > th,
.table > tbody > tr > th,
.table > tfoot > tr > th,
.table > thead > tr > td,
.table > tbody > tr > td,
.table > tfoot > tr > td {
  padding: 8px;
  line-height: 1.42857143;
  vertical-align: top;
  border-top: 1px solid #ddd;
}
.table > thead > tr > th {
  vertical-align: bottom;
  border-bottom: 2px solid #ddd;
}
.table > caption + thead > tr:first-child > th,
.table > colgroup + thead > tr:first-child > th,
.table > thead:first-child > tr:first-child > th,
.table > caption + thead > tr:first-child > td,
.table > colgroup + thead > tr:first-child > td,
.table > thead:first-child > tr:first-child > td {
  border-top: 0;
}
.table > tbody + tbody {
  border-top: 2px solid #ddd;
}
.table .table {
  background-color: #fff;
}
.table-condensed > thead > tr > th,
.table-condensed > tbody > tr > th,
.table-condensed > tfoot > tr > th,
.table-condensed > thead > tr > td,
.table-condensed > tbody > tr > td,
.table-condensed > tfoot > tr > td {
  padding: 5px;
}
.table-bordered {
  border: 1px solid #ddd;
}
.table-bordered > thead > tr > th,
.table-bordered > tbody > tr > th,
.table-bordered > tfoot > tr > th,
.table-bordered > thead > tr > td,
.table-bordered > tbody > tr > td,
.table-bordered > tfoot > tr > td {
  border: 1px solid #ddd;
}
.table-bordered > thead > tr > th,
.table-bordered > thead > tr > td {
  border-bottom-width: 2px;
}
.table-striped > tbody > tr:nth-of-type(odd) {
  background-color: #f9f9f9;
}
.table-hover > tbody > tr:hover {
  background-color: #f5f5f5;
}
table col[class*="col-"] {
  position: static;
  float: none;
  display: table-column;
}
table td[class*="col-"],
table th[class*="col-"] {
  position: static;
  float: none;
  display: table-cell;
}
.table > thead > tr > td.active,
.table > tbody > tr > td.active,
.table > tfoot > tr > td.active,
.table > thead > tr > th.active,
.table > tbody > tr > th.active,
.table > tfoot > tr > th.active,
.table > thead > tr.active > td,
.table > tbody > tr.active > td,
.table > tfoot > tr.active > td,
.table > thead > tr.active > th,
.table > tbody > tr.active > th,
.table > tfoot > tr.active > th {
  background-color: #f5f5f5;
}
.table-hover > tbody > tr > td.active:hover,
.table-hover > tbody > tr > th.active:hover,
.table-hover > tbody > tr.active:hover > td,
.table-hover > tbody > tr:hover > .active,
.table-hover > tbody > tr.active:hover > th {
  background-color: #e8e8e8;
}
.table > thead > tr > td.success,
.table > tbody > tr > td.success,
.table > tfoot > tr > td.success,
.table > thead > tr > th.success,
.table > tbody > tr > th.success,
.table > tfoot > tr > th.success,
.table > thead > tr.success > td,
.table > tbody > tr.success > td,
.table > tfoot > tr.success > td,
.table > thead > tr.success > th,
.table > tbody > tr.success > th,
.table > tfoot > tr.success > th {
  background-color: #dff0d8;
}
.table-hover > tbody > tr > td.success:hover,
.table-hover > tbody > tr > th.success:hover,
.table-hover > tbody > tr.success:hover > td,
.table-hover > tbody > tr:hover > .success,
.table-hover > tbody > tr.success:hover > th {
  background-color: #d0e9c6;
}
.table > thead > tr > td.info,
.table > tbody > tr > td.info,
.table > tfoot > tr > td.info,
.table > thead > tr > th.info,
.table > tbody > tr > th.info,
.table > tfoot > tr > th.info,
.table > thead > tr.info > td,
.table > tbody > tr.info > td,
.table > tfoot > tr.info > td,
.table > thead > tr.info > th,
.table > tbody > tr.info > th,
.table > tfoot > tr.info > th {
  background-color: #d9edf7;
}
.table-hover > tbody > tr > td.info:hover,
.table-hover > tbody > tr > th.info:hover,
.table-hover > tbody > tr.info:hover > td,
.table-hover > tbody > tr:hover > .info,
.table-hover > tbody > tr.info:hover > th {
  background-color: #c4e3f3;
}
.table > thead > tr > td.warning,
.table > tbody > tr > td.warning,
.table > tfoot > tr > td.warning,
.table > thead > tr > th.warning,
.table > tbody > tr > th.warning,
.table > tfoot > tr > th.warning,
.table > thead > tr.warning > td,
.table > tbody > tr.warning > td,
.table > tfoot > tr.warning > td,
.table > thead > tr.warning > th,
.table > tbody > tr.warning > th,
.table > tfoot > tr.warning > th {
  background-color: #fcf8e3;
}
.table-hover > tbody > tr > td.warning:hover,
.table-hover > tbody > tr > th.warning:hover,
.table-hover > tbody > tr.warning:hover > td,
.table-hover > tbody > tr:hover > .warning,
.table-hover > tbody > tr.warning:hover > th {
  background-color: #faf2cc;
}
.table > thead > tr > td.danger,
.table > tbody > tr > td.danger,
.table > tfoot > tr > td.danger,
.table > thead > tr > th.danger,
.table > tbody > tr > th.danger,
.table > tfoot > tr > th.danger,
.table > thead > tr.danger > td,
.table > tbody > tr.danger > td,
.table > tfoot > tr.danger > td,
.table > thead > tr.danger > th,
.table > tbody > tr.danger > th,
.table > tfoot > tr.danger > th {
  background-color: #f2dede;
}
.table-hover > tbody > tr > td.danger:hover,
.table-hover > tbody > tr > th.danger:hover,
.table-hover > tbody > tr.danger:hover > td,
.table-hover > tbody > tr:hover > .danger,
.table-hover > tbody > tr.danger:hover > th {
  background-color: #ebcccc;
}
.table-responsive {
  overflow-x: auto;
  min-height: 0.01%;
}
@media screen and (max-width: 767px) {
  .table-responsive {
    width: 100%;
    margin-bottom: 13.5px;
    overflow-y: hidden;
    -ms-overflow-style: -ms-autohiding-scrollbar;
    border: 1px solid #ddd;
  }
  .table-responsive > .table {
    margin-bottom: 0;
  }
  .table-responsive > .table > thead > tr > th,
  .table-responsive > .table > tbody > tr > th,
  .table-responsive > .table > tfoot > tr > th,
  .table-responsive > .table > thead > tr > td,
  .table-responsive > .table > tbody > tr > td,
  .table-responsive > .table > tfoot > tr > td {
    white-space: nowrap;
  }
  .table-responsive > .table-bordered {
    border: 0;
  }
  .table-responsive > .table-bordered > thead > tr > th:first-child,
  .table-responsive > .table-bordered > tbody > tr > th:first-child,
  .table-responsive > .table-bordered > tfoot > tr > th:first-child,
  .table-responsive > .table-bordered > thead > tr > td:first-child,
  .table-responsive > .table-bordered > tbody > tr > td:first-child,
  .table-responsive > .table-bordered > tfoot > tr > td:first-child {
    border-left: 0;
  }
  .table-responsive > .table-bordered > thead > tr > th:last-child,
  .table-responsive > .table-bordered > tbody > tr > th:last-child,
  .table-responsive > .table-bordered > tfoot > tr > th:last-child,
  .table-responsive > .table-bordered > thead > tr > td:last-child,
  .table-responsive > .table-bordered > tbody > tr > td:last-child,
  .table-responsive > .table-bordered > tfoot > tr > td:last-child {
    border-right: 0;
  }
  .table-responsive > .table-bordered > tbody > tr:last-child > th,
  .table-responsive > .table-bordered > tfoot > tr:last-child > th,
  .table-responsive > .table-bordered > tbody > tr:last-child > td,
  .table-responsive > .table-bordered > tfoot > tr:last-child > td {
    border-bottom: 0;
  }
}
fieldset {
  padding: 0;
  margin: 0;
  border: 0;
  min-width: 0;
}
legend {
  display: block;
  width: 100%;
  padding: 0;
  margin-bottom: 18px;
  font-size: 19.5px;
  line-height: inherit;
  color: #333333;
  border: 0;
  border-bottom: 1px solid #e5e5e5;
}
label {
  display: inline-block;
  max-width: 100%;
  margin-bottom: 5px;
  font-weight: bold;
}
input[type="search"] {
  -webkit-box-sizing: border-box;
  -moz-box-sizing: border-box;
  box-sizing: border-box;
}
input[type="radio"],
input[type="checkbox"] {
  margin: 4px 0 0;
  margin-top: 1px \9;
  line-height: normal;
}
input[type="file"] {
  display: block;
}
input[type="range"] {
  display: block;
  width: 100%;
}
select[multiple],
select[size] {
  height: auto;
}
input[type="file"]:focus,
input[type="radio"]:focus,
input[type="checkbox"]:focus {
  outline: 5px auto -webkit-focus-ring-color;
  outline-offset: -2px;
}
output {
  display: block;
  padding-top: 7px;
  font-size: 13px;
  line-height: 1.42857143;
  color: #555555;
}
.form-control {
  display: block;
  width: 100%;
  height: 32px;
  padding: 6px 12px;
  font-size: 13px;
  line-height: 1.42857143;
  color: #555555;
  background-color: #fff;
  background-image: none;
  border: 1px solid #ccc;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  -webkit-transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  -o-transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
}
.form-control:focus {
  border-color: #66afe9;
  outline: 0;
  -webkit-box-shadow: inset 0 1px 1px rgba(0,0,0,.075), 0 0 8px rgba(102, 175, 233, 0.6);
  box-shadow: inset 0 1px 1px rgba(0,0,0,.075), 0 0 8px rgba(102, 175, 233, 0.6);
}
.form-control::-moz-placeholder {
  color: #999;
  opacity: 1;
}
.form-control:-ms-input-placeholder {
  color: #999;
}
.form-control::-webkit-input-placeholder {
  color: #999;
}
.form-control::-ms-expand {
  border: 0;
  background-color: transparent;
}
.form-control[disabled],
.form-control[readonly],
fieldset[disabled] .form-control {
  background-color: #eeeeee;
  opacity: 1;
}
.form-control[disabled],
fieldset[disabled] .form-control {
  cursor: not-allowed;
}
textarea.form-control {
  height: auto;
}
input[type="search"] {
  -webkit-appearance: none;
}
@media screen and (-webkit-min-device-pixel-ratio: 0) {
  input[type="date"].form-control,
  input[type="time"].form-control,
  input[type="datetime-local"].form-control,
  input[type="month"].form-control {
    line-height: 32px;
  }
  input[type="date"].input-sm,
  input[type="time"].input-sm,
  input[type="datetime-local"].input-sm,
  input[type="month"].input-sm,
  .input-group-sm input[type="date"],
  .input-group-sm input[type="time"],
  .input-group-sm input[type="datetime-local"],
  .input-group-sm input[type="month"] {
    line-height: 30px;
  }
  input[type="date"].input-lg,
  input[type="time"].input-lg,
  input[type="datetime-local"].input-lg,
  input[type="month"].input-lg,
  .input-group-lg input[type="date"],
  .input-group-lg input[type="time"],
  .input-group-lg input[type="datetime-local"],
  .input-group-lg input[type="month"] {
    line-height: 45px;
  }
}
.form-group {
  margin-bottom: 15px;
}
.radio,
.checkbox {
  position: relative;
  display: block;
  margin-top: 10px;
  margin-bottom: 10px;
}
.radio label,
.checkbox label {
  min-height: 18px;
  padding-left: 20px;
  margin-bottom: 0;
  font-weight: normal;
  cursor: pointer;
}
.radio input[type="radio"],
.radio-inline input[type="radio"],
.checkbox input[type="checkbox"],
.checkbox-inline input[type="checkbox"] {
  position: absolute;
  margin-left: -20px;
  margin-top: 4px \9;
}
.radio + .radio,
.checkbox + .checkbox {
  margin-top: -5px;
}
.radio-inline,
.checkbox-inline {
  position: relative;
  display: inline-block;
  padding-left: 20px;
  margin-bottom: 0;
  vertical-align: middle;
  font-weight: normal;
  cursor: pointer;
}
.radio-inline + .radio-inline,
.checkbox-inline + .checkbox-inline {
  margin-top: 0;
  margin-left: 10px;
}
input[type="radio"][disabled],
input[type="checkbox"][disabled],
input[type="radio"].disabled,
input[type="checkbox"].disabled,
fieldset[disabled] input[type="radio"],
fieldset[disabled] input[type="checkbox"] {
  cursor: not-allowed;
}
.radio-inline.disabled,
.checkbox-inline.disabled,
fieldset[disabled] .radio-inline,
fieldset[disabled] .checkbox-inline {
  cursor: not-allowed;
}
.radio.disabled label,
.checkbox.disabled label,
fieldset[disabled] .radio label,
fieldset[disabled] .checkbox label {
  cursor: not-allowed;
}
.form-control-static {
  padding-top: 7px;
  padding-bottom: 7px;
  margin-bottom: 0;
  min-height: 31px;
}
.form-control-static.input-lg,
.form-control-static.input-sm {
  padding-left: 0;
  padding-right: 0;
}
.input-sm {
  height: 30px;
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
select.input-sm {
  height: 30px;
  line-height: 30px;
}
textarea.input-sm,
select[multiple].input-sm {
  height: auto;
}
.form-group-sm .form-control {
  height: 30px;
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
.form-group-sm select.form-control {
  height: 30px;
  line-height: 30px;
}
.form-group-sm textarea.form-control,
.form-group-sm select[multiple].form-control {
  height: auto;
}
.form-group-sm .form-control-static {
  height: 30px;
  min-height: 30px;
  padding: 6px 10px;
  font-size: 12px;
  line-height: 1.5;
}
.input-lg {
  height: 45px;
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
  border-radius: 3px;
}
select.input-lg {
  height: 45px;
  line-height: 45px;
}
textarea.input-lg,
select[multiple].input-lg {
  height: auto;
}
.form-group-lg .form-control {
  height: 45px;
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
  border-radius: 3px;
}
.form-group-lg select.form-control {
  height: 45px;
  line-height: 45px;
}
.form-group-lg textarea.form-control,
.form-group-lg select[multiple].form-control {
  height: auto;
}
.form-group-lg .form-control-static {
  height: 45px;
  min-height: 35px;
  padding: 11px 16px;
  font-size: 17px;
  line-height: 1.3333333;
}
.has-feedback {
  position: relative;
}
.has-feedback .form-control {
  padding-right: 40px;
}
.form-control-feedback {
  position: absolute;
  top: 0;
  right: 0;
  z-index: 2;
  display: block;
  width: 32px;
  height: 32px;
  line-height: 32px;
  text-align: center;
  pointer-events: none;
}
.input-lg + .form-control-feedback,
.input-group-lg + .form-control-feedback,
.form-group-lg .form-control + .form-control-feedback {
  width: 45px;
  height: 45px;
  line-height: 45px;
}
.input-sm + .form-control-feedback,
.input-group-sm + .form-control-feedback,
.form-group-sm .form-control + .form-control-feedback {
  width: 30px;
  height: 30px;
  line-height: 30px;
}
.has-success .help-block,
.has-success .control-label,
.has-success .radio,
.has-success .checkbox,
.has-success .radio-inline,
.has-success .checkbox-inline,
.has-success.radio label,
.has-success.checkbox label,
.has-success.radio-inline label,
.has-success.checkbox-inline label {
  color: #3c763d;
}
.has-success .form-control {
  border-color: #3c763d;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
}
.has-success .form-control:focus {
  border-color: #2b542c;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #67b168;
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #67b168;
}
.has-success .input-group-addon {
  color: #3c763d;
  border-color: #3c763d;
  background-color: #dff0d8;
}
.has-success .form-control-feedback {
  color: #3c763d;
}
.has-warning .help-block,
.has-warning .control-label,
.has-warning .radio,
.has-warning .checkbox,
.has-warning .radio-inline,
.has-warning .checkbox-inline,
.has-warning.radio label,
.has-warning.checkbox label,
.has-warning.radio-inline label,
.has-warning.checkbox-inline label {
  color: #8a6d3b;
}
.has-warning .form-control {
  border-color: #8a6d3b;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
}
.has-warning .form-control:focus {
  border-color: #66512c;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #c0a16b;
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #c0a16b;
}
.has-warning .input-group-addon {
  color: #8a6d3b;
  border-color: #8a6d3b;
  background-color: #fcf8e3;
}
.has-warning .form-control-feedback {
  color: #8a6d3b;
}
.has-error .help-block,
.has-error .control-label,
.has-error .radio,
.has-error .checkbox,
.has-error .radio-inline,
.has-error .checkbox-inline,
.has-error.radio label,
.has-error.checkbox label,
.has-error.radio-inline label,
.has-error.checkbox-inline label {
  color: #a94442;
}
.has-error .form-control {
  border-color: #a94442;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
}
.has-error .form-control:focus {
  border-color: #843534;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #ce8483;
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #ce8483;
}
.has-error .input-group-addon {
  color: #a94442;
  border-color: #a94442;
  background-color: #f2dede;
}
.has-error .form-control-feedback {
  color: #a94442;
}
.has-feedback label ~ .form-control-feedback {
  top: 23px;
}
.has-feedback label.sr-only ~ .form-control-feedback {
  top: 0;
}
.help-block {
  display: block;
  margin-top: 5px;
  margin-bottom: 10px;
  color: #404040;
}
@media (min-width: 768px) {
  .form-inline .form-group {
    display: inline-block;
    margin-bottom: 0;
    vertical-align: middle;
  }
  .form-inline .form-control {
    display: inline-block;
    width: auto;
    vertical-align: middle;
  }
  .form-inline .form-control-static {
    display: inline-block;
  }
  .form-inline .input-group {
    display: inline-table;
    vertical-align: middle;
  }
  .form-inline .input-group .input-group-addon,
  .form-inline .input-group .input-group-btn,
  .form-inline .input-group .form-control {
    width: auto;
  }
  .form-inline .input-group > .form-control {
    width: 100%;
  }
  .form-inline .control-label {
    margin-bottom: 0;
    vertical-align: middle;
  }
  .form-inline .radio,
  .form-inline .checkbox {
    display: inline-block;
    margin-top: 0;
    margin-bottom: 0;
    vertical-align: middle;
  }
  .form-inline .radio label,
  .form-inline .checkbox label {
    padding-left: 0;
  }
  .form-inline .radio input[type="radio"],
  .form-inline .checkbox input[type="checkbox"] {
    position: relative;
    margin-left: 0;
  }
  .form-inline .has-feedback .form-control-feedback {
    top: 0;
  }
}
.form-horizontal .radio,
.form-horizontal .checkbox,
.form-horizontal .radio-inline,
.form-horizontal .checkbox-inline {
  margin-top: 0;
  margin-bottom: 0;
  padding-top: 7px;
}
.form-horizontal .radio,
.form-horizontal .checkbox {
  min-height: 25px;
}
.form-horizontal .form-group {
  margin-left: 0px;
  margin-right: 0px;
}
@media (min-width: 768px) {
  .form-horizontal .control-label {
    text-align: right;
    margin-bottom: 0;
    padding-top: 7px;
  }
}
.form-horizontal .has-feedback .form-control-feedback {
  right: 0px;
}
@media (min-width: 768px) {
  .form-horizontal .form-group-lg .control-label {
    padding-top: 11px;
    font-size: 17px;
  }
}
@media (min-width: 768px) {
  .form-horizontal .form-group-sm .control-label {
    padding-top: 6px;
    font-size: 12px;
  }
}
.btn {
  display: inline-block;
  margin-bottom: 0;
  font-weight: normal;
  text-align: center;
  vertical-align: middle;
  touch-action: manipulation;
  cursor: pointer;
  background-image: none;
  border: 1px solid transparent;
  white-space: nowrap;
  padding: 6px 12px;
  font-size: 13px;
  line-height: 1.42857143;
  border-radius: 2px;
  -webkit-user-select: none;
  -moz-user-select: none;
  -ms-user-select: none;
  user-select: none;
}
.btn:focus,
.btn:active:focus,
.btn.active:focus,
.btn.focus,
.btn:active.focus,
.btn.active.focus {
  outline: 5px auto -webkit-focus-ring-color;
  outline-offset: -2px;
}
.btn:hover,
.btn:focus,
.btn.focus {
  color: #333;
  text-decoration: none;
}
.btn:active,
.btn.active {
  outline: 0;
  background-image: none;
  -webkit-box-shadow: inset 0 3px 5px rgba(0, 0, 0, 0.125);
  box-shadow: inset 0 3px 5px rgba(0, 0, 0, 0.125);
}
.btn.disabled,
.btn[disabled],
fieldset[disabled] .btn {
  cursor: not-allowed;
  opacity: 0.65;
  filter: alpha(opacity=65);
  -webkit-box-shadow: none;
  box-shadow: none;
}
a.btn.disabled,
fieldset[disabled] a.btn {
  pointer-events: none;
}
.btn-default {
  color: #333;
  background-color: #fff;
  border-color: #ccc;
}
.btn-default:focus,
.btn-default.focus {
  color: #333;
  background-color: #e6e6e6;
  border-color: #8c8c8c;
}
.btn-default:hover {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
.btn-default:active,
.btn-default.active,
.open > .dropdown-toggle.btn-default {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
.btn-default:active:hover,
.btn-default.active:hover,
.open > .dropdown-toggle.btn-default:hover,
.btn-default:active:focus,
.btn-default.active:focus,
.open > .dropdown-toggle.btn-default:focus,
.btn-default:active.focus,
.btn-default.active.focus,
.open > .dropdown-toggle.btn-default.focus {
  color: #333;
  background-color: #d4d4d4;
  border-color: #8c8c8c;
}
.btn-default:active,
.btn-default.active,
.open > .dropdown-toggle.btn-default {
  background-image: none;
}
.btn-default.disabled:hover,
.btn-default[disabled]:hover,
fieldset[disabled] .btn-default:hover,
.btn-default.disabled:focus,
.btn-default[disabled]:focus,
fieldset[disabled] .btn-default:focus,
.btn-default.disabled.focus,
.btn-default[disabled].focus,
fieldset[disabled] .btn-default.focus {
  background-color: #fff;
  border-color: #ccc;
}
.btn-default .badge {
  color: #fff;
  background-color: #333;
}
.btn-primary {
  color: #fff;
  background-color: #337ab7;
  border-color: #2e6da4;
}
.btn-primary:focus,
.btn-primary.focus {
  color: #fff;
  background-color: #286090;
  border-color: #122b40;
}
.btn-primary:hover {
  color: #fff;
  background-color: #286090;
  border-color: #204d74;
}
.btn-primary:active,
.btn-primary.active,
.open > .dropdown-toggle.btn-primary {
  color: #fff;
  background-color: #286090;
  border-color: #204d74;
}
.btn-primary:active:hover,
.btn-primary.active:hover,
.open > .dropdown-toggle.btn-primary:hover,
.btn-primary:active:focus,
.btn-primary.active:focus,
.open > .dropdown-toggle.btn-primary:focus,
.btn-primary:active.focus,
.btn-primary.active.focus,
.open > .dropdown-toggle.btn-primary.focus {
  color: #fff;
  background-color: #204d74;
  border-color: #122b40;
}
.btn-primary:active,
.btn-primary.active,
.open > .dropdown-toggle.btn-primary {
  background-image: none;
}
.btn-primary.disabled:hover,
.btn-primary[disabled]:hover,
fieldset[disabled] .btn-primary:hover,
.btn-primary.disabled:focus,
.btn-primary[disabled]:focus,
fieldset[disabled] .btn-primary:focus,
.btn-primary.disabled.focus,
.btn-primary[disabled].focus,
fieldset[disabled] .btn-primary.focus {
  background-color: #337ab7;
  border-color: #2e6da4;
}
.btn-primary .badge {
  color: #337ab7;
  background-color: #fff;
}
.btn-success {
  color: #fff;
  background-color: #5cb85c;
  border-color: #4cae4c;
}
.btn-success:focus,
.btn-success.focus {
  color: #fff;
  background-color: #449d44;
  border-color: #255625;
}
.btn-success:hover {
  color: #fff;
  background-color: #449d44;
  border-color: #398439;
}
.btn-success:active,
.btn-success.active,
.open > .dropdown-toggle.btn-success {
  color: #fff;
  background-color: #449d44;
  border-color: #398439;
}
.btn-success:active:hover,
.btn-success.active:hover,
.open > .dropdown-toggle.btn-success:hover,
.btn-success:active:focus,
.btn-success.active:focus,
.open > .dropdown-toggle.btn-success:focus,
.btn-success:active.focus,
.btn-success.active.focus,
.open > .dropdown-toggle.btn-success.focus {
  color: #fff;
  background-color: #398439;
  border-color: #255625;
}
.btn-success:active,
.btn-success.active,
.open > .dropdown-toggle.btn-success {
  background-image: none;
}
.btn-success.disabled:hover,
.btn-success[disabled]:hover,
fieldset[disabled] .btn-success:hover,
.btn-success.disabled:focus,
.btn-success[disabled]:focus,
fieldset[disabled] .btn-success:focus,
.btn-success.disabled.focus,
.btn-success[disabled].focus,
fieldset[disabled] .btn-success.focus {
  background-color: #5cb85c;
  border-color: #4cae4c;
}
.btn-success .badge {
  color: #5cb85c;
  background-color: #fff;
}
.btn-info {
  color: #fff;
  background-color: #5bc0de;
  border-color: #46b8da;
}
.btn-info:focus,
.btn-info.focus {
  color: #fff;
  background-color: #31b0d5;
  border-color: #1b6d85;
}
.btn-info:hover {
  color: #fff;
  background-color: #31b0d5;
  border-color: #269abc;
}
.btn-info:active,
.btn-info.active,
.open > .dropdown-toggle.btn-info {
  color: #fff;
  background-color: #31b0d5;
  border-color: #269abc;
}
.btn-info:active:hover,
.btn-info.active:hover,
.open > .dropdown-toggle.btn-info:hover,
.btn-info:active:focus,
.btn-info.active:focus,
.open > .dropdown-toggle.btn-info:focus,
.btn-info:active.focus,
.btn-info.active.focus,
.open > .dropdown-toggle.btn-info.focus {
  color: #fff;
  background-color: #269abc;
  border-color: #1b6d85;
}
.btn-info:active,
.btn-info.active,
.open > .dropdown-toggle.btn-info {
  background-image: none;
}
.btn-info.disabled:hover,
.btn-info[disabled]:hover,
fieldset[disabled] .btn-info:hover,
.btn-info.disabled:focus,
.btn-info[disabled]:focus,
fieldset[disabled] .btn-info:focus,
.btn-info.disabled.focus,
.btn-info[disabled].focus,
fieldset[disabled] .btn-info.focus {
  background-color: #5bc0de;
  border-color: #46b8da;
}
.btn-info .badge {
  color: #5bc0de;
  background-color: #fff;
}
.btn-warning {
  color: #fff;
  background-color: #f0ad4e;
  border-color: #eea236;
}
.btn-warning:focus,
.btn-warning.focus {
  color: #fff;
  background-color: #ec971f;
  border-color: #985f0d;
}
.btn-warning:hover {
  color: #fff;
  background-color: #ec971f;
  border-color: #d58512;
}
.btn-warning:active,
.btn-warning.active,
.open > .dropdown-toggle.btn-warning {
  color: #fff;
  background-color: #ec971f;
  border-color: #d58512;
}
.btn-warning:active:hover,
.btn-warning.active:hover,
.open > .dropdown-toggle.btn-warning:hover,
.btn-warning:active:focus,
.btn-warning.active:focus,
.open > .dropdown-toggle.btn-warning:focus,
.btn-warning:active.focus,
.btn-warning.active.focus,
.open > .dropdown-toggle.btn-warning.focus {
  color: #fff;
  background-color: #d58512;
  border-color: #985f0d;
}
.btn-warning:active,
.btn-warning.active,
.open > .dropdown-toggle.btn-warning {
  background-image: none;
}
.btn-warning.disabled:hover,
.btn-warning[disabled]:hover,
fieldset[disabled] .btn-warning:hover,
.btn-warning.disabled:focus,
.btn-warning[disabled]:focus,
fieldset[disabled] .btn-warning:focus,
.btn-warning.disabled.focus,
.btn-warning[disabled].focus,
fieldset[disabled] .btn-warning.focus {
  background-color: #f0ad4e;
  border-color: #eea236;
}
.btn-warning .badge {
  color: #f0ad4e;
  background-color: #fff;
}
.btn-danger {
  color: #fff;
  background-color: #d9534f;
  border-color: #d43f3a;
}
.btn-danger:focus,
.btn-danger.focus {
  color: #fff;
  background-color: #c9302c;
  border-color: #761c19;
}
.btn-danger:hover {
  color: #fff;
  background-color: #c9302c;
  border-color: #ac2925;
}
.btn-danger:active,
.btn-danger.active,
.open > .dropdown-toggle.btn-danger {
  color: #fff;
  background-color: #c9302c;
  border-color: #ac2925;
}
.btn-danger:active:hover,
.btn-danger.active:hover,
.open > .dropdown-toggle.btn-danger:hover,
.btn-danger:active:focus,
.btn-danger.active:focus,
.open > .dropdown-toggle.btn-danger:focus,
.btn-danger:active.focus,
.btn-danger.active.focus,
.open > .dropdown-toggle.btn-danger.focus {
  color: #fff;
  background-color: #ac2925;
  border-color: #761c19;
}
.btn-danger:active,
.btn-danger.active,
.open > .dropdown-toggle.btn-danger {
  background-image: none;
}
.btn-danger.disabled:hover,
.btn-danger[disabled]:hover,
fieldset[disabled] .btn-danger:hover,
.btn-danger.disabled:focus,
.btn-danger[disabled]:focus,
fieldset[disabled] .btn-danger:focus,
.btn-danger.disabled.focus,
.btn-danger[disabled].focus,
fieldset[disabled] .btn-danger.focus {
  background-color: #d9534f;
  border-color: #d43f3a;
}
.btn-danger .badge {
  color: #d9534f;
  background-color: #fff;
}
.btn-link {
  color: #337ab7;
  font-weight: normal;
  border-radius: 0;
}
.btn-link,
.btn-link:active,
.btn-link.active,
.btn-link[disabled],
fieldset[disabled] .btn-link {
  background-color: transparent;
  -webkit-box-shadow: none;
  box-shadow: none;
}
.btn-link,
.btn-link:hover,
.btn-link:focus,
.btn-link:active {
  border-color: transparent;
}
.btn-link:hover,
.btn-link:focus {
  color: #23527c;
  text-decoration: underline;
  background-color: transparent;
}
.btn-link[disabled]:hover,
fieldset[disabled] .btn-link:hover,
.btn-link[disabled]:focus,
fieldset[disabled] .btn-link:focus {
  color: #777777;
  text-decoration: none;
}
.btn-lg,
.btn-group-lg > .btn {
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
  border-radius: 3px;
}
.btn-sm,
.btn-group-sm > .btn {
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
.btn-xs,
.btn-group-xs > .btn {
  padding: 1px 5px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
.btn-block {
  display: block;
  width: 100%;
}
.btn-block + .btn-block {
  margin-top: 5px;
}
input[type="submit"].btn-block,
input[type="reset"].btn-block,
input[type="button"].btn-block {
  width: 100%;
}
.fade {
  opacity: 0;
  -webkit-transition: opacity 0.15s linear;
  -o-transition: opacity 0.15s linear;
  transition: opacity 0.15s linear;
}
.fade.in {
  opacity: 1;
}
.collapse {
  display: none;
}
.collapse.in {
  display: block;
}
tr.collapse.in {
  display: table-row;
}
tbody.collapse.in {
  display: table-row-group;
}
.collapsing {
  position: relative;
  height: 0;
  overflow: hidden;
  -webkit-transition-property: height, visibility;
  transition-property: height, visibility;
  -webkit-transition-duration: 0.35s;
  transition-duration: 0.35s;
  -webkit-transition-timing-function: ease;
  transition-timing-function: ease;
}
.caret {
  display: inline-block;
  width: 0;
  height: 0;
  margin-left: 2px;
  vertical-align: middle;
  border-top: 4px dashed;
  border-top: 4px solid \9;
  border-right: 4px solid transparent;
  border-left: 4px solid transparent;
}
.dropup,
.dropdown {
  position: relative;
}
.dropdown-toggle:focus {
  outline: 0;
}
.dropdown-menu {
  position: absolute;
  top: 100%;
  left: 0;
  z-index: 1000;
  display: none;
  float: left;
  min-width: 160px;
  padding: 5px 0;
  margin: 2px 0 0;
  list-style: none;
  font-size: 13px;
  text-align: left;
  background-color: #fff;
  border: 1px solid #ccc;
  border: 1px solid rgba(0, 0, 0, 0.15);
  border-radius: 2px;
  -webkit-box-shadow: 0 6px 12px rgba(0, 0, 0, 0.175);
  box-shadow: 0 6px 12px rgba(0, 0, 0, 0.175);
  background-clip: padding-box;
}
.dropdown-menu.pull-right {
  right: 0;
  left: auto;
}
.dropdown-menu .divider {
  height: 1px;
  margin: 8px 0;
  overflow: hidden;
  background-color: #e5e5e5;
}
.dropdown-menu > li > a {
  display: block;
  padding: 3px 20px;
  clear: both;
  font-weight: normal;
  line-height: 1.42857143;
  color: #333333;
  white-space: nowrap;
}
.dropdown-menu > li > a:hover,
.dropdown-menu > li > a:focus {
  text-decoration: none;
  color: #262626;
  background-color: #f5f5f5;
}
.dropdown-menu > .active > a,
.dropdown-menu > .active > a:hover,
.dropdown-menu > .active > a:focus {
  color: #fff;
  text-decoration: none;
  outline: 0;
  background-color: #337ab7;
}
.dropdown-menu > .disabled > a,
.dropdown-menu > .disabled > a:hover,
.dropdown-menu > .disabled > a:focus {
  color: #777777;
}
.dropdown-menu > .disabled > a:hover,
.dropdown-menu > .disabled > a:focus {
  text-decoration: none;
  background-color: transparent;
  background-image: none;
  filter: progid:DXImageTransform.Microsoft.gradient(enabled = false);
  cursor: not-allowed;
}
.open > .dropdown-menu {
  display: block;
}
.open > a {
  outline: 0;
}
.dropdown-menu-right {
  left: auto;
  right: 0;
}
.dropdown-menu-left {
  left: 0;
  right: auto;
}
.dropdown-header {
  display: block;
  padding: 3px 20px;
  font-size: 12px;
  line-height: 1.42857143;
  color: #777777;
  white-space: nowrap;
}
.dropdown-backdrop {
  position: fixed;
  left: 0;
  right: 0;
  bottom: 0;
  top: 0;
  z-index: 990;
}
.pull-right > .dropdown-menu {
  right: 0;
  left: auto;
}
.dropup .caret,
.navbar-fixed-bottom .dropdown .caret {
  border-top: 0;
  border-bottom: 4px dashed;
  border-bottom: 4px solid \9;
  content: "";
}
.dropup .dropdown-menu,
.navbar-fixed-bottom .dropdown .dropdown-menu {
  top: auto;
  bottom: 100%;
  margin-bottom: 2px;
}
@media (min-width: 541px) {
  .navbar-right .dropdown-menu {
    left: auto;
    right: 0;
  }
  .navbar-right .dropdown-menu-left {
    left: 0;
    right: auto;
  }
}
.btn-group,
.btn-group-vertical {
  position: relative;
  display: inline-block;
  vertical-align: middle;
}
.btn-group > .btn,
.btn-group-vertical > .btn {
  position: relative;
  float: left;
}
.btn-group > .btn:hover,
.btn-group-vertical > .btn:hover,
.btn-group > .btn:focus,
.btn-group-vertical > .btn:focus,
.btn-group > .btn:active,
.btn-group-vertical > .btn:active,
.btn-group > .btn.active,
.btn-group-vertical > .btn.active {
  z-index: 2;
}
.btn-group .btn + .btn,
.btn-group .btn + .btn-group,
.btn-group .btn-group + .btn,
.btn-group .btn-group + .btn-group {
  margin-left: -1px;
}
.btn-toolbar {
  margin-left: -5px;
}
.btn-toolbar .btn,
.btn-toolbar .btn-group,
.btn-toolbar .input-group {
  float: left;
}
.btn-toolbar > .btn,
.btn-toolbar > .btn-group,
.btn-toolbar > .input-group {
  margin-left: 5px;
}
.btn-group > .btn:not(:first-child):not(:last-child):not(.dropdown-toggle) {
  border-radius: 0;
}
.btn-group > .btn:first-child {
  margin-left: 0;
}
.btn-group > .btn:first-child:not(:last-child):not(.dropdown-toggle) {
  border-bottom-right-radius: 0;
  border-top-right-radius: 0;
}
.btn-group > .btn:last-child:not(:first-child),
.btn-group > .dropdown-toggle:not(:first-child) {
  border-bottom-left-radius: 0;
  border-top-left-radius: 0;
}
.btn-group > .btn-group {
  float: left;
}
.btn-group > .btn-group:not(:first-child):not(:last-child) > .btn {
  border-radius: 0;
}
.btn-group > .btn-group:first-child:not(:last-child) > .btn:last-child,
.btn-group > .btn-group:first-child:not(:last-child) > .dropdown-toggle {
  border-bottom-right-radius: 0;
  border-top-right-radius: 0;
}
.btn-group > .btn-group:last-child:not(:first-child) > .btn:first-child {
  border-bottom-left-radius: 0;
  border-top-left-radius: 0;
}
.btn-group .dropdown-toggle:active,
.btn-group.open .dropdown-toggle {
  outline: 0;
}
.btn-group > .btn + .dropdown-toggle {
  padding-left: 8px;
  padding-right: 8px;
}
.btn-group > .btn-lg + .dropdown-toggle {
  padding-left: 12px;
  padding-right: 12px;
}
.btn-group.open .dropdown-toggle {
  -webkit-box-shadow: inset 0 3px 5px rgba(0, 0, 0, 0.125);
  box-shadow: inset 0 3px 5px rgba(0, 0, 0, 0.125);
}
.btn-group.open .dropdown-toggle.btn-link {
  -webkit-box-shadow: none;
  box-shadow: none;
}
.btn .caret {
  margin-left: 0;
}
.btn-lg .caret {
  border-width: 5px 5px 0;
  border-bottom-width: 0;
}
.dropup .btn-lg .caret {
  border-width: 0 5px 5px;
}
.btn-group-vertical > .btn,
.btn-group-vertical > .btn-group,
.btn-group-vertical > .btn-group > .btn {
  display: block;
  float: none;
  width: 100%;
  max-width: 100%;
}
.btn-group-vertical > .btn-group > .btn {
  float: none;
}
.btn-group-vertical > .btn + .btn,
.btn-group-vertical > .btn + .btn-group,
.btn-group-vertical > .btn-group + .btn,
.btn-group-vertical > .btn-group + .btn-group {
  margin-top: -1px;
  margin-left: 0;
}
.btn-group-vertical > .btn:not(:first-child):not(:last-child) {
  border-radius: 0;
}
.btn-group-vertical > .btn:first-child:not(:last-child) {
  border-top-right-radius: 2px;
  border-top-left-radius: 2px;
  border-bottom-right-radius: 0;
  border-bottom-left-radius: 0;
}
.btn-group-vertical > .btn:last-child:not(:first-child) {
  border-top-right-radius: 0;
  border-top-left-radius: 0;
  border-bottom-right-radius: 2px;
  border-bottom-left-radius: 2px;
}
.btn-group-vertical > .btn-group:not(:first-child):not(:last-child) > .btn {
  border-radius: 0;
}
.btn-group-vertical > .btn-group:first-child:not(:last-child) > .btn:last-child,
.btn-group-vertical > .btn-group:first-child:not(:last-child) > .dropdown-toggle {
  border-bottom-right-radius: 0;
  border-bottom-left-radius: 0;
}
.btn-group-vertical > .btn-group:last-child:not(:first-child) > .btn:first-child {
  border-top-right-radius: 0;
  border-top-left-radius: 0;
}
.btn-group-justified {
  display: table;
  width: 100%;
  table-layout: fixed;
  border-collapse: separate;
}
.btn-group-justified > .btn,
.btn-group-justified > .btn-group {
  float: none;
  display: table-cell;
  width: 1%;
}
.btn-group-justified > .btn-group .btn {
  width: 100%;
}
.btn-group-justified > .btn-group .dropdown-menu {
  left: auto;
}
[data-toggle="buttons"] > .btn input[type="radio"],
[data-toggle="buttons"] > .btn-group > .btn input[type="radio"],
[data-toggle="buttons"] > .btn input[type="checkbox"],
[data-toggle="buttons"] > .btn-group > .btn input[type="checkbox"] {
  position: absolute;
  clip: rect(0, 0, 0, 0);
  pointer-events: none;
}
.input-group {
  position: relative;
  display: table;
  border-collapse: separate;
}
.input-group[class*="col-"] {
  float: none;
  padding-left: 0;
  padding-right: 0;
}
.input-group .form-control {
  position: relative;
  z-index: 2;
  float: left;
  width: 100%;
  margin-bottom: 0;
}
.input-group .form-control:focus {
  z-index: 3;
}
.input-group-lg > .form-control,
.input-group-lg > .input-group-addon,
.input-group-lg > .input-group-btn > .btn {
  height: 45px;
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
  border-radius: 3px;
}
select.input-group-lg > .form-control,
select.input-group-lg > .input-group-addon,
select.input-group-lg > .input-group-btn > .btn {
  height: 45px;
  line-height: 45px;
}
textarea.input-group-lg > .form-control,
textarea.input-group-lg > .input-group-addon,
textarea.input-group-lg > .input-group-btn > .btn,
select[multiple].input-group-lg > .form-control,
select[multiple].input-group-lg > .input-group-addon,
select[multiple].input-group-lg > .input-group-btn > .btn {
  height: auto;
}
.input-group-sm > .form-control,
.input-group-sm > .input-group-addon,
.input-group-sm > .input-group-btn > .btn {
  height: 30px;
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
select.input-group-sm > .form-control,
select.input-group-sm > .input-group-addon,
select.input-group-sm > .input-group-btn > .btn {
  height: 30px;
  line-height: 30px;
}
textarea.input-group-sm > .form-control,
textarea.input-group-sm > .input-group-addon,
textarea.input-group-sm > .input-group-btn > .btn,
select[multiple].input-group-sm > .form-control,
select[multiple].input-group-sm > .input-group-addon,
select[multiple].input-group-sm > .input-group-btn > .btn {
  height: auto;
}
.input-group-addon,
.input-group-btn,
.input-group .form-control {
  display: table-cell;
}
.input-group-addon:not(:first-child):not(:last-child),
.input-group-btn:not(:first-child):not(:last-child),
.input-group .form-control:not(:first-child):not(:last-child) {
  border-radius: 0;
}
.input-group-addon,
.input-group-btn {
  width: 1%;
  white-space: nowrap;
  vertical-align: middle;
}
.input-group-addon {
  padding: 6px 12px;
  font-size: 13px;
  font-weight: normal;
  line-height: 1;
  color: #555555;
  text-align: center;
  background-color: #eeeeee;
  border: 1px solid #ccc;
  border-radius: 2px;
}
.input-group-addon.input-sm {
  padding: 5px 10px;
  font-size: 12px;
  border-radius: 1px;
}
.input-group-addon.input-lg {
  padding: 10px 16px;
  font-size: 17px;
  border-radius: 3px;
}
.input-group-addon input[type="radio"],
.input-group-addon input[type="checkbox"] {
  margin-top: 0;
}
.input-group .form-control:first-child,
.input-group-addon:first-child,
.input-group-btn:first-child > .btn,
.input-group-btn:first-child > .btn-group > .btn,
.input-group-btn:first-child > .dropdown-toggle,
.input-group-btn:last-child > .btn:not(:last-child):not(.dropdown-toggle),
.input-group-btn:last-child > .btn-group:not(:last-child) > .btn {
  border-bottom-right-radius: 0;
  border-top-right-radius: 0;
}
.input-group-addon:first-child {
  border-right: 0;
}
.input-group .form-control:last-child,
.input-group-addon:last-child,
.input-group-btn:last-child > .btn,
.input-group-btn:last-child > .btn-group > .btn,
.input-group-btn:last-child > .dropdown-toggle,
.input-group-btn:first-child > .btn:not(:first-child),
.input-group-btn:first-child > .btn-group:not(:first-child) > .btn {
  border-bottom-left-radius: 0;
  border-top-left-radius: 0;
}
.input-group-addon:last-child {
  border-left: 0;
}
.input-group-btn {
  position: relative;
  font-size: 0;
  white-space: nowrap;
}
.input-group-btn > .btn {
  position: relative;
}
.input-group-btn > .btn + .btn {
  margin-left: -1px;
}
.input-group-btn > .btn:hover,
.input-group-btn > .btn:focus,
.input-group-btn > .btn:active {
  z-index: 2;
}
.input-group-btn:first-child > .btn,
.input-group-btn:first-child > .btn-group {
  margin-right: -1px;
}
.input-group-btn:last-child > .btn,
.input-group-btn:last-child > .btn-group {
  z-index: 2;
  margin-left: -1px;
}
.nav {
  margin-bottom: 0;
  padding-left: 0;
  list-style: none;
}
.nav > li {
  position: relative;
  display: block;
}
.nav > li > a {
  position: relative;
  display: block;
  padding: 10px 15px;
}
.nav > li > a:hover,
.nav > li > a:focus {
  text-decoration: none;
  background-color: #eeeeee;
}
.nav > li.disabled > a {
  color: #777777;
}
.nav > li.disabled > a:hover,
.nav > li.disabled > a:focus {
  color: #777777;
  text-decoration: none;
  background-color: transparent;
  cursor: not-allowed;
}
.nav .open > a,
.nav .open > a:hover,
.nav .open > a:focus {
  background-color: #eeeeee;
  border-color: #337ab7;
}
.nav .nav-divider {
  height: 1px;
  margin: 8px 0;
  overflow: hidden;
  background-color: #e5e5e5;
}
.nav > li > a > img {
  max-width: none;
}
.nav-tabs {
  border-bottom: 1px solid #ddd;
}
.nav-tabs > li {
  float: left;
  margin-bottom: -1px;
}
.nav-tabs > li > a {
  margin-right: 2px;
  line-height: 1.42857143;
  border: 1px solid transparent;
  border-radius: 2px 2px 0 0;
}
.nav-tabs > li > a:hover {
  border-color: #eeeeee #eeeeee #ddd;
}
.nav-tabs > li.active > a,
.nav-tabs > li.active > a:hover,
.nav-tabs > li.active > a:focus {
  color: #555555;
  background-color: #fff;
  border: 1px solid #ddd;
  border-bottom-color: transparent;
  cursor: default;
}
.nav-tabs.nav-justified {
  width: 100%;
  border-bottom: 0;
}
.nav-tabs.nav-justified > li {
  float: none;
}
.nav-tabs.nav-justified > li > a {
  text-align: center;
  margin-bottom: 5px;
}
.nav-tabs.nav-justified > .dropdown .dropdown-menu {
  top: auto;
  left: auto;
}
@media (min-width: 768px) {
  .nav-tabs.nav-justified > li {
    display: table-cell;
    width: 1%;
  }
  .nav-tabs.nav-justified > li > a {
    margin-bottom: 0;
  }
}
.nav-tabs.nav-justified > li > a {
  margin-right: 0;
  border-radius: 2px;
}
.nav-tabs.nav-justified > .active > a,
.nav-tabs.nav-justified > .active > a:hover,
.nav-tabs.nav-justified > .active > a:focus {
  border: 1px solid #ddd;
}
@media (min-width: 768px) {
  .nav-tabs.nav-justified > li > a {
    border-bottom: 1px solid #ddd;
    border-radius: 2px 2px 0 0;
  }
  .nav-tabs.nav-justified > .active > a,
  .nav-tabs.nav-justified > .active > a:hover,
  .nav-tabs.nav-justified > .active > a:focus {
    border-bottom-color: #fff;
  }
}
.nav-pills > li {
  float: left;
}
.nav-pills > li > a {
  border-radius: 2px;
}
.nav-pills > li + li {
  margin-left: 2px;
}
.nav-pills > li.active > a,
.nav-pills > li.active > a:hover,
.nav-pills > li.active > a:focus {
  color: #fff;
  background-color: #337ab7;
}
.nav-stacked > li {
  float: none;
}
.nav-stacked > li + li {
  margin-top: 2px;
  margin-left: 0;
}
.nav-justified {
  width: 100%;
}
.nav-justified > li {
  float: none;
}
.nav-justified > li > a {
  text-align: center;
  margin-bottom: 5px;
}
.nav-justified > .dropdown .dropdown-menu {
  top: auto;
  left: auto;
}
@media (min-width: 768px) {
  .nav-justified > li {
    display: table-cell;
    width: 1%;
  }
  .nav-justified > li > a {
    margin-bottom: 0;
  }
}
.nav-tabs-justified {
  border-bottom: 0;
}
.nav-tabs-justified > li > a {
  margin-right: 0;
  border-radius: 2px;
}
.nav-tabs-justified > .active > a,
.nav-tabs-justified > .active > a:hover,
.nav-tabs-justified > .active > a:focus {
  border: 1px solid #ddd;
}
@media (min-width: 768px) {
  .nav-tabs-justified > li > a {
    border-bottom: 1px solid #ddd;
    border-radius: 2px 2px 0 0;
  }
  .nav-tabs-justified > .active > a,
  .nav-tabs-justified > .active > a:hover,
  .nav-tabs-justified > .active > a:focus {
    border-bottom-color: #fff;
  }
}
.tab-content > .tab-pane {
  display: none;
}
.tab-content > .active {
  display: block;
}
.nav-tabs .dropdown-menu {
  margin-top: -1px;
  border-top-right-radius: 0;
  border-top-left-radius: 0;
}
.navbar {
  position: relative;
  min-height: 30px;
  margin-bottom: 18px;
  border: 1px solid transparent;
}
@media (min-width: 541px) {
  .navbar {
    border-radius: 2px;
  }
}
@media (min-width: 541px) {
  .navbar-header {
    float: left;
  }
}
.navbar-collapse {
  overflow-x: visible;
  padding-right: 0px;
  padding-left: 0px;
  border-top: 1px solid transparent;
  box-shadow: inset 0 1px 0 rgba(255, 255, 255, 0.1);
  -webkit-overflow-scrolling: touch;
}
.navbar-collapse.in {
  overflow-y: auto;
}
@media (min-width: 541px) {
  .navbar-collapse {
    width: auto;
    border-top: 0;
    box-shadow: none;
  }
  .navbar-collapse.collapse {
    display: block !important;
    height: auto !important;
    padding-bottom: 0;
    overflow: visible !important;
  }
  .navbar-collapse.in {
    overflow-y: visible;
  }
  .navbar-fixed-top .navbar-collapse,
  .navbar-static-top .navbar-collapse,
  .navbar-fixed-bottom .navbar-collapse {
    padding-left: 0;
    padding-right: 0;
  }
}
.navbar-fixed-top .navbar-collapse,
.navbar-fixed-bottom .navbar-collapse {
  max-height: 340px;
}
@media (max-device-width: 540px) and (orientation: landscape) {
  .navbar-fixed-top .navbar-collapse,
  .navbar-fixed-bottom .navbar-collapse {
    max-height: 200px;
  }
}
.container > .navbar-header,
.container-fluid > .navbar-header,
.container > .navbar-collapse,
.container-fluid > .navbar-collapse {
  margin-right: 0px;
  margin-left: 0px;
}
@media (min-width: 541px) {
  .container > .navbar-header,
  .container-fluid > .navbar-header,
  .container > .navbar-collapse,
  .container-fluid > .navbar-collapse {
    margin-right: 0;
    margin-left: 0;
  }
}
.navbar-static-top {
  z-index: 1000;
  border-width: 0 0 1px;
}
@media (min-width: 541px) {
  .navbar-static-top {
    border-radius: 0;
  }
}
.navbar-fixed-top,
.navbar-fixed-bottom {
  position: fixed;
  right: 0;
  left: 0;
  z-index: 1030;
}
@media (min-width: 541px) {
  .navbar-fixed-top,
  .navbar-fixed-bottom {
    border-radius: 0;
  }
}
.navbar-fixed-top {
  top: 0;
  border-width: 0 0 1px;
}
.navbar-fixed-bottom {
  bottom: 0;
  margin-bottom: 0;
  border-width: 1px 0 0;
}
.navbar-brand {
  float: left;
  padding: 6px 0px;
  font-size: 17px;
  line-height: 18px;
  height: 30px;
}
.navbar-brand:hover,
.navbar-brand:focus {
  text-decoration: none;
}
.navbar-brand > img {
  display: block;
}
@media (min-width: 541px) {
  .navbar > .container .navbar-brand,
  .navbar > .container-fluid .navbar-brand {
    margin-left: 0px;
  }
}
.navbar-toggle {
  position: relative;
  float: right;
  margin-right: 0px;
  padding: 9px 10px;
  margin-top: -2px;
  margin-bottom: -2px;
  background-color: transparent;
  background-image: none;
  border: 1px solid transparent;
  border-radius: 2px;
}
.navbar-toggle:focus {
  outline: 0;
}
.navbar-toggle .icon-bar {
  display: block;
  width: 22px;
  height: 2px;
  border-radius: 1px;
}
.navbar-toggle .icon-bar + .icon-bar {
  margin-top: 4px;
}
@media (min-width: 541px) {
  .navbar-toggle {
    display: none;
  }
}
.navbar-nav {
  margin: 3px 0px;
}
.navbar-nav > li > a {
  padding-top: 10px;
  padding-bottom: 10px;
  line-height: 18px;
}
@media (max-width: 540px) {
  .navbar-nav .open .dropdown-menu {
    position: static;
    float: none;
    width: auto;
    margin-top: 0;
    background-color: transparent;
    border: 0;
    box-shadow: none;
  }
  .navbar-nav .open .dropdown-menu > li > a,
  .navbar-nav .open .dropdown-menu .dropdown-header {
    padding: 5px 15px 5px 25px;
  }
  .navbar-nav .open .dropdown-menu > li > a {
    line-height: 18px;
  }
  .navbar-nav .open .dropdown-menu > li > a:hover,
  .navbar-nav .open .dropdown-menu > li > a:focus {
    background-image: none;
  }
}
@media (min-width: 541px) {
  .navbar-nav {
    float: left;
    margin: 0;
  }
  .navbar-nav > li {
    float: left;
  }
  .navbar-nav > li > a {
    padding-top: 6px;
    padding-bottom: 6px;
  }
}
.navbar-form {
  margin-left: 0px;
  margin-right: 0px;
  padding: 10px 0px;
  border-top: 1px solid transparent;
  border-bottom: 1px solid transparent;
  -webkit-box-shadow: inset 0 1px 0 rgba(255, 255, 255, 0.1), 0 1px 0 rgba(255, 255, 255, 0.1);
  box-shadow: inset 0 1px 0 rgba(255, 255, 255, 0.1), 0 1px 0 rgba(255, 255, 255, 0.1);
  margin-top: -1px;
  margin-bottom: -1px;
}
@media (min-width: 768px) {
  .navbar-form .form-group {
    display: inline-block;
    margin-bottom: 0;
    vertical-align: middle;
  }
  .navbar-form .form-control {
    display: inline-block;
    width: auto;
    vertical-align: middle;
  }
  .navbar-form .form-control-static {
    display: inline-block;
  }
  .navbar-form .input-group {
    display: inline-table;
    vertical-align: middle;
  }
  .navbar-form .input-group .input-group-addon,
  .navbar-form .input-group .input-group-btn,
  .navbar-form .input-group .form-control {
    width: auto;
  }
  .navbar-form .input-group > .form-control {
    width: 100%;
  }
  .navbar-form .control-label {
    margin-bottom: 0;
    vertical-align: middle;
  }
  .navbar-form .radio,
  .navbar-form .checkbox {
    display: inline-block;
    margin-top: 0;
    margin-bottom: 0;
    vertical-align: middle;
  }
  .navbar-form .radio label,
  .navbar-form .checkbox label {
    padding-left: 0;
  }
  .navbar-form .radio input[type="radio"],
  .navbar-form .checkbox input[type="checkbox"] {
    position: relative;
    margin-left: 0;
  }
  .navbar-form .has-feedback .form-control-feedback {
    top: 0;
  }
}
@media (max-width: 540px) {
  .navbar-form .form-group {
    margin-bottom: 5px;
  }
  .navbar-form .form-group:last-child {
    margin-bottom: 0;
  }
}
@media (min-width: 541px) {
  .navbar-form {
    width: auto;
    border: 0;
    margin-left: 0;
    margin-right: 0;
    padding-top: 0;
    padding-bottom: 0;
    -webkit-box-shadow: none;
    box-shadow: none;
  }
}
.navbar-nav > li > .dropdown-menu {
  margin-top: 0;
  border-top-right-radius: 0;
  border-top-left-radius: 0;
}
.navbar-fixed-bottom .navbar-nav > li > .dropdown-menu {
  margin-bottom: 0;
  border-top-right-radius: 2px;
  border-top-left-radius: 2px;
  border-bottom-right-radius: 0;
  border-bottom-left-radius: 0;
}
.navbar-btn {
  margin-top: -1px;
  margin-bottom: -1px;
}
.navbar-btn.btn-sm {
  margin-top: 0px;
  margin-bottom: 0px;
}
.navbar-btn.btn-xs {
  margin-top: 4px;
  margin-bottom: 4px;
}
.navbar-text {
  margin-top: 6px;
  margin-bottom: 6px;
}
@media (min-width: 541px) {
  .navbar-text {
    float: left;
    margin-left: 0px;
    margin-right: 0px;
  }
}
@media (min-width: 541px) {
  .navbar-left {
    float: left !important;
    float: left;
  }
  .navbar-right {
    float: right !important;
    float: right;
    margin-right: 0px;
  }
  .navbar-right ~ .navbar-right {
    margin-right: 0;
  }
}
.navbar-default {
  background-color: #f8f8f8;
  border-color: #e7e7e7;
}
.navbar-default .navbar-brand {
  color: #777;
}
.navbar-default .navbar-brand:hover,
.navbar-default .navbar-brand:focus {
  color: #5e5e5e;
  background-color: transparent;
}
.navbar-default .navbar-text {
  color: #777;
}
.navbar-default .navbar-nav > li > a {
  color: #777;
}
.navbar-default .navbar-nav > li > a:hover,
.navbar-default .navbar-nav > li > a:focus {
  color: #333;
  background-color: transparent;
}
.navbar-default .navbar-nav > .active > a,
.navbar-default .navbar-nav > .active > a:hover,
.navbar-default .navbar-nav > .active > a:focus {
  color: #555;
  background-color: #e7e7e7;
}
.navbar-default .navbar-nav > .disabled > a,
.navbar-default .navbar-nav > .disabled > a:hover,
.navbar-default .navbar-nav > .disabled > a:focus {
  color: #ccc;
  background-color: transparent;
}
.navbar-default .navbar-toggle {
  border-color: #ddd;
}
.navbar-default .navbar-toggle:hover,
.navbar-default .navbar-toggle:focus {
  background-color: #ddd;
}
.navbar-default .navbar-toggle .icon-bar {
  background-color: #888;
}
.navbar-default .navbar-collapse,
.navbar-default .navbar-form {
  border-color: #e7e7e7;
}
.navbar-default .navbar-nav > .open > a,
.navbar-default .navbar-nav > .open > a:hover,
.navbar-default .navbar-nav > .open > a:focus {
  background-color: #e7e7e7;
  color: #555;
}
@media (max-width: 540px) {
  .navbar-default .navbar-nav .open .dropdown-menu > li > a {
    color: #777;
  }
  .navbar-default .navbar-nav .open .dropdown-menu > li > a:hover,
  .navbar-default .navbar-nav .open .dropdown-menu > li > a:focus {
    color: #333;
    background-color: transparent;
  }
  .navbar-default .navbar-nav .open .dropdown-menu > .active > a,
  .navbar-default .navbar-nav .open .dropdown-menu > .active > a:hover,
  .navbar-default .navbar-nav .open .dropdown-menu > .active > a:focus {
    color: #555;
    background-color: #e7e7e7;
  }
  .navbar-default .navbar-nav .open .dropdown-menu > .disabled > a,
  .navbar-default .navbar-nav .open .dropdown-menu > .disabled > a:hover,
  .navbar-default .navbar-nav .open .dropdown-menu > .disabled > a:focus {
    color: #ccc;
    background-color: transparent;
  }
}
.navbar-default .navbar-link {
  color: #777;
}
.navbar-default .navbar-link:hover {
  color: #333;
}
.navbar-default .btn-link {
  color: #777;
}
.navbar-default .btn-link:hover,
.navbar-default .btn-link:focus {
  color: #333;
}
.navbar-default .btn-link[disabled]:hover,
fieldset[disabled] .navbar-default .btn-link:hover,
.navbar-default .btn-link[disabled]:focus,
fieldset[disabled] .navbar-default .btn-link:focus {
  color: #ccc;
}
.navbar-inverse {
  background-color: #222;
  border-color: #080808;
}
.navbar-inverse .navbar-brand {
  color: #9d9d9d;
}
.navbar-inverse .navbar-brand:hover,
.navbar-inverse .navbar-brand:focus {
  color: #fff;
  background-color: transparent;
}
.navbar-inverse .navbar-text {
  color: #9d9d9d;
}
.navbar-inverse .navbar-nav > li > a {
  color: #9d9d9d;
}
.navbar-inverse .navbar-nav > li > a:hover,
.navbar-inverse .navbar-nav > li > a:focus {
  color: #fff;
  background-color: transparent;
}
.navbar-inverse .navbar-nav > .active > a,
.navbar-inverse .navbar-nav > .active > a:hover,
.navbar-inverse .navbar-nav > .active > a:focus {
  color: #fff;
  background-color: #080808;
}
.navbar-inverse .navbar-nav > .disabled > a,
.navbar-inverse .navbar-nav > .disabled > a:hover,
.navbar-inverse .navbar-nav > .disabled > a:focus {
  color: #444;
  background-color: transparent;
}
.navbar-inverse .navbar-toggle {
  border-color: #333;
}
.navbar-inverse .navbar-toggle:hover,
.navbar-inverse .navbar-toggle:focus {
  background-color: #333;
}
.navbar-inverse .navbar-toggle .icon-bar {
  background-color: #fff;
}
.navbar-inverse .navbar-collapse,
.navbar-inverse .navbar-form {
  border-color: #101010;
}
.navbar-inverse .navbar-nav > .open > a,
.navbar-inverse .navbar-nav > .open > a:hover,
.navbar-inverse .navbar-nav > .open > a:focus {
  background-color: #080808;
  color: #fff;
}
@media (max-width: 540px) {
  .navbar-inverse .navbar-nav .open .dropdown-menu > .dropdown-header {
    border-color: #080808;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu .divider {
    background-color: #080808;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu > li > a {
    color: #9d9d9d;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu > li > a:hover,
  .navbar-inverse .navbar-nav .open .dropdown-menu > li > a:focus {
    color: #fff;
    background-color: transparent;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu > .active > a,
  .navbar-inverse .navbar-nav .open .dropdown-menu > .active > a:hover,
  .navbar-inverse .navbar-nav .open .dropdown-menu > .active > a:focus {
    color: #fff;
    background-color: #080808;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu > .disabled > a,
  .navbar-inverse .navbar-nav .open .dropdown-menu > .disabled > a:hover,
  .navbar-inverse .navbar-nav .open .dropdown-menu > .disabled > a:focus {
    color: #444;
    background-color: transparent;
  }
}
.navbar-inverse .navbar-link {
  color: #9d9d9d;
}
.navbar-inverse .navbar-link:hover {
  color: #fff;
}
.navbar-inverse .btn-link {
  color: #9d9d9d;
}
.navbar-inverse .btn-link:hover,
.navbar-inverse .btn-link:focus {
  color: #fff;
}
.navbar-inverse .btn-link[disabled]:hover,
fieldset[disabled] .navbar-inverse .btn-link:hover,
.navbar-inverse .btn-link[disabled]:focus,
fieldset[disabled] .navbar-inverse .btn-link:focus {
  color: #444;
}
.breadcrumb {
  padding: 8px 15px;
  margin-bottom: 18px;
  list-style: none;
  background-color: #f5f5f5;
  border-radius: 2px;
}
.breadcrumb > li {
  display: inline-block;
}
.breadcrumb > li + li:before {
  content: "/\00a0";
  padding: 0 5px;
  color: #5e5e5e;
}
.breadcrumb > .active {
  color: #777777;
}
.pagination {
  display: inline-block;
  padding-left: 0;
  margin: 18px 0;
  border-radius: 2px;
}
.pagination > li {
  display: inline;
}
.pagination > li > a,
.pagination > li > span {
  position: relative;
  float: left;
  padding: 6px 12px;
  line-height: 1.42857143;
  text-decoration: none;
  color: #337ab7;
  background-color: #fff;
  border: 1px solid #ddd;
  margin-left: -1px;
}
.pagination > li:first-child > a,
.pagination > li:first-child > span {
  margin-left: 0;
  border-bottom-left-radius: 2px;
  border-top-left-radius: 2px;
}
.pagination > li:last-child > a,
.pagination > li:last-child > span {
  border-bottom-right-radius: 2px;
  border-top-right-radius: 2px;
}
.pagination > li > a:hover,
.pagination > li > span:hover,
.pagination > li > a:focus,
.pagination > li > span:focus {
  z-index: 2;
  color: #23527c;
  background-color: #eeeeee;
  border-color: #ddd;
}
.pagination > .active > a,
.pagination > .active > span,
.pagination > .active > a:hover,
.pagination > .active > span:hover,
.pagination > .active > a:focus,
.pagination > .active > span:focus {
  z-index: 3;
  color: #fff;
  background-color: #337ab7;
  border-color: #337ab7;
  cursor: default;
}
.pagination > .disabled > span,
.pagination > .disabled > span:hover,
.pagination > .disabled > span:focus,
.pagination > .disabled > a,
.pagination > .disabled > a:hover,
.pagination > .disabled > a:focus {
  color: #777777;
  background-color: #fff;
  border-color: #ddd;
  cursor: not-allowed;
}
.pagination-lg > li > a,
.pagination-lg > li > span {
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
}
.pagination-lg > li:first-child > a,
.pagination-lg > li:first-child > span {
  border-bottom-left-radius: 3px;
  border-top-left-radius: 3px;
}
.pagination-lg > li:last-child > a,
.pagination-lg > li:last-child > span {
  border-bottom-right-radius: 3px;
  border-top-right-radius: 3px;
}
.pagination-sm > li > a,
.pagination-sm > li > span {
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
}
.pagination-sm > li:first-child > a,
.pagination-sm > li:first-child > span {
  border-bottom-left-radius: 1px;
  border-top-left-radius: 1px;
}
.pagination-sm > li:last-child > a,
.pagination-sm > li:last-child > span {
  border-bottom-right-radius: 1px;
  border-top-right-radius: 1px;
}
.pager {
  padding-left: 0;
  margin: 18px 0;
  list-style: none;
  text-align: center;
}
.pager li {
  display: inline;
}
.pager li > a,
.pager li > span {
  display: inline-block;
  padding: 5px 14px;
  background-color: #fff;
  border: 1px solid #ddd;
  border-radius: 15px;
}
.pager li > a:hover,
.pager li > a:focus {
  text-decoration: none;
  background-color: #eeeeee;
}
.pager .next > a,
.pager .next > span {
  float: right;
}
.pager .previous > a,
.pager .previous > span {
  float: left;
}
.pager .disabled > a,
.pager .disabled > a:hover,
.pager .disabled > a:focus,
.pager .disabled > span {
  color: #777777;
  background-color: #fff;
  cursor: not-allowed;
}
.label {
  display: inline;
  padding: .2em .6em .3em;
  font-size: 75%;
  font-weight: bold;
  line-height: 1;
  color: #fff;
  text-align: center;
  white-space: nowrap;
  vertical-align: baseline;
  border-radius: .25em;
}
a.label:hover,
a.label:focus {
  color: #fff;
  text-decoration: none;
  cursor: pointer;
}
.label:empty {
  display: none;
}
.btn .label {
  position: relative;
  top: -1px;
}
.label-default {
  background-color: #777777;
}
.label-default[href]:hover,
.label-default[href]:focus {
  background-color: #5e5e5e;
}
.label-primary {
  background-color: #337ab7;
}
.label-primary[href]:hover,
.label-primary[href]:focus {
  background-color: #286090;
}
.label-success {
  background-color: #5cb85c;
}
.label-success[href]:hover,
.label-success[href]:focus {
  background-color: #449d44;
}
.label-info {
  background-color: #5bc0de;
}
.label-info[href]:hover,
.label-info[href]:focus {
  background-color: #31b0d5;
}
.label-warning {
  background-color: #f0ad4e;
}
.label-warning[href]:hover,
.label-warning[href]:focus {
  background-color: #ec971f;
}
.label-danger {
  background-color: #d9534f;
}
.label-danger[href]:hover,
.label-danger[href]:focus {
  background-color: #c9302c;
}
.badge {
  display: inline-block;
  min-width: 10px;
  padding: 3px 7px;
  font-size: 12px;
  font-weight: bold;
  color: #fff;
  line-height: 1;
  vertical-align: middle;
  white-space: nowrap;
  text-align: center;
  background-color: #777777;
  border-radius: 10px;
}
.badge:empty {
  display: none;
}
.btn .badge {
  position: relative;
  top: -1px;
}
.btn-xs .badge,
.btn-group-xs > .btn .badge {
  top: 0;
  padding: 1px 5px;
}
a.badge:hover,
a.badge:focus {
  color: #fff;
  text-decoration: none;
  cursor: pointer;
}
.list-group-item.active > .badge,
.nav-pills > .active > a > .badge {
  color: #337ab7;
  background-color: #fff;
}
.list-group-item > .badge {
  float: right;
}
.list-group-item > .badge + .badge {
  margin-right: 5px;
}
.nav-pills > li > a > .badge {
  margin-left: 3px;
}
.jumbotron {
  padding-top: 30px;
  padding-bottom: 30px;
  margin-bottom: 30px;
  color: inherit;
  background-color: #eeeeee;
}
.jumbotron h1,
.jumbotron .h1 {
  color: inherit;
}
.jumbotron p {
  margin-bottom: 15px;
  font-size: 20px;
  font-weight: 200;
}
.jumbotron > hr {
  border-top-color: #d5d5d5;
}
.container .jumbotron,
.container-fluid .jumbotron {
  border-radius: 3px;
  padding-left: 0px;
  padding-right: 0px;
}
.jumbotron .container {
  max-width: 100%;
}
@media screen and (min-width: 768px) {
  .jumbotron {
    padding-top: 48px;
    padding-bottom: 48px;
  }
  .container .jumbotron,
  .container-fluid .jumbotron {
    padding-left: 60px;
    padding-right: 60px;
  }
  .jumbotron h1,
  .jumbotron .h1 {
    font-size: 59px;
  }
}
.thumbnail {
  display: block;
  padding: 4px;
  margin-bottom: 18px;
  line-height: 1.42857143;
  background-color: #fff;
  border: 1px solid #ddd;
  border-radius: 2px;
  -webkit-transition: border 0.2s ease-in-out;
  -o-transition: border 0.2s ease-in-out;
  transition: border 0.2s ease-in-out;
}
.thumbnail > img,
.thumbnail a > img {
  margin-left: auto;
  margin-right: auto;
}
a.thumbnail:hover,
a.thumbnail:focus,
a.thumbnail.active {
  border-color: #337ab7;
}
.thumbnail .caption {
  padding: 9px;
  color: #000;
}
.alert {
  padding: 15px;
  margin-bottom: 18px;
  border: 1px solid transparent;
  border-radius: 2px;
}
.alert h4 {
  margin-top: 0;
  color: inherit;
}
.alert .alert-link {
  font-weight: bold;
}
.alert > p,
.alert > ul {
  margin-bottom: 0;
}
.alert > p + p {
  margin-top: 5px;
}
.alert-dismissable,
.alert-dismissible {
  padding-right: 35px;
}
.alert-dismissable .close,
.alert-dismissible .close {
  position: relative;
  top: -2px;
  right: -21px;
  color: inherit;
}
.alert-success {
  background-color: #dff0d8;
  border-color: #d6e9c6;
  color: #3c763d;
}
.alert-success hr {
  border-top-color: #c9e2b3;
}
.alert-success .alert-link {
  color: #2b542c;
}
.alert-info {
  background-color: #d9edf7;
  border-color: #bce8f1;
  color: #31708f;
}
.alert-info hr {
  border-top-color: #a6e1ec;
}
.alert-info .alert-link {
  color: #245269;
}
.alert-warning {
  background-color: #fcf8e3;
  border-color: #faebcc;
  color: #8a6d3b;
}
.alert-warning hr {
  border-top-color: #f7e1b5;
}
.alert-warning .alert-link {
  color: #66512c;
}
.alert-danger {
  background-color: #f2dede;
  border-color: #ebccd1;
  color: #a94442;
}
.alert-danger hr {
  border-top-color: #e4b9c0;
}
.alert-danger .alert-link {
  color: #843534;
}
@-webkit-keyframes progress-bar-stripes {
  from {
    background-position: 40px 0;
  }
  to {
    background-position: 0 0;
  }
}
@keyframes progress-bar-stripes {
  from {
    background-position: 40px 0;
  }
  to {
    background-position: 0 0;
  }
}
.progress {
  overflow: hidden;
  height: 18px;
  margin-bottom: 18px;
  background-color: #f5f5f5;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 1px 2px rgba(0, 0, 0, 0.1);
  box-shadow: inset 0 1px 2px rgba(0, 0, 0, 0.1);
}
.progress-bar {
  float: left;
  width: 0%;
  height: 100%;
  font-size: 12px;
  line-height: 18px;
  color: #fff;
  text-align: center;
  background-color: #337ab7;
  -webkit-box-shadow: inset 0 -1px 0 rgba(0, 0, 0, 0.15);
  box-shadow: inset 0 -1px 0 rgba(0, 0, 0, 0.15);
  -webkit-transition: width 0.6s ease;
  -o-transition: width 0.6s ease;
  transition: width 0.6s ease;
}
.progress-striped .progress-bar,
.progress-bar-striped {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-size: 40px 40px;
}
.progress.active .progress-bar,
.progress-bar.active {
  -webkit-animation: progress-bar-stripes 2s linear infinite;
  -o-animation: progress-bar-stripes 2s linear infinite;
  animation: progress-bar-stripes 2s linear infinite;
}
.progress-bar-success {
  background-color: #5cb85c;
}
.progress-striped .progress-bar-success {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
}
.progress-bar-info {
  background-color: #5bc0de;
}
.progress-striped .progress-bar-info {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
}
.progress-bar-warning {
  background-color: #f0ad4e;
}
.progress-striped .progress-bar-warning {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
}
.progress-bar-danger {
  background-color: #d9534f;
}
.progress-striped .progress-bar-danger {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
}
.media {
  margin-top: 15px;
}
.media:first-child {
  margin-top: 0;
}
.media,
.media-body {
  zoom: 1;
  overflow: hidden;
}
.media-body {
  width: 10000px;
}
.media-object {
  display: block;
}
.media-object.img-thumbnail {
  max-width: none;
}
.media-right,
.media > .pull-right {
  padding-left: 10px;
}
.media-left,
.media > .pull-left {
  padding-right: 10px;
}
.media-left,
.media-right,
.media-body {
  display: table-cell;
  vertical-align: top;
}
.media-middle {
  vertical-align: middle;
}
.media-bottom {
  vertical-align: bottom;
}
.media-heading {
  margin-top: 0;
  margin-bottom: 5px;
}
.media-list {
  padding-left: 0;
  list-style: none;
}
.list-group {
  margin-bottom: 20px;
  padding-left: 0;
}
.list-group-item {
  position: relative;
  display: block;
  padding: 10px 15px;
  margin-bottom: -1px;
  background-color: #fff;
  border: 1px solid #ddd;
}
.list-group-item:first-child {
  border-top-right-radius: 2px;
  border-top-left-radius: 2px;
}
.list-group-item:last-child {
  margin-bottom: 0;
  border-bottom-right-radius: 2px;
  border-bottom-left-radius: 2px;
}
a.list-group-item,
button.list-group-item {
  color: #555;
}
a.list-group-item .list-group-item-heading,
button.list-group-item .list-group-item-heading {
  color: #333;
}
a.list-group-item:hover,
button.list-group-item:hover,
a.list-group-item:focus,
button.list-group-item:focus {
  text-decoration: none;
  color: #555;
  background-color: #f5f5f5;
}
button.list-group-item {
  width: 100%;
  text-align: left;
}
.list-group-item.disabled,
.list-group-item.disabled:hover,
.list-group-item.disabled:focus {
  background-color: #eeeeee;
  color: #777777;
  cursor: not-allowed;
}
.list-group-item.disabled .list-group-item-heading,
.list-group-item.disabled:hover .list-group-item-heading,
.list-group-item.disabled:focus .list-group-item-heading {
  color: inherit;
}
.list-group-item.disabled .list-group-item-text,
.list-group-item.disabled:hover .list-group-item-text,
.list-group-item.disabled:focus .list-group-item-text {
  color: #777777;
}
.list-group-item.active,
.list-group-item.active:hover,
.list-group-item.active:focus {
  z-index: 2;
  color: #fff;
  background-color: #337ab7;
  border-color: #337ab7;
}
.list-group-item.active .list-group-item-heading,
.list-group-item.active:hover .list-group-item-heading,
.list-group-item.active:focus .list-group-item-heading,
.list-group-item.active .list-group-item-heading > small,
.list-group-item.active:hover .list-group-item-heading > small,
.list-group-item.active:focus .list-group-item-heading > small,
.list-group-item.active .list-group-item-heading > .small,
.list-group-item.active:hover .list-group-item-heading > .small,
.list-group-item.active:focus .list-group-item-heading > .small {
  color: inherit;
}
.list-group-item.active .list-group-item-text,
.list-group-item.active:hover .list-group-item-text,
.list-group-item.active:focus .list-group-item-text {
  color: #c7ddef;
}
.list-group-item-success {
  color: #3c763d;
  background-color: #dff0d8;
}
a.list-group-item-success,
button.list-group-item-success {
  color: #3c763d;
}
a.list-group-item-success .list-group-item-heading,
button.list-group-item-success .list-group-item-heading {
  color: inherit;
}
a.list-group-item-success:hover,
button.list-group-item-success:hover,
a.list-group-item-success:focus,
button.list-group-item-success:focus {
  color: #3c763d;
  background-color: #d0e9c6;
}
a.list-group-item-success.active,
button.list-group-item-success.active,
a.list-group-item-success.active:hover,
button.list-group-item-success.active:hover,
a.list-group-item-success.active:focus,
button.list-group-item-success.active:focus {
  color: #fff;
  background-color: #3c763d;
  border-color: #3c763d;
}
.list-group-item-info {
  color: #31708f;
  background-color: #d9edf7;
}
a.list-group-item-info,
button.list-group-item-info {
  color: #31708f;
}
a.list-group-item-info .list-group-item-heading,
button.list-group-item-info .list-group-item-heading {
  color: inherit;
}
a.list-group-item-info:hover,
button.list-group-item-info:hover,
a.list-group-item-info:focus,
button.list-group-item-info:focus {
  color: #31708f;
  background-color: #c4e3f3;
}
a.list-group-item-info.active,
button.list-group-item-info.active,
a.list-group-item-info.active:hover,
button.list-group-item-info.active:hover,
a.list-group-item-info.active:focus,
button.list-group-item-info.active:focus {
  color: #fff;
  background-color: #31708f;
  border-color: #31708f;
}
.list-group-item-warning {
  color: #8a6d3b;
  background-color: #fcf8e3;
}
a.list-group-item-warning,
button.list-group-item-warning {
  color: #8a6d3b;
}
a.list-group-item-warning .list-group-item-heading,
button.list-group-item-warning .list-group-item-heading {
  color: inherit;
}
a.list-group-item-warning:hover,
button.list-group-item-warning:hover,
a.list-group-item-warning:focus,
button.list-group-item-warning:focus {
  color: #8a6d3b;
  background-color: #faf2cc;
}
a.list-group-item-warning.active,
button.list-group-item-warning.active,
a.list-group-item-warning.active:hover,
button.list-group-item-warning.active:hover,
a.list-group-item-warning.active:focus,
button.list-group-item-warning.active:focus {
  color: #fff;
  background-color: #8a6d3b;
  border-color: #8a6d3b;
}
.list-group-item-danger {
  color: #a94442;
  background-color: #f2dede;
}
a.list-group-item-danger,
button.list-group-item-danger {
  color: #a94442;
}
a.list-group-item-danger .list-group-item-heading,
button.list-group-item-danger .list-group-item-heading {
  color: inherit;
}
a.list-group-item-danger:hover,
button.list-group-item-danger:hover,
a.list-group-item-danger:focus,
button.list-group-item-danger:focus {
  color: #a94442;
  background-color: #ebcccc;
}
a.list-group-item-danger.active,
button.list-group-item-danger.active,
a.list-group-item-danger.active:hover,
button.list-group-item-danger.active:hover,
a.list-group-item-danger.active:focus,
button.list-group-item-danger.active:focus {
  color: #fff;
  background-color: #a94442;
  border-color: #a94442;
}
.list-group-item-heading {
  margin-top: 0;
  margin-bottom: 5px;
}
.list-group-item-text {
  margin-bottom: 0;
  line-height: 1.3;
}
.panel {
  margin-bottom: 18px;
  background-color: #fff;
  border: 1px solid transparent;
  border-radius: 2px;
  -webkit-box-shadow: 0 1px 1px rgba(0, 0, 0, 0.05);
  box-shadow: 0 1px 1px rgba(0, 0, 0, 0.05);
}
.panel-body {
  padding: 15px;
}
.panel-heading {
  padding: 10px 15px;
  border-bottom: 1px solid transparent;
  border-top-right-radius: 1px;
  border-top-left-radius: 1px;
}
.panel-heading > .dropdown .dropdown-toggle {
  color: inherit;
}
.panel-title {
  margin-top: 0;
  margin-bottom: 0;
  font-size: 15px;
  color: inherit;
}
.panel-title > a,
.panel-title > small,
.panel-title > .small,
.panel-title > small > a,
.panel-title > .small > a {
  color: inherit;
}
.panel-footer {
  padding: 10px 15px;
  background-color: #f5f5f5;
  border-top: 1px solid #ddd;
  border-bottom-right-radius: 1px;
  border-bottom-left-radius: 1px;
}
.panel > .list-group,
.panel > .panel-collapse > .list-group {
  margin-bottom: 0;
}
.panel > .list-group .list-group-item,
.panel > .panel-collapse > .list-group .list-group-item {
  border-width: 1px 0;
  border-radius: 0;
}
.panel > .list-group:first-child .list-group-item:first-child,
.panel > .panel-collapse > .list-group:first-child .list-group-item:first-child {
  border-top: 0;
  border-top-right-radius: 1px;
  border-top-left-radius: 1px;
}
.panel > .list-group:last-child .list-group-item:last-child,
.panel > .panel-collapse > .list-group:last-child .list-group-item:last-child {
  border-bottom: 0;
  border-bottom-right-radius: 1px;
  border-bottom-left-radius: 1px;
}
.panel > .panel-heading + .panel-collapse > .list-group .list-group-item:first-child {
  border-top-right-radius: 0;
  border-top-left-radius: 0;
}
.panel-heading + .list-group .list-group-item:first-child {
  border-top-width: 0;
}
.list-group + .panel-footer {
  border-top-width: 0;
}
.panel > .table,
.panel > .table-responsive > .table,
.panel > .panel-collapse > .table {
  margin-bottom: 0;
}
.panel > .table caption,
.panel > .table-responsive > .table caption,
.panel > .panel-collapse > .table caption {
  padding-left: 15px;
  padding-right: 15px;
}
.panel > .table:first-child,
.panel > .table-responsive:first-child > .table:first-child {
  border-top-right-radius: 1px;
  border-top-left-radius: 1px;
}
.panel > .table:first-child > thead:first-child > tr:first-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child,
.panel > .table:first-child > tbody:first-child > tr:first-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child {
  border-top-left-radius: 1px;
  border-top-right-radius: 1px;
}
.panel > .table:first-child > thead:first-child > tr:first-child td:first-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child td:first-child,
.panel > .table:first-child > tbody:first-child > tr:first-child td:first-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child td:first-child,
.panel > .table:first-child > thead:first-child > tr:first-child th:first-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child th:first-child,
.panel > .table:first-child > tbody:first-child > tr:first-child th:first-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child th:first-child {
  border-top-left-radius: 1px;
}
.panel > .table:first-child > thead:first-child > tr:first-child td:last-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child td:last-child,
.panel > .table:first-child > tbody:first-child > tr:first-child td:last-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child td:last-child,
.panel > .table:first-child > thead:first-child > tr:first-child th:last-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child th:last-child,
.panel > .table:first-child > tbody:first-child > tr:first-child th:last-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child th:last-child {
  border-top-right-radius: 1px;
}
.panel > .table:last-child,
.panel > .table-responsive:last-child > .table:last-child {
  border-bottom-right-radius: 1px;
  border-bottom-left-radius: 1px;
}
.panel > .table:last-child > tbody:last-child > tr:last-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child {
  border-bottom-left-radius: 1px;
  border-bottom-right-radius: 1px;
}
.panel > .table:last-child > tbody:last-child > tr:last-child td:first-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child td:first-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child td:first-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child td:first-child,
.panel > .table:last-child > tbody:last-child > tr:last-child th:first-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child th:first-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child th:first-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child th:first-child {
  border-bottom-left-radius: 1px;
}
.panel > .table:last-child > tbody:last-child > tr:last-child td:last-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child td:last-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child td:last-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child td:last-child,
.panel > .table:last-child > tbody:last-child > tr:last-child th:last-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child th:last-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child th:last-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child th:last-child {
  border-bottom-right-radius: 1px;
}
.panel > .panel-body + .table,
.panel > .panel-body + .table-responsive,
.panel > .table + .panel-body,
.panel > .table-responsive + .panel-body {
  border-top: 1px solid #ddd;
}
.panel > .table > tbody:first-child > tr:first-child th,
.panel > .table > tbody:first-child > tr:first-child td {
  border-top: 0;
}
.panel > .table-bordered,
.panel > .table-responsive > .table-bordered {
  border: 0;
}
.panel > .table-bordered > thead > tr > th:first-child,
.panel > .table-responsive > .table-bordered > thead > tr > th:first-child,
.panel > .table-bordered > tbody > tr > th:first-child,
.panel > .table-responsive > .table-bordered > tbody > tr > th:first-child,
.panel > .table-bordered > tfoot > tr > th:first-child,
.panel > .table-responsive > .table-bordered > tfoot > tr > th:first-child,
.panel > .table-bordered > thead > tr > td:first-child,
.panel > .table-responsive > .table-bordered > thead > tr > td:first-child,
.panel > .table-bordered > tbody > tr > td:first-child,
.panel > .table-responsive > .table-bordered > tbody > tr > td:first-child,
.panel > .table-bordered > tfoot > tr > td:first-child,
.panel > .table-responsive > .table-bordered > tfoot > tr > td:first-child {
  border-left: 0;
}
.panel > .table-bordered > thead > tr > th:last-child,
.panel > .table-responsive > .table-bordered > thead > tr > th:last-child,
.panel > .table-bordered > tbody > tr > th:last-child,
.panel > .table-responsive > .table-bordered > tbody > tr > th:last-child,
.panel > .table-bordered > tfoot > tr > th:last-child,
.panel > .table-responsive > .table-bordered > tfoot > tr > th:last-child,
.panel > .table-bordered > thead > tr > td:last-child,
.panel > .table-responsive > .table-bordered > thead > tr > td:last-child,
.panel > .table-bordered > tbody > tr > td:last-child,
.panel > .table-responsive > .table-bordered > tbody > tr > td:last-child,
.panel > .table-bordered > tfoot > tr > td:last-child,
.panel > .table-responsive > .table-bordered > tfoot > tr > td:last-child {
  border-right: 0;
}
.panel > .table-bordered > thead > tr:first-child > td,
.panel > .table-responsive > .table-bordered > thead > tr:first-child > td,
.panel > .table-bordered > tbody > tr:first-child > td,
.panel > .table-responsive > .table-bordered > tbody > tr:first-child > td,
.panel > .table-bordered > thead > tr:first-child > th,
.panel > .table-responsive > .table-bordered > thead > tr:first-child > th,
.panel > .table-bordered > tbody > tr:first-child > th,
.panel > .table-responsive > .table-bordered > tbody > tr:first-child > th {
  border-bottom: 0;
}
.panel > .table-bordered > tbody > tr:last-child > td,
.panel > .table-responsive > .table-bordered > tbody > tr:last-child > td,
.panel > .table-bordered > tfoot > tr:last-child > td,
.panel > .table-responsive > .table-bordered > tfoot > tr:last-child > td,
.panel > .table-bordered > tbody > tr:last-child > th,
.panel > .table-responsive > .table-bordered > tbody > tr:last-child > th,
.panel > .table-bordered > tfoot > tr:last-child > th,
.panel > .table-responsive > .table-bordered > tfoot > tr:last-child > th {
  border-bottom: 0;
}
.panel > .table-responsive {
  border: 0;
  margin-bottom: 0;
}
.panel-group {
  margin-bottom: 18px;
}
.panel-group .panel {
  margin-bottom: 0;
  border-radius: 2px;
}
.panel-group .panel + .panel {
  margin-top: 5px;
}
.panel-group .panel-heading {
  border-bottom: 0;
}
.panel-group .panel-heading + .panel-collapse > .panel-body,
.panel-group .panel-heading + .panel-collapse > .list-group {
  border-top: 1px solid #ddd;
}
.panel-group .panel-footer {
  border-top: 0;
}
.panel-group .panel-footer + .panel-collapse .panel-body {
  border-bottom: 1px solid #ddd;
}
.panel-default {
  border-color: #ddd;
}
.panel-default > .panel-heading {
  color: #333333;
  background-color: #f5f5f5;
  border-color: #ddd;
}
.panel-default > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #ddd;
}
.panel-default > .panel-heading .badge {
  color: #f5f5f5;
  background-color: #333333;
}
.panel-default > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #ddd;
}
.panel-primary {
  border-color: #337ab7;
}
.panel-primary > .panel-heading {
  color: #fff;
  background-color: #337ab7;
  border-color: #337ab7;
}
.panel-primary > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #337ab7;
}
.panel-primary > .panel-heading .badge {
  color: #337ab7;
  background-color: #fff;
}
.panel-primary > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #337ab7;
}
.panel-success {
  border-color: #d6e9c6;
}
.panel-success > .panel-heading {
  color: #3c763d;
  background-color: #dff0d8;
  border-color: #d6e9c6;
}
.panel-success > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #d6e9c6;
}
.panel-success > .panel-heading .badge {
  color: #dff0d8;
  background-color: #3c763d;
}
.panel-success > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #d6e9c6;
}
.panel-info {
  border-color: #bce8f1;
}
.panel-info > .panel-heading {
  color: #31708f;
  background-color: #d9edf7;
  border-color: #bce8f1;
}
.panel-info > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #bce8f1;
}
.panel-info > .panel-heading .badge {
  color: #d9edf7;
  background-color: #31708f;
}
.panel-info > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #bce8f1;
}
.panel-warning {
  border-color: #faebcc;
}
.panel-warning > .panel-heading {
  color: #8a6d3b;
  background-color: #fcf8e3;
  border-color: #faebcc;
}
.panel-warning > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #faebcc;
}
.panel-warning > .panel-heading .badge {
  color: #fcf8e3;
  background-color: #8a6d3b;
}
.panel-warning > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #faebcc;
}
.panel-danger {
  border-color: #ebccd1;
}
.panel-danger > .panel-heading {
  color: #a94442;
  background-color: #f2dede;
  border-color: #ebccd1;
}
.panel-danger > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #ebccd1;
}
.panel-danger > .panel-heading .badge {
  color: #f2dede;
  background-color: #a94442;
}
.panel-danger > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #ebccd1;
}
.embed-responsive {
  position: relative;
  display: block;
  height: 0;
  padding: 0;
  overflow: hidden;
}
.embed-responsive .embed-responsive-item,
.embed-responsive iframe,
.embed-responsive embed,
.embed-responsive object,
.embed-responsive video {
  position: absolute;
  top: 0;
  left: 0;
  bottom: 0;
  height: 100%;
  width: 100%;
  border: 0;
}
.embed-responsive-16by9 {
  padding-bottom: 56.25%;
}
.embed-responsive-4by3 {
  padding-bottom: 75%;
}
.well {
  min-height: 20px;
  padding: 19px;
  margin-bottom: 20px;
  background-color: #f5f5f5;
  border: 1px solid #e3e3e3;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.05);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.05);
}
.well blockquote {
  border-color: #ddd;
  border-color: rgba(0, 0, 0, 0.15);
}
.well-lg {
  padding: 24px;
  border-radius: 3px;
}
.well-sm {
  padding: 9px;
  border-radius: 1px;
}
.close {
  float: right;
  font-size: 19.5px;
  font-weight: bold;
  line-height: 1;
  color: #000;
  text-shadow: 0 1px 0 #fff;
  opacity: 0.2;
  filter: alpha(opacity=20);
}
.close:hover,
.close:focus {
  color: #000;
  text-decoration: none;
  cursor: pointer;
  opacity: 0.5;
  filter: alpha(opacity=50);
}
button.close {
  padding: 0;
  cursor: pointer;
  background: transparent;
  border: 0;
  -webkit-appearance: none;
}
.modal-open {
  overflow: hidden;
}
.modal {
  display: none;
  overflow: hidden;
  position: fixed;
  top: 0;
  right: 0;
  bottom: 0;
  left: 0;
  z-index: 1050;
  -webkit-overflow-scrolling: touch;
  outline: 0;
}
.modal.fade .modal-dialog {
  -webkit-transform: translate(0, -25%);
  -ms-transform: translate(0, -25%);
  -o-transform: translate(0, -25%);
  transform: translate(0, -25%);
  -webkit-transition: -webkit-transform 0.3s ease-out;
  -moz-transition: -moz-transform 0.3s ease-out;
  -o-transition: -o-transform 0.3s ease-out;
  transition: transform 0.3s ease-out;
}
.modal.in .modal-dialog {
  -webkit-transform: translate(0, 0);
  -ms-transform: translate(0, 0);
  -o-transform: translate(0, 0);
  transform: translate(0, 0);
}
.modal-open .modal {
  overflow-x: hidden;
  overflow-y: auto;
}
.modal-dialog {
  position: relative;
  width: auto;
  margin: 10px;
}
.modal-content {
  position: relative;
  background-color: #fff;
  border: 1px solid #999;
  border: 1px solid rgba(0, 0, 0, 0.2);
  border-radius: 3px;
  -webkit-box-shadow: 0 3px 9px rgba(0, 0, 0, 0.5);
  box-shadow: 0 3px 9px rgba(0, 0, 0, 0.5);
  background-clip: padding-box;
  outline: 0;
}
.modal-backdrop {
  position: fixed;
  top: 0;
  right: 0;
  bottom: 0;
  left: 0;
  z-index: 1040;
  background-color: #000;
}
.modal-backdrop.fade {
  opacity: 0;
  filter: alpha(opacity=0);
}
.modal-backdrop.in {
  opacity: 0.5;
  filter: alpha(opacity=50);
}
.modal-header {
  padding: 15px;
  border-bottom: 1px solid #e5e5e5;
}
.modal-header .close {
  margin-top: -2px;
}
.modal-title {
  margin: 0;
  line-height: 1.42857143;
}
.modal-body {
  position: relative;
  padding: 15px;
}
.modal-footer {
  padding: 15px;
  text-align: right;
  border-top: 1px solid #e5e5e5;
}
.modal-footer .btn + .btn {
  margin-left: 5px;
  margin-bottom: 0;
}
.modal-footer .btn-group .btn + .btn {
  margin-left: -1px;
}
.modal-footer .btn-block + .btn-block {
  margin-left: 0;
}
.modal-scrollbar-measure {
  position: absolute;
  top: -9999px;
  width: 50px;
  height: 50px;
  overflow: scroll;
}
@media (min-width: 768px) {
  .modal-dialog {
    width: 600px;
    margin: 30px auto;
  }
  .modal-content {
    -webkit-box-shadow: 0 5px 15px rgba(0, 0, 0, 0.5);
    box-shadow: 0 5px 15px rgba(0, 0, 0, 0.5);
  }
  .modal-sm {
    width: 300px;
  }
}
@media (min-width: 992px) {
  .modal-lg {
    width: 900px;
  }
}
.tooltip {
  position: absolute;
  z-index: 1070;
  display: block;
  font-family: "Helvetica Neue", Helvetica, Arial, sans-serif;
  font-style: normal;
  font-weight: normal;
  letter-spacing: normal;
  line-break: auto;
  line-height: 1.42857143;
  text-align: left;
  text-align: start;
  text-decoration: none;
  text-shadow: none;
  text-transform: none;
  white-space: normal;
  word-break: normal;
  word-spacing: normal;
  word-wrap: normal;
  font-size: 12px;
  opacity: 0;
  filter: alpha(opacity=0);
}
.tooltip.in {
  opacity: 0.9;
  filter: alpha(opacity=90);
}
.tooltip.top {
  margin-top: -3px;
  padding: 5px 0;
}
.tooltip.right {
  margin-left: 3px;
  padding: 0 5px;
}
.tooltip.bottom {
  margin-top: 3px;
  padding: 5px 0;
}
.tooltip.left {
  margin-left: -3px;
  padding: 0 5px;
}
.tooltip-inner {
  max-width: 200px;
  padding: 3px 8px;
  color: #fff;
  text-align: center;
  background-color: #000;
  border-radius: 2px;
}
.tooltip-arrow {
  position: absolute;
  width: 0;
  height: 0;
  border-color: transparent;
  border-style: solid;
}
.tooltip.top .tooltip-arrow {
  bottom: 0;
  left: 50%;
  margin-left: -5px;
  border-width: 5px 5px 0;
  border-top-color: #000;
}
.tooltip.top-left .tooltip-arrow {
  bottom: 0;
  right: 5px;
  margin-bottom: -5px;
  border-width: 5px 5px 0;
  border-top-color: #000;
}
.tooltip.top-right .tooltip-arrow {
  bottom: 0;
  left: 5px;
  margin-bottom: -5px;
  border-width: 5px 5px 0;
  border-top-color: #000;
}
.tooltip.right .tooltip-arrow {
  top: 50%;
  left: 0;
  margin-top: -5px;
  border-width: 5px 5px 5px 0;
  border-right-color: #000;
}
.tooltip.left .tooltip-arrow {
  top: 50%;
  right: 0;
  margin-top: -5px;
  border-width: 5px 0 5px 5px;
  border-left-color: #000;
}
.tooltip.bottom .tooltip-arrow {
  top: 0;
  left: 50%;
  margin-left: -5px;
  border-width: 0 5px 5px;
  border-bottom-color: #000;
}
.tooltip.bottom-left .tooltip-arrow {
  top: 0;
  right: 5px;
  margin-top: -5px;
  border-width: 0 5px 5px;
  border-bottom-color: #000;
}
.tooltip.bottom-right .tooltip-arrow {
  top: 0;
  left: 5px;
  margin-top: -5px;
  border-width: 0 5px 5px;
  border-bottom-color: #000;
}
.popover {
  position: absolute;
  top: 0;
  left: 0;
  z-index: 1060;
  display: none;
  max-width: 276px;
  padding: 1px;
  font-family: "Helvetica Neue", Helvetica, Arial, sans-serif;
  font-style: normal;
  font-weight: normal;
  letter-spacing: normal;
  line-break: auto;
  line-height: 1.42857143;
  text-align: left;
  text-align: start;
  text-decoration: none;
  text-shadow: none;
  text-transform: none;
  white-space: normal;
  word-break: normal;
  word-spacing: normal;
  word-wrap: normal;
  font-size: 13px;
  background-color: #fff;
  background-clip: padding-box;
  border: 1px solid #ccc;
  border: 1px solid rgba(0, 0, 0, 0.2);
  border-radius: 3px;
  -webkit-box-shadow: 0 5px 10px rgba(0, 0, 0, 0.2);
  box-shadow: 0 5px 10px rgba(0, 0, 0, 0.2);
}
.popover.top {
  margin-top: -10px;
}
.popover.right {
  margin-left: 10px;
}
.popover.bottom {
  margin-top: 10px;
}
.popover.left {
  margin-left: -10px;
}
.popover-title {
  margin: 0;
  padding: 8px 14px;
  font-size: 13px;
  background-color: #f7f7f7;
  border-bottom: 1px solid #ebebeb;
  border-radius: 2px 2px 0 0;
}
.popover-content {
  padding: 9px 14px;
}
.popover > .arrow,
.popover > .arrow:after {
  position: absolute;
  display: block;
  width: 0;
  height: 0;
  border-color: transparent;
  border-style: solid;
}
.popover > .arrow {
  border-width: 11px;
}
.popover > .arrow:after {
  border-width: 10px;
  content: "";
}
.popover.top > .arrow {
  left: 50%;
  margin-left: -11px;
  border-bottom-width: 0;
  border-top-color: #999999;
  border-top-color: rgba(0, 0, 0, 0.25);
  bottom: -11px;
}
.popover.top > .arrow:after {
  content: " ";
  bottom: 1px;
  margin-left: -10px;
  border-bottom-width: 0;
  border-top-color: #fff;
}
.popover.right > .arrow {
  top: 50%;
  left: -11px;
  margin-top: -11px;
  border-left-width: 0;
  border-right-color: #999999;
  border-right-color: rgba(0, 0, 0, 0.25);
}
.popover.right > .arrow:after {
  content: " ";
  left: 1px;
  bottom: -10px;
  border-left-width: 0;
  border-right-color: #fff;
}
.popover.bottom > .arrow {
  left: 50%;
  margin-left: -11px;
  border-top-width: 0;
  border-bottom-color: #999999;
  border-bottom-color: rgba(0, 0, 0, 0.25);
  top: -11px;
}
.popover.bottom > .arrow:after {
  content: " ";
  top: 1px;
  margin-left: -10px;
  border-top-width: 0;
  border-bottom-color: #fff;
}
.popover.left > .arrow {
  top: 50%;
  right: -11px;
  margin-top: -11px;
  border-right-width: 0;
  border-left-color: #999999;
  border-left-color: rgba(0, 0, 0, 0.25);
}
.popover.left > .arrow:after {
  content: " ";
  right: 1px;
  border-right-width: 0;
  border-left-color: #fff;
  bottom: -10px;
}
.carousel {
  position: relative;
}
.carousel-inner {
  position: relative;
  overflow: hidden;
  width: 100%;
}
.carousel-inner > .item {
  display: none;
  position: relative;
  -webkit-transition: 0.6s ease-in-out left;
  -o-transition: 0.6s ease-in-out left;
  transition: 0.6s ease-in-out left;
}
.carousel-inner > .item > img,
.carousel-inner > .item > a > img {
  line-height: 1;
}
@media all and (transform-3d), (-webkit-transform-3d) {
  .carousel-inner > .item {
    -webkit-transition: -webkit-transform 0.6s ease-in-out;
    -moz-transition: -moz-transform 0.6s ease-in-out;
    -o-transition: -o-transform 0.6s ease-in-out;
    transition: transform 0.6s ease-in-out;
    -webkit-backface-visibility: hidden;
    -moz-backface-visibility: hidden;
    backface-visibility: hidden;
    -webkit-perspective: 1000px;
    -moz-perspective: 1000px;
    perspective: 1000px;
  }
  .carousel-inner > .item.next,
  .carousel-inner > .item.active.right {
    -webkit-transform: translate3d(100%, 0, 0);
    transform: translate3d(100%, 0, 0);
    left: 0;
  }
  .carousel-inner > .item.prev,
  .carousel-inner > .item.active.left {
    -webkit-transform: translate3d(-100%, 0, 0);
    transform: translate3d(-100%, 0, 0);
    left: 0;
  }
  .carousel-inner > .item.next.left,
  .carousel-inner > .item.prev.right,
  .carousel-inner > .item.active {
    -webkit-transform: translate3d(0, 0, 0);
    transform: translate3d(0, 0, 0);
    left: 0;
  }
}
.carousel-inner > .active,
.carousel-inner > .next,
.carousel-inner > .prev {
  display: block;
}
.carousel-inner > .active {
  left: 0;
}
.carousel-inner > .next,
.carousel-inner > .prev {
  position: absolute;
  top: 0;
  width: 100%;
}
.carousel-inner > .next {
  left: 100%;
}
.carousel-inner > .prev {
  left: -100%;
}
.carousel-inner > .next.left,
.carousel-inner > .prev.right {
  left: 0;
}
.carousel-inner > .active.left {
  left: -100%;
}
.carousel-inner > .active.right {
  left: 100%;
}
.carousel-control {
  position: absolute;
  top: 0;
  left: 0;
  bottom: 0;
  width: 15%;
  opacity: 0.5;
  filter: alpha(opacity=50);
  font-size: 20px;
  color: #fff;
  text-align: center;
  text-shadow: 0 1px 2px rgba(0, 0, 0, 0.6);
  background-color: rgba(0, 0, 0, 0);
}
.carousel-control.left {
  background-image: -webkit-linear-gradient(left, rgba(0, 0, 0, 0.5) 0%, rgba(0, 0, 0, 0.0001) 100%);
  background-image: -o-linear-gradient(left, rgba(0, 0, 0, 0.5) 0%, rgba(0, 0, 0, 0.0001) 100%);
  background-image: linear-gradient(to right, rgba(0, 0, 0, 0.5) 0%, rgba(0, 0, 0, 0.0001) 100%);
  background-repeat: repeat-x;
  filter: progid:DXImageTransform.Microsoft.gradient(startColorstr='#80000000', endColorstr='#00000000', GradientType=1);
}
.carousel-control.right {
  left: auto;
  right: 0;
  background-image: -webkit-linear-gradient(left, rgba(0, 0, 0, 0.0001) 0%, rgba(0, 0, 0, 0.5) 100%);
  background-image: -o-linear-gradient(left, rgba(0, 0, 0, 0.0001) 0%, rgba(0, 0, 0, 0.5) 100%);
  background-image: linear-gradient(to right, rgba(0, 0, 0, 0.0001) 0%, rgba(0, 0, 0, 0.5) 100%);
  background-repeat: repeat-x;
  filter: progid:DXImageTransform.Microsoft.gradient(startColorstr='#00000000', endColorstr='#80000000', GradientType=1);
}
.carousel-control:hover,
.carousel-control:focus {
  outline: 0;
  color: #fff;
  text-decoration: none;
  opacity: 0.9;
  filter: alpha(opacity=90);
}
.carousel-control .icon-prev,
.carousel-control .icon-next,
.carousel-control .glyphicon-chevron-left,
.carousel-control .glyphicon-chevron-right {
  position: absolute;
  top: 50%;
  margin-top: -10px;
  z-index: 5;
  display: inline-block;
}
.carousel-control .icon-prev,
.carousel-control .glyphicon-chevron-left {
  left: 50%;
  margin-left: -10px;
}
.carousel-control .icon-next,
.carousel-control .glyphicon-chevron-right {
  right: 50%;
  margin-right: -10px;
}
.carousel-control .icon-prev,
.carousel-control .icon-next {
  width: 20px;
  height: 20px;
  line-height: 1;
  font-family: serif;
}
.carousel-control .icon-prev:before {
  content: '\2039';
}
.carousel-control .icon-next:before {
  content: '\203a';
}
.carousel-indicators {
  position: absolute;
  bottom: 10px;
  left: 50%;
  z-index: 15;
  width: 60%;
  margin-left: -30%;
  padding-left: 0;
  list-style: none;
  text-align: center;
}
.carousel-indicators li {
  display: inline-block;
  width: 10px;
  height: 10px;
  margin: 1px;
  text-indent: -999px;
  border: 1px solid #fff;
  border-radius: 10px;
  cursor: pointer;
  background-color: #000 \9;
  background-color: rgba(0, 0, 0, 0);
}
.carousel-indicators .active {
  margin: 0;
  width: 12px;
  height: 12px;
  background-color: #fff;
}
.carousel-caption {
  position: absolute;
  left: 15%;
  right: 15%;
  bottom: 20px;
  z-index: 10;
  padding-top: 20px;
  padding-bottom: 20px;
  color: #fff;
  text-align: center;
  text-shadow: 0 1px 2px rgba(0, 0, 0, 0.6);
}
.carousel-caption .btn {
  text-shadow: none;
}
@media screen and (min-width: 768px) {
  .carousel-control .glyphicon-chevron-left,
  .carousel-control .glyphicon-chevron-right,
  .carousel-control .icon-prev,
  .carousel-control .icon-next {
    width: 30px;
    height: 30px;
    margin-top: -10px;
    font-size: 30px;
  }
  .carousel-control .glyphicon-chevron-left,
  .carousel-control .icon-prev {
    margin-left: -10px;
  }
  .carousel-control .glyphicon-chevron-right,
  .carousel-control .icon-next {
    margin-right: -10px;
  }
  .carousel-caption {
    left: 20%;
    right: 20%;
    padding-bottom: 30px;
  }
  .carousel-indicators {
    bottom: 20px;
  }
}
.clearfix:before,
.clearfix:after,
.dl-horizontal dd:before,
.dl-horizontal dd:after,
.container:before,
.container:after,
.container-fluid:before,
.container-fluid:after,
.row:before,
.row:after,
.form-horizontal .form-group:before,
.form-horizontal .form-group:after,
.btn-toolbar:before,
.btn-toolbar:after,
.btn-group-vertical > .btn-group:before,
.btn-group-vertical > .btn-group:after,
.nav:before,
.nav:after,
.navbar:before,
.navbar:after,
.navbar-header:before,
.navbar-header:after,
.navbar-collapse:before,
.navbar-collapse:after,
.pager:before,
.pager:after,
.panel-body:before,
.panel-body:after,
.modal-header:before,
.modal-header:after,
.modal-footer:before,
.modal-footer:after,
.item_buttons:before,
.item_buttons:after {
  content: " ";
  display: table;
}
.clearfix:after,
.dl-horizontal dd:after,
.container:after,
.container-fluid:after,
.row:after,
.form-horizontal .form-group:after,
.btn-toolbar:after,
.btn-group-vertical > .btn-group:after,
.nav:after,
.navbar:after,
.navbar-header:after,
.navbar-collapse:after,
.pager:after,
.panel-body:after,
.modal-header:after,
.modal-footer:after,
.item_buttons:after {
  clear: both;
}
.center-block {
  display: block;
  margin-left: auto;
  margin-right: auto;
}
.pull-right {
  float: right !important;
}
.pull-left {
  float: left !important;
}
.hide {
  display: none !important;
}
.show {
  display: block !important;
}
.invisible {
  visibility: hidden;
}
.text-hide {
  font: 0/0 a;
  color: transparent;
  text-shadow: none;
  background-color: transparent;
  border: 0;
}
.hidden {
  display: none !important;
}
.affix {
  position: fixed;
}
@-ms-viewport {
  width: device-width;
}
.visible-xs,
.visible-sm,
.visible-md,
.visible-lg {
  display: none !important;
}
.visible-xs-block,
.visible-xs-inline,
.visible-xs-inline-block,
.visible-sm-block,
.visible-sm-inline,
.visible-sm-inline-block,
.visible-md-block,
.visible-md-inline,
.visible-md-inline-block,
.visible-lg-block,
.visible-lg-inline,
.visible-lg-inline-block {
  display: none !important;
}
@media (max-width: 767px) {
  .visible-xs {
    display: block !important;
  }
  table.visible-xs {
    display: table !important;
  }
  tr.visible-xs {
    display: table-row !important;
  }
  th.visible-xs,
  td.visible-xs {
    display: table-cell !important;
  }
}
@media (max-width: 767px) {
  .visible-xs-block {
    display: block !important;
  }
}
@media (max-width: 767px) {
  .visible-xs-inline {
    display: inline !important;
  }
}
@media (max-width: 767px) {
  .visible-xs-inline-block {
    display: inline-block !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .visible-sm {
    display: block !important;
  }
  table.visible-sm {
    display: table !important;
  }
  tr.visible-sm {
    display: table-row !important;
  }
  th.visible-sm,
  td.visible-sm {
    display: table-cell !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .visible-sm-block {
    display: block !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .visible-sm-inline {
    display: inline !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .visible-sm-inline-block {
    display: inline-block !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .visible-md {
    display: block !important;
  }
  table.visible-md {
    display: table !important;
  }
  tr.visible-md {
    display: table-row !important;
  }
  th.visible-md,
  td.visible-md {
    display: table-cell !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .visible-md-block {
    display: block !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .visible-md-inline {
    display: inline !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .visible-md-inline-block {
    display: inline-block !important;
  }
}
@media (min-width: 1200px) {
  .visible-lg {
    display: block !important;
  }
  table.visible-lg {
    display: table !important;
  }
  tr.visible-lg {
    display: table-row !important;
  }
  th.visible-lg,
  td.visible-lg {
    display: table-cell !important;
  }
}
@media (min-width: 1200px) {
  .visible-lg-block {
    display: block !important;
  }
}
@media (min-width: 1200px) {
  .visible-lg-inline {
    display: inline !important;
  }
}
@media (min-width: 1200px) {
  .visible-lg-inline-block {
    display: inline-block !important;
  }
}
@media (max-width: 767px) {
  .hidden-xs {
    display: none !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .hidden-sm {
    display: none !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .hidden-md {
    display: none !important;
  }
}
@media (min-width: 1200px) {
  .hidden-lg {
    display: none !important;
  }
}
.visible-print {
  display: none !important;
}
@media print {
  .visible-print {
    display: block !important;
  }
  table.visible-print {
    display: table !important;
  }
  tr.visible-print {
    display: table-row !important;
  }
  th.visible-print,
  td.visible-print {
    display: table-cell !important;
  }
}
.visible-print-block {
  display: none !important;
}
@media print {
  .visible-print-block {
    display: block !important;
  }
}
.visible-print-inline {
  display: none !important;
}
@media print {
  .visible-print-inline {
    display: inline !important;
  }
}
.visible-print-inline-block {
  display: none !important;
}
@media print {
  .visible-print-inline-block {
    display: inline-block !important;
  }
}
@media print {
  .hidden-print {
    display: none !important;
  }
}
/*!
*
* Font Awesome
*
*/
/*!
 *  Font Awesome 4.2.0 by @davegandy - http://fontawesome.io - @fontawesome
 *  License - http://fontawesome.io/license (Font: SIL OFL 1.1, CSS: MIT License)
 */
/* FONT PATH
 * -------------------------- */
@font-face {
  font-family: 'FontAwesome';
  src: url('../components/font-awesome/fonts/fontawesome-webfont.eot?v=4.2.0');
  src: url('../components/font-awesome/fonts/fontawesome-webfont.eot?#iefix&v=4.2.0') format('embedded-opentype'), url('../components/font-awesome/fonts/fontawesome-webfont.woff?v=4.2.0') format('woff'), url('../components/font-awesome/fonts/fontawesome-webfont.ttf?v=4.2.0') format('truetype'), url('../components/font-awesome/fonts/fontawesome-webfont.svg?v=4.2.0#fontawesomeregular') format('svg');
  font-weight: normal;
  font-style: normal;
}
.fa {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
}
/* makes the font 33% larger relative to the icon container */
.fa-lg {
  font-size: 1.33333333em;
  line-height: 0.75em;
  vertical-align: -15%;
}
.fa-2x {
  font-size: 2em;
}
.fa-3x {
  font-size: 3em;
}
.fa-4x {
  font-size: 4em;
}
.fa-5x {
  font-size: 5em;
}
.fa-fw {
  width: 1.28571429em;
  text-align: center;
}
.fa-ul {
  padding-left: 0;
  margin-left: 2.14285714em;
  list-style-type: none;
}
.fa-ul > li {
  position: relative;
}
.fa-li {
  position: absolute;
  left: -2.14285714em;
  width: 2.14285714em;
  top: 0.14285714em;
  text-align: center;
}
.fa-li.fa-lg {
  left: -1.85714286em;
}
.fa-border {
  padding: .2em .25em .15em;
  border: solid 0.08em #eee;
  border-radius: .1em;
}
.pull-right {
  float: right;
}
.pull-left {
  float: left;
}
.fa.pull-left {
  margin-right: .3em;
}
.fa.pull-right {
  margin-left: .3em;
}
.fa-spin {
  -webkit-animation: fa-spin 2s infinite linear;
  animation: fa-spin 2s infinite linear;
}
@-webkit-keyframes fa-spin {
  0% {
    -webkit-transform: rotate(0deg);
    transform: rotate(0deg);
  }
  100% {
    -webkit-transform: rotate(359deg);
    transform: rotate(359deg);
  }
}
@keyframes fa-spin {
  0% {
    -webkit-transform: rotate(0deg);
    transform: rotate(0deg);
  }
  100% {
    -webkit-transform: rotate(359deg);
    transform: rotate(359deg);
  }
}
.fa-rotate-90 {
  filter: progid:DXImageTransform.Microsoft.BasicImage(rotation=1);
  -webkit-transform: rotate(90deg);
  -ms-transform: rotate(90deg);
  transform: rotate(90deg);
}
.fa-rotate-180 {
  filter: progid:DXImageTransform.Microsoft.BasicImage(rotation=2);
  -webkit-transform: rotate(180deg);
  -ms-transform: rotate(180deg);
  transform: rotate(180deg);
}
.fa-rotate-270 {
  filter: progid:DXImageTransform.Microsoft.BasicImage(rotation=3);
  -webkit-transform: rotate(270deg);
  -ms-transform: rotate(270deg);
  transform: rotate(270deg);
}
.fa-flip-horizontal {
  filter: progid:DXImageTransform.Microsoft.BasicImage(rotation=0, mirror=1);
  -webkit-transform: scale(-1, 1);
  -ms-transform: scale(-1, 1);
  transform: scale(-1, 1);
}
.fa-flip-vertical {
  filter: progid:DXImageTransform.Microsoft.BasicImage(rotation=2, mirror=1);
  -webkit-transform: scale(1, -1);
  -ms-transform: scale(1, -1);
  transform: scale(1, -1);
}
:root .fa-rotate-90,
:root .fa-rotate-180,
:root .fa-rotate-270,
:root .fa-flip-horizontal,
:root .fa-flip-vertical {
  filter: none;
}
.fa-stack {
  position: relative;
  display: inline-block;
  width: 2em;
  height: 2em;
  line-height: 2em;
  vertical-align: middle;
}
.fa-stack-1x,
.fa-stack-2x {
  position: absolute;
  left: 0;
  width: 100%;
  text-align: center;
}
.fa-stack-1x {
  line-height: inherit;
}
.fa-stack-2x {
  font-size: 2em;
}
.fa-inverse {
  color: #fff;
}
/* Font Awesome uses the Unicode Private Use Area (PUA) to ensure screen
   readers do not read off random characters that represent icons */
.fa-glass:before {
  content: "\f000";
}
.fa-music:before {
  content: "\f001";
}
.fa-search:before {
  content: "\f002";
}
.fa-envelope-o:before {
  content: "\f003";
}
.fa-heart:before {
  content: "\f004";
}
.fa-star:before {
  content: "\f005";
}
.fa-star-o:before {
  content: "\f006";
}
.fa-user:before {
  content: "\f007";
}
.fa-film:before {
  content: "\f008";
}
.fa-th-large:before {
  content: "\f009";
}
.fa-th:before {
  content: "\f00a";
}
.fa-th-list:before {
  content: "\f00b";
}
.fa-check:before {
  content: "\f00c";
}
.fa-remove:before,
.fa-close:before,
.fa-times:before {
  content: "\f00d";
}
.fa-search-plus:before {
  content: "\f00e";
}
.fa-search-minus:before {
  content: "\f010";
}
.fa-power-off:before {
  content: "\f011";
}
.fa-signal:before {
  content: "\f012";
}
.fa-gear:before,
.fa-cog:before {
  content: "\f013";
}
.fa-trash-o:before {
  content: "\f014";
}
.fa-home:before {
  content: "\f015";
}
.fa-file-o:before {
  content: "\f016";
}
.fa-clock-o:before {
  content: "\f017";
}
.fa-road:before {
  content: "\f018";
}
.fa-download:before {
  content: "\f019";
}
.fa-arrow-circle-o-down:before {
  content: "\f01a";
}
.fa-arrow-circle-o-up:before {
  content: "\f01b";
}
.fa-inbox:before {
  content: "\f01c";
}
.fa-play-circle-o:before {
  content: "\f01d";
}
.fa-rotate-right:before,
.fa-repeat:before {
  content: "\f01e";
}
.fa-refresh:before {
  content: "\f021";
}
.fa-list-alt:before {
  content: "\f022";
}
.fa-lock:before {
  content: "\f023";
}
.fa-flag:before {
  content: "\f024";
}
.fa-headphones:before {
  content: "\f025";
}
.fa-volume-off:before {
  content: "\f026";
}
.fa-volume-down:before {
  content: "\f027";
}
.fa-volume-up:before {
  content: "\f028";
}
.fa-qrcode:before {
  content: "\f029";
}
.fa-barcode:before {
  content: "\f02a";
}
.fa-tag:before {
  content: "\f02b";
}
.fa-tags:before {
  content: "\f02c";
}
.fa-book:before {
  content: "\f02d";
}
.fa-bookmark:before {
  content: "\f02e";
}
.fa-print:before {
  content: "\f02f";
}
.fa-camera:before {
  content: "\f030";
}
.fa-font:before {
  content: "\f031";
}
.fa-bold:before {
  content: "\f032";
}
.fa-italic:before {
  content: "\f033";
}
.fa-text-height:before {
  content: "\f034";
}
.fa-text-width:before {
  content: "\f035";
}
.fa-align-left:before {
  content: "\f036";
}
.fa-align-center:before {
  content: "\f037";
}
.fa-align-right:before {
  content: "\f038";
}
.fa-align-justify:before {
  content: "\f039";
}
.fa-list:before {
  content: "\f03a";
}
.fa-dedent:before,
.fa-outdent:before {
  content: "\f03b";
}
.fa-indent:before {
  content: "\f03c";
}
.fa-video-camera:before {
  content: "\f03d";
}
.fa-photo:before,
.fa-image:before,
.fa-picture-o:before {
  content: "\f03e";
}
.fa-pencil:before {
  content: "\f040";
}
.fa-map-marker:before {
  content: "\f041";
}
.fa-adjust:before {
  content: "\f042";
}
.fa-tint:before {
  content: "\f043";
}
.fa-edit:before,
.fa-pencil-square-o:before {
  content: "\f044";
}
.fa-share-square-o:before {
  content: "\f045";
}
.fa-check-square-o:before {
  content: "\f046";
}
.fa-arrows:before {
  content: "\f047";
}
.fa-step-backward:before {
  content: "\f048";
}
.fa-fast-backward:before {
  content: "\f049";
}
.fa-backward:before {
  content: "\f04a";
}
.fa-play:before {
  content: "\f04b";
}
.fa-pause:before {
  content: "\f04c";
}
.fa-stop:before {
  content: "\f04d";
}
.fa-forward:before {
  content: "\f04e";
}
.fa-fast-forward:before {
  content: "\f050";
}
.fa-step-forward:before {
  content: "\f051";
}
.fa-eject:before {
  content: "\f052";
}
.fa-chevron-left:before {
  content: "\f053";
}
.fa-chevron-right:before {
  content: "\f054";
}
.fa-plus-circle:before {
  content: "\f055";
}
.fa-minus-circle:before {
  content: "\f056";
}
.fa-times-circle:before {
  content: "\f057";
}
.fa-check-circle:before {
  content: "\f058";
}
.fa-question-circle:before {
  content: "\f059";
}
.fa-info-circle:before {
  content: "\f05a";
}
.fa-crosshairs:before {
  content: "\f05b";
}
.fa-times-circle-o:before {
  content: "\f05c";
}
.fa-check-circle-o:before {
  content: "\f05d";
}
.fa-ban:before {
  content: "\f05e";
}
.fa-arrow-left:before {
  content: "\f060";
}
.fa-arrow-right:before {
  content: "\f061";
}
.fa-arrow-up:before {
  content: "\f062";
}
.fa-arrow-down:before {
  content: "\f063";
}
.fa-mail-forward:before,
.fa-share:before {
  content: "\f064";
}
.fa-expand:before {
  content: "\f065";
}
.fa-compress:before {
  content: "\f066";
}
.fa-plus:before {
  content: "\f067";
}
.fa-minus:before {
  content: "\f068";
}
.fa-asterisk:before {
  content: "\f069";
}
.fa-exclamation-circle:before {
  content: "\f06a";
}
.fa-gift:before {
  content: "\f06b";
}
.fa-leaf:before {
  content: "\f06c";
}
.fa-fire:before {
  content: "\f06d";
}
.fa-eye:before {
  content: "\f06e";
}
.fa-eye-slash:before {
  content: "\f070";
}
.fa-warning:before,
.fa-exclamation-triangle:before {
  content: "\f071";
}
.fa-plane:before {
  content: "\f072";
}
.fa-calendar:before {
  content: "\f073";
}
.fa-random:before {
  content: "\f074";
}
.fa-comment:before {
  content: "\f075";
}
.fa-magnet:before {
  content: "\f076";
}
.fa-chevron-up:before {
  content: "\f077";
}
.fa-chevron-down:before {
  content: "\f078";
}
.fa-retweet:before {
  content: "\f079";
}
.fa-shopping-cart:before {
  content: "\f07a";
}
.fa-folder:before {
  content: "\f07b";
}
.fa-folder-open:before {
  content: "\f07c";
}
.fa-arrows-v:before {
  content: "\f07d";
}
.fa-arrows-h:before {
  content: "\f07e";
}
.fa-bar-chart-o:before,
.fa-bar-chart:before {
  content: "\f080";
}
.fa-twitter-square:before {
  content: "\f081";
}
.fa-facebook-square:before {
  content: "\f082";
}
.fa-camera-retro:before {
  content: "\f083";
}
.fa-key:before {
  content: "\f084";
}
.fa-gears:before,
.fa-cogs:before {
  content: "\f085";
}
.fa-comments:before {
  content: "\f086";
}
.fa-thumbs-o-up:before {
  content: "\f087";
}
.fa-thumbs-o-down:before {
  content: "\f088";
}
.fa-star-half:before {
  content: "\f089";
}
.fa-heart-o:before {
  content: "\f08a";
}
.fa-sign-out:before {
  content: "\f08b";
}
.fa-linkedin-square:before {
  content: "\f08c";
}
.fa-thumb-tack:before {
  content: "\f08d";
}
.fa-external-link:before {
  content: "\f08e";
}
.fa-sign-in:before {
  content: "\f090";
}
.fa-trophy:before {
  content: "\f091";
}
.fa-github-square:before {
  content: "\f092";
}
.fa-upload:before {
  content: "\f093";
}
.fa-lemon-o:before {
  content: "\f094";
}
.fa-phone:before {
  content: "\f095";
}
.fa-square-o:before {
  content: "\f096";
}
.fa-bookmark-o:before {
  content: "\f097";
}
.fa-phone-square:before {
  content: "\f098";
}
.fa-twitter:before {
  content: "\f099";
}
.fa-facebook:before {
  content: "\f09a";
}
.fa-github:before {
  content: "\f09b";
}
.fa-unlock:before {
  content: "\f09c";
}
.fa-credit-card:before {
  content: "\f09d";
}
.fa-rss:before {
  content: "\f09e";
}
.fa-hdd-o:before {
  content: "\f0a0";
}
.fa-bullhorn:before {
  content: "\f0a1";
}
.fa-bell:before {
  content: "\f0f3";
}
.fa-certificate:before {
  content: "\f0a3";
}
.fa-hand-o-right:before {
  content: "\f0a4";
}
.fa-hand-o-left:before {
  content: "\f0a5";
}
.fa-hand-o-up:before {
  content: "\f0a6";
}
.fa-hand-o-down:before {
  content: "\f0a7";
}
.fa-arrow-circle-left:before {
  content: "\f0a8";
}
.fa-arrow-circle-right:before {
  content: "\f0a9";
}
.fa-arrow-circle-up:before {
  content: "\f0aa";
}
.fa-arrow-circle-down:before {
  content: "\f0ab";
}
.fa-globe:before {
  content: "\f0ac";
}
.fa-wrench:before {
  content: "\f0ad";
}
.fa-tasks:before {
  content: "\f0ae";
}
.fa-filter:before {
  content: "\f0b0";
}
.fa-briefcase:before {
  content: "\f0b1";
}
.fa-arrows-alt:before {
  content: "\f0b2";
}
.fa-group:before,
.fa-users:before {
  content: "\f0c0";
}
.fa-chain:before,
.fa-link:before {
  content: "\f0c1";
}
.fa-cloud:before {
  content: "\f0c2";
}
.fa-flask:before {
  content: "\f0c3";
}
.fa-cut:before,
.fa-scissors:before {
  content: "\f0c4";
}
.fa-copy:before,
.fa-files-o:before {
  content: "\f0c5";
}
.fa-paperclip:before {
  content: "\f0c6";
}
.fa-save:before,
.fa-floppy-o:before {
  content: "\f0c7";
}
.fa-square:before {
  content: "\f0c8";
}
.fa-navicon:before,
.fa-reorder:before,
.fa-bars:before {
  content: "\f0c9";
}
.fa-list-ul:before {
  content: "\f0ca";
}
.fa-list-ol:before {
  content: "\f0cb";
}
.fa-strikethrough:before {
  content: "\f0cc";
}
.fa-underline:before {
  content: "\f0cd";
}
.fa-table:before {
  content: "\f0ce";
}
.fa-magic:before {
  content: "\f0d0";
}
.fa-truck:before {
  content: "\f0d1";
}
.fa-pinterest:before {
  content: "\f0d2";
}
.fa-pinterest-square:before {
  content: "\f0d3";
}
.fa-google-plus-square:before {
  content: "\f0d4";
}
.fa-google-plus:before {
  content: "\f0d5";
}
.fa-money:before {
  content: "\f0d6";
}
.fa-caret-down:before {
  content: "\f0d7";
}
.fa-caret-up:before {
  content: "\f0d8";
}
.fa-caret-left:before {
  content: "\f0d9";
}
.fa-caret-right:before {
  content: "\f0da";
}
.fa-columns:before {
  content: "\f0db";
}
.fa-unsorted:before,
.fa-sort:before {
  content: "\f0dc";
}
.fa-sort-down:before,
.fa-sort-desc:before {
  content: "\f0dd";
}
.fa-sort-up:before,
.fa-sort-asc:before {
  content: "\f0de";
}
.fa-envelope:before {
  content: "\f0e0";
}
.fa-linkedin:before {
  content: "\f0e1";
}
.fa-rotate-left:before,
.fa-undo:before {
  content: "\f0e2";
}
.fa-legal:before,
.fa-gavel:before {
  content: "\f0e3";
}
.fa-dashboard:before,
.fa-tachometer:before {
  content: "\f0e4";
}
.fa-comment-o:before {
  content: "\f0e5";
}
.fa-comments-o:before {
  content: "\f0e6";
}
.fa-flash:before,
.fa-bolt:before {
  content: "\f0e7";
}
.fa-sitemap:before {
  content: "\f0e8";
}
.fa-umbrella:before {
  content: "\f0e9";
}
.fa-paste:before,
.fa-clipboard:before {
  content: "\f0ea";
}
.fa-lightbulb-o:before {
  content: "\f0eb";
}
.fa-exchange:before {
  content: "\f0ec";
}
.fa-cloud-download:before {
  content: "\f0ed";
}
.fa-cloud-upload:before {
  content: "\f0ee";
}
.fa-user-md:before {
  content: "\f0f0";
}
.fa-stethoscope:before {
  content: "\f0f1";
}
.fa-suitcase:before {
  content: "\f0f2";
}
.fa-bell-o:before {
  content: "\f0a2";
}
.fa-coffee:before {
  content: "\f0f4";
}
.fa-cutlery:before {
  content: "\f0f5";
}
.fa-file-text-o:before {
  content: "\f0f6";
}
.fa-building-o:before {
  content: "\f0f7";
}
.fa-hospital-o:before {
  content: "\f0f8";
}
.fa-ambulance:before {
  content: "\f0f9";
}
.fa-medkit:before {
  content: "\f0fa";
}
.fa-fighter-jet:before {
  content: "\f0fb";
}
.fa-beer:before {
  content: "\f0fc";
}
.fa-h-square:before {
  content: "\f0fd";
}
.fa-plus-square:before {
  content: "\f0fe";
}
.fa-angle-double-left:before {
  content: "\f100";
}
.fa-angle-double-right:before {
  content: "\f101";
}
.fa-angle-double-up:before {
  content: "\f102";
}
.fa-angle-double-down:before {
  content: "\f103";
}
.fa-angle-left:before {
  content: "\f104";
}
.fa-angle-right:before {
  content: "\f105";
}
.fa-angle-up:before {
  content: "\f106";
}
.fa-angle-down:before {
  content: "\f107";
}
.fa-desktop:before {
  content: "\f108";
}
.fa-laptop:before {
  content: "\f109";
}
.fa-tablet:before {
  content: "\f10a";
}
.fa-mobile-phone:before,
.fa-mobile:before {
  content: "\f10b";
}
.fa-circle-o:before {
  content: "\f10c";
}
.fa-quote-left:before {
  content: "\f10d";
}
.fa-quote-right:before {
  content: "\f10e";
}
.fa-spinner:before {
  content: "\f110";
}
.fa-circle:before {
  content: "\f111";
}
.fa-mail-reply:before,
.fa-reply:before {
  content: "\f112";
}
.fa-github-alt:before {
  content: "\f113";
}
.fa-folder-o:before {
  content: "\f114";
}
.fa-folder-open-o:before {
  content: "\f115";
}
.fa-smile-o:before {
  content: "\f118";
}
.fa-frown-o:before {
  content: "\f119";
}
.fa-meh-o:before {
  content: "\f11a";
}
.fa-gamepad:before {
  content: "\f11b";
}
.fa-keyboard-o:before {
  content: "\f11c";
}
.fa-flag-o:before {
  content: "\f11d";
}
.fa-flag-checkered:before {
  content: "\f11e";
}
.fa-terminal:before {
  content: "\f120";
}
.fa-code:before {
  content: "\f121";
}
.fa-mail-reply-all:before,
.fa-reply-all:before {
  content: "\f122";
}
.fa-star-half-empty:before,
.fa-star-half-full:before,
.fa-star-half-o:before {
  content: "\f123";
}
.fa-location-arrow:before {
  content: "\f124";
}
.fa-crop:before {
  content: "\f125";
}
.fa-code-fork:before {
  content: "\f126";
}
.fa-unlink:before,
.fa-chain-broken:before {
  content: "\f127";
}
.fa-question:before {
  content: "\f128";
}
.fa-info:before {
  content: "\f129";
}
.fa-exclamation:before {
  content: "\f12a";
}
.fa-superscript:before {
  content: "\f12b";
}
.fa-subscript:before {
  content: "\f12c";
}
.fa-eraser:before {
  content: "\f12d";
}
.fa-puzzle-piece:before {
  content: "\f12e";
}
.fa-microphone:before {
  content: "\f130";
}
.fa-microphone-slash:before {
  content: "\f131";
}
.fa-shield:before {
  content: "\f132";
}
.fa-calendar-o:before {
  content: "\f133";
}
.fa-fire-extinguisher:before {
  content: "\f134";
}
.fa-rocket:before {
  content: "\f135";
}
.fa-maxcdn:before {
  content: "\f136";
}
.fa-chevron-circle-left:before {
  content: "\f137";
}
.fa-chevron-circle-right:before {
  content: "\f138";
}
.fa-chevron-circle-up:before {
  content: "\f139";
}
.fa-chevron-circle-down:before {
  content: "\f13a";
}
.fa-html5:before {
  content: "\f13b";
}
.fa-css3:before {
  content: "\f13c";
}
.fa-anchor:before {
  content: "\f13d";
}
.fa-unlock-alt:before {
  content: "\f13e";
}
.fa-bullseye:before {
  content: "\f140";
}
.fa-ellipsis-h:before {
  content: "\f141";
}
.fa-ellipsis-v:before {
  content: "\f142";
}
.fa-rss-square:before {
  content: "\f143";
}
.fa-play-circle:before {
  content: "\f144";
}
.fa-ticket:before {
  content: "\f145";
}
.fa-minus-square:before {
  content: "\f146";
}
.fa-minus-square-o:before {
  content: "\f147";
}
.fa-level-up:before {
  content: "\f148";
}
.fa-level-down:before {
  content: "\f149";
}
.fa-check-square:before {
  content: "\f14a";
}
.fa-pencil-square:before {
  content: "\f14b";
}
.fa-external-link-square:before {
  content: "\f14c";
}
.fa-share-square:before {
  content: "\f14d";
}
.fa-compass:before {
  content: "\f14e";
}
.fa-toggle-down:before,
.fa-caret-square-o-down:before {
  content: "\f150";
}
.fa-toggle-up:before,
.fa-caret-square-o-up:before {
  content: "\f151";
}
.fa-toggle-right:before,
.fa-caret-square-o-right:before {
  content: "\f152";
}
.fa-euro:before,
.fa-eur:before {
  content: "\f153";
}
.fa-gbp:before {
  content: "\f154";
}
.fa-dollar:before,
.fa-usd:before {
  content: "\f155";
}
.fa-rupee:before,
.fa-inr:before {
  content: "\f156";
}
.fa-cny:before,
.fa-rmb:before,
.fa-yen:before,
.fa-jpy:before {
  content: "\f157";
}
.fa-ruble:before,
.fa-rouble:before,
.fa-rub:before {
  content: "\f158";
}
.fa-won:before,
.fa-krw:before {
  content: "\f159";
}
.fa-bitcoin:before,
.fa-btc:before {
  content: "\f15a";
}
.fa-file:before {
  content: "\f15b";
}
.fa-file-text:before {
  content: "\f15c";
}
.fa-sort-alpha-asc:before {
  content: "\f15d";
}
.fa-sort-alpha-desc:before {
  content: "\f15e";
}
.fa-sort-amount-asc:before {
  content: "\f160";
}
.fa-sort-amount-desc:before {
  content: "\f161";
}
.fa-sort-numeric-asc:before {
  content: "\f162";
}
.fa-sort-numeric-desc:before {
  content: "\f163";
}
.fa-thumbs-up:before {
  content: "\f164";
}
.fa-thumbs-down:before {
  content: "\f165";
}
.fa-youtube-square:before {
  content: "\f166";
}
.fa-youtube:before {
  content: "\f167";
}
.fa-xing:before {
  content: "\f168";
}
.fa-xing-square:before {
  content: "\f169";
}
.fa-youtube-play:before {
  content: "\f16a";
}
.fa-dropbox:before {
  content: "\f16b";
}
.fa-stack-overflow:before {
  content: "\f16c";
}
.fa-instagram:before {
  content: "\f16d";
}
.fa-flickr:before {
  content: "\f16e";
}
.fa-adn:before {
  content: "\f170";
}
.fa-bitbucket:before {
  content: "\f171";
}
.fa-bitbucket-square:before {
  content: "\f172";
}
.fa-tumblr:before {
  content: "\f173";
}
.fa-tumblr-square:before {
  content: "\f174";
}
.fa-long-arrow-down:before {
  content: "\f175";
}
.fa-long-arrow-up:before {
  content: "\f176";
}
.fa-long-arrow-left:before {
  content: "\f177";
}
.fa-long-arrow-right:before {
  content: "\f178";
}
.fa-apple:before {
  content: "\f179";
}
.fa-windows:before {
  content: "\f17a";
}
.fa-android:before {
  content: "\f17b";
}
.fa-linux:before {
  content: "\f17c";
}
.fa-dribbble:before {
  content: "\f17d";
}
.fa-skype:before {
  content: "\f17e";
}
.fa-foursquare:before {
  content: "\f180";
}
.fa-trello:before {
  content: "\f181";
}
.fa-female:before {
  content: "\f182";
}
.fa-male:before {
  content: "\f183";
}
.fa-gittip:before {
  content: "\f184";
}
.fa-sun-o:before {
  content: "\f185";
}
.fa-moon-o:before {
  content: "\f186";
}
.fa-archive:before {
  content: "\f187";
}
.fa-bug:before {
  content: "\f188";
}
.fa-vk:before {
  content: "\f189";
}
.fa-weibo:before {
  content: "\f18a";
}
.fa-renren:before {
  content: "\f18b";
}
.fa-pagelines:before {
  content: "\f18c";
}
.fa-stack-exchange:before {
  content: "\f18d";
}
.fa-arrow-circle-o-right:before {
  content: "\f18e";
}
.fa-arrow-circle-o-left:before {
  content: "\f190";
}
.fa-toggle-left:before,
.fa-caret-square-o-left:before {
  content: "\f191";
}
.fa-dot-circle-o:before {
  content: "\f192";
}
.fa-wheelchair:before {
  content: "\f193";
}
.fa-vimeo-square:before {
  content: "\f194";
}
.fa-turkish-lira:before,
.fa-try:before {
  content: "\f195";
}
.fa-plus-square-o:before {
  content: "\f196";
}
.fa-space-shuttle:before {
  content: "\f197";
}
.fa-slack:before {
  content: "\f198";
}
.fa-envelope-square:before {
  content: "\f199";
}
.fa-wordpress:before {
  content: "\f19a";
}
.fa-openid:before {
  content: "\f19b";
}
.fa-institution:before,
.fa-bank:before,
.fa-university:before {
  content: "\f19c";
}
.fa-mortar-board:before,
.fa-graduation-cap:before {
  content: "\f19d";
}
.fa-yahoo:before {
  content: "\f19e";
}
.fa-google:before {
  content: "\f1a0";
}
.fa-reddit:before {
  content: "\f1a1";
}
.fa-reddit-square:before {
  content: "\f1a2";
}
.fa-stumbleupon-circle:before {
  content: "\f1a3";
}
.fa-stumbleupon:before {
  content: "\f1a4";
}
.fa-delicious:before {
  content: "\f1a5";
}
.fa-digg:before {
  content: "\f1a6";
}
.fa-pied-piper:before {
  content: "\f1a7";
}
.fa-pied-piper-alt:before {
  content: "\f1a8";
}
.fa-drupal:before {
  content: "\f1a9";
}
.fa-joomla:before {
  content: "\f1aa";
}
.fa-language:before {
  content: "\f1ab";
}
.fa-fax:before {
  content: "\f1ac";
}
.fa-building:before {
  content: "\f1ad";
}
.fa-child:before {
  content: "\f1ae";
}
.fa-paw:before {
  content: "\f1b0";
}
.fa-spoon:before {
  content: "\f1b1";
}
.fa-cube:before {
  content: "\f1b2";
}
.fa-cubes:before {
  content: "\f1b3";
}
.fa-behance:before {
  content: "\f1b4";
}
.fa-behance-square:before {
  content: "\f1b5";
}
.fa-steam:before {
  content: "\f1b6";
}
.fa-steam-square:before {
  content: "\f1b7";
}
.fa-recycle:before {
  content: "\f1b8";
}
.fa-automobile:before,
.fa-car:before {
  content: "\f1b9";
}
.fa-cab:before,
.fa-taxi:before {
  content: "\f1ba";
}
.fa-tree:before {
  content: "\f1bb";
}
.fa-spotify:before {
  content: "\f1bc";
}
.fa-deviantart:before {
  content: "\f1bd";
}
.fa-soundcloud:before {
  content: "\f1be";
}
.fa-database:before {
  content: "\f1c0";
}
.fa-file-pdf-o:before {
  content: "\f1c1";
}
.fa-file-word-o:before {
  content: "\f1c2";
}
.fa-file-excel-o:before {
  content: "\f1c3";
}
.fa-file-powerpoint-o:before {
  content: "\f1c4";
}
.fa-file-photo-o:before,
.fa-file-picture-o:before,
.fa-file-image-o:before {
  content: "\f1c5";
}
.fa-file-zip-o:before,
.fa-file-archive-o:before {
  content: "\f1c6";
}
.fa-file-sound-o:before,
.fa-file-audio-o:before {
  content: "\f1c7";
}
.fa-file-movie-o:before,
.fa-file-video-o:before {
  content: "\f1c8";
}
.fa-file-code-o:before {
  content: "\f1c9";
}
.fa-vine:before {
  content: "\f1ca";
}
.fa-codepen:before {
  content: "\f1cb";
}
.fa-jsfiddle:before {
  content: "\f1cc";
}
.fa-life-bouy:before,
.fa-life-buoy:before,
.fa-life-saver:before,
.fa-support:before,
.fa-life-ring:before {
  content: "\f1cd";
}
.fa-circle-o-notch:before {
  content: "\f1ce";
}
.fa-ra:before,
.fa-rebel:before {
  content: "\f1d0";
}
.fa-ge:before,
.fa-empire:before {
  content: "\f1d1";
}
.fa-git-square:before {
  content: "\f1d2";
}
.fa-git:before {
  content: "\f1d3";
}
.fa-hacker-news:before {
  content: "\f1d4";
}
.fa-tencent-weibo:before {
  content: "\f1d5";
}
.fa-qq:before {
  content: "\f1d6";
}
.fa-wechat:before,
.fa-weixin:before {
  content: "\f1d7";
}
.fa-send:before,
.fa-paper-plane:before {
  content: "\f1d8";
}
.fa-send-o:before,
.fa-paper-plane-o:before {
  content: "\f1d9";
}
.fa-history:before {
  content: "\f1da";
}
.fa-circle-thin:before {
  content: "\f1db";
}
.fa-header:before {
  content: "\f1dc";
}
.fa-paragraph:before {
  content: "\f1dd";
}
.fa-sliders:before {
  content: "\f1de";
}
.fa-share-alt:before {
  content: "\f1e0";
}
.fa-share-alt-square:before {
  content: "\f1e1";
}
.fa-bomb:before {
  content: "\f1e2";
}
.fa-soccer-ball-o:before,
.fa-futbol-o:before {
  content: "\f1e3";
}
.fa-tty:before {
  content: "\f1e4";
}
.fa-binoculars:before {
  content: "\f1e5";
}
.fa-plug:before {
  content: "\f1e6";
}
.fa-slideshare:before {
  content: "\f1e7";
}
.fa-twitch:before {
  content: "\f1e8";
}
.fa-yelp:before {
  content: "\f1e9";
}
.fa-newspaper-o:before {
  content: "\f1ea";
}
.fa-wifi:before {
  content: "\f1eb";
}
.fa-calculator:before {
  content: "\f1ec";
}
.fa-paypal:before {
  content: "\f1ed";
}
.fa-google-wallet:before {
  content: "\f1ee";
}
.fa-cc-visa:before {
  content: "\f1f0";
}
.fa-cc-mastercard:before {
  content: "\f1f1";
}
.fa-cc-discover:before {
  content: "\f1f2";
}
.fa-cc-amex:before {
  content: "\f1f3";
}
.fa-cc-paypal:before {
  content: "\f1f4";
}
.fa-cc-stripe:before {
  content: "\f1f5";
}
.fa-bell-slash:before {
  content: "\f1f6";
}
.fa-bell-slash-o:before {
  content: "\f1f7";
}
.fa-trash:before {
  content: "\f1f8";
}
.fa-copyright:before {
  content: "\f1f9";
}
.fa-at:before {
  content: "\f1fa";
}
.fa-eyedropper:before {
  content: "\f1fb";
}
.fa-paint-brush:before {
  content: "\f1fc";
}
.fa-birthday-cake:before {
  content: "\f1fd";
}
.fa-area-chart:before {
  content: "\f1fe";
}
.fa-pie-chart:before {
  content: "\f200";
}
.fa-line-chart:before {
  content: "\f201";
}
.fa-lastfm:before {
  content: "\f202";
}
.fa-lastfm-square:before {
  content: "\f203";
}
.fa-toggle-off:before {
  content: "\f204";
}
.fa-toggle-on:before {
  content: "\f205";
}
.fa-bicycle:before {
  content: "\f206";
}
.fa-bus:before {
  content: "\f207";
}
.fa-ioxhost:before {
  content: "\f208";
}
.fa-angellist:before {
  content: "\f209";
}
.fa-cc:before {
  content: "\f20a";
}
.fa-shekel:before,
.fa-sheqel:before,
.fa-ils:before {
  content: "\f20b";
}
.fa-meanpath:before {
  content: "\f20c";
}
/*!
*
* IPython base
*
*/
.modal.fade .modal-dialog {
  -webkit-transform: translate(0, 0);
  -ms-transform: translate(0, 0);
  -o-transform: translate(0, 0);
  transform: translate(0, 0);
}
code {
  color: #000;
}
pre {
  font-size: inherit;
  line-height: inherit;
}
label {
  font-weight: normal;
}
/* Make the page background atleast 100% the height of the view port */
/* Make the page itself atleast 70% the height of the view port */
.border-box-sizing {
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
}
.corner-all {
  border-radius: 2px;
}
.no-padding {
  padding: 0px;
}
/* Flexible box model classes */
/* Taken from Alex Russell http://infrequently.org/2009/08/css-3-progress/ */
/* This file is a compatability layer.  It allows the usage of flexible box 
model layouts accross multiple browsers, including older browsers.  The newest,
universal implementation of the flexible box model is used when available (see
`Modern browsers` comments below).  Browsers that are known to implement this 
new spec completely include:

    Firefox 28.0+
    Chrome 29.0+
    Internet Explorer 11+ 
    Opera 17.0+

Browsers not listed, including Safari, are supported via the styling under the
`Old browsers` comments below.
*/
.hbox {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
.hbox > * {
  /* Old browsers */
  -webkit-box-flex: 0;
  -moz-box-flex: 0;
  box-flex: 0;
  /* Modern browsers */
  flex: none;
}
.vbox {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
}
.vbox > * {
  /* Old browsers */
  -webkit-box-flex: 0;
  -moz-box-flex: 0;
  box-flex: 0;
  /* Modern browsers */
  flex: none;
}
.hbox.reverse,
.vbox.reverse,
.reverse {
  /* Old browsers */
  -webkit-box-direction: reverse;
  -moz-box-direction: reverse;
  box-direction: reverse;
  /* Modern browsers */
  flex-direction: row-reverse;
}
.hbox.box-flex0,
.vbox.box-flex0,
.box-flex0 {
  /* Old browsers */
  -webkit-box-flex: 0;
  -moz-box-flex: 0;
  box-flex: 0;
  /* Modern browsers */
  flex: none;
  width: auto;
}
.hbox.box-flex1,
.vbox.box-flex1,
.box-flex1 {
  /* Old browsers */
  -webkit-box-flex: 1;
  -moz-box-flex: 1;
  box-flex: 1;
  /* Modern browsers */
  flex: 1;
}
.hbox.box-flex,
.vbox.box-flex,
.box-flex {
  /* Old browsers */
  /* Old browsers */
  -webkit-box-flex: 1;
  -moz-box-flex: 1;
  box-flex: 1;
  /* Modern browsers */
  flex: 1;
}
.hbox.box-flex2,
.vbox.box-flex2,
.box-flex2 {
  /* Old browsers */
  -webkit-box-flex: 2;
  -moz-box-flex: 2;
  box-flex: 2;
  /* Modern browsers */
  flex: 2;
}
.box-group1 {
  /*  Deprecated */
  -webkit-box-flex-group: 1;
  -moz-box-flex-group: 1;
  box-flex-group: 1;
}
.box-group2 {
  /* Deprecated */
  -webkit-box-flex-group: 2;
  -moz-box-flex-group: 2;
  box-flex-group: 2;
}
.hbox.start,
.vbox.start,
.start {
  /* Old browsers */
  -webkit-box-pack: start;
  -moz-box-pack: start;
  box-pack: start;
  /* Modern browsers */
  justify-content: flex-start;
}
.hbox.end,
.vbox.end,
.end {
  /* Old browsers */
  -webkit-box-pack: end;
  -moz-box-pack: end;
  box-pack: end;
  /* Modern browsers */
  justify-content: flex-end;
}
.hbox.center,
.vbox.center,
.center {
  /* Old browsers */
  -webkit-box-pack: center;
  -moz-box-pack: center;
  box-pack: center;
  /* Modern browsers */
  justify-content: center;
}
.hbox.baseline,
.vbox.baseline,
.baseline {
  /* Old browsers */
  -webkit-box-pack: baseline;
  -moz-box-pack: baseline;
  box-pack: baseline;
  /* Modern browsers */
  justify-content: baseline;
}
.hbox.stretch,
.vbox.stretch,
.stretch {
  /* Old browsers */
  -webkit-box-pack: stretch;
  -moz-box-pack: stretch;
  box-pack: stretch;
  /* Modern browsers */
  justify-content: stretch;
}
.hbox.align-start,
.vbox.align-start,
.align-start {
  /* Old browsers */
  -webkit-box-align: start;
  -moz-box-align: start;
  box-align: start;
  /* Modern browsers */
  align-items: flex-start;
}
.hbox.align-end,
.vbox.align-end,
.align-end {
  /* Old browsers */
  -webkit-box-align: end;
  -moz-box-align: end;
  box-align: end;
  /* Modern browsers */
  align-items: flex-end;
}
.hbox.align-center,
.vbox.align-center,
.align-center {
  /* Old browsers */
  -webkit-box-align: center;
  -moz-box-align: center;
  box-align: center;
  /* Modern browsers */
  align-items: center;
}
.hbox.align-baseline,
.vbox.align-baseline,
.align-baseline {
  /* Old browsers */
  -webkit-box-align: baseline;
  -moz-box-align: baseline;
  box-align: baseline;
  /* Modern browsers */
  align-items: baseline;
}
.hbox.align-stretch,
.vbox.align-stretch,
.align-stretch {
  /* Old browsers */
  -webkit-box-align: stretch;
  -moz-box-align: stretch;
  box-align: stretch;
  /* Modern browsers */
  align-items: stretch;
}
div.error {
  margin: 2em;
  text-align: center;
}
div.error > h1 {
  font-size: 500%;
  line-height: normal;
}
div.error > p {
  font-size: 200%;
  line-height: normal;
}
div.traceback-wrapper {
  text-align: left;
  max-width: 800px;
  margin: auto;
}
/**
 * Primary styles
 *
 * Author: Jupyter Development Team
 */
body {
  background-color: #fff;
  /* This makes sure that the body covers the entire window and needs to
       be in a different element than the display: box in wrapper below */
  position: absolute;
  left: 0px;
  right: 0px;
  top: 0px;
  bottom: 0px;
  overflow: visible;
}
body > #header {
  /* Initially hidden to prevent FLOUC */
  display: none;
  background-color: #fff;
  /* Display over codemirror */
  position: relative;
  z-index: 100;
}
body > #header #header-container {
  padding-bottom: 5px;
  padding-top: 5px;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
}
body > #header .header-bar {
  width: 100%;
  height: 1px;
  background: #e7e7e7;
  margin-bottom: -1px;
}
@media print {
  body > #header {
    display: none !important;
  }
}
#header-spacer {
  width: 100%;
  visibility: hidden;
}
@media print {
  #header-spacer {
    display: none;
  }
}
#ipython_notebook {
  padding-left: 0px;
  padding-top: 1px;
  padding-bottom: 1px;
}
@media (max-width: 991px) {
  #ipython_notebook {
    margin-left: 10px;
  }
}
[dir="rtl"] #ipython_notebook {
  float: right !important;
}
#noscript {
  width: auto;
  padding-top: 16px;
  padding-bottom: 16px;
  text-align: center;
  font-size: 22px;
  color: red;
  font-weight: bold;
}
#ipython_notebook img {
  height: 28px;
}
#site {
  width: 100%;
  display: none;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  overflow: auto;
}
@media print {
  #site {
    height: auto !important;
  }
}
/* Smaller buttons */
.ui-button .ui-button-text {
  padding: 0.2em 0.8em;
  font-size: 77%;
}
input.ui-button {
  padding: 0.3em 0.9em;
}
span#login_widget {
  float: right;
}
span#login_widget > .button,
#logout {
  color: #333;
  background-color: #fff;
  border-color: #ccc;
}
span#login_widget > .button:focus,
#logout:focus,
span#login_widget > .button.focus,
#logout.focus {
  color: #333;
  background-color: #e6e6e6;
  border-color: #8c8c8c;
}
span#login_widget > .button:hover,
#logout:hover {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
span#login_widget > .button:active,
#logout:active,
span#login_widget > .button.active,
#logout.active,
.open > .dropdown-togglespan#login_widget > .button,
.open > .dropdown-toggle#logout {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
span#login_widget > .button:active:hover,
#logout:active:hover,
span#login_widget > .button.active:hover,
#logout.active:hover,
.open > .dropdown-togglespan#login_widget > .button:hover,
.open > .dropdown-toggle#logout:hover,
span#login_widget > .button:active:focus,
#logout:active:focus,
span#login_widget > .button.active:focus,
#logout.active:focus,
.open > .dropdown-togglespan#login_widget > .button:focus,
.open > .dropdown-toggle#logout:focus,
span#login_widget > .button:active.focus,
#logout:active.focus,
span#login_widget > .button.active.focus,
#logout.active.focus,
.open > .dropdown-togglespan#login_widget > .button.focus,
.open > .dropdown-toggle#logout.focus {
  color: #333;
  background-color: #d4d4d4;
  border-color: #8c8c8c;
}
span#login_widget > .button:active,
#logout:active,
span#login_widget > .button.active,
#logout.active,
.open > .dropdown-togglespan#login_widget > .button,
.open > .dropdown-toggle#logout {
  background-image: none;
}
span#login_widget > .button.disabled:hover,
#logout.disabled:hover,
span#login_widget > .button[disabled]:hover,
#logout[disabled]:hover,
fieldset[disabled] span#login_widget > .button:hover,
fieldset[disabled] #logout:hover,
span#login_widget > .button.disabled:focus,
#logout.disabled:focus,
span#login_widget > .button[disabled]:focus,
#logout[disabled]:focus,
fieldset[disabled] span#login_widget > .button:focus,
fieldset[disabled] #logout:focus,
span#login_widget > .button.disabled.focus,
#logout.disabled.focus,
span#login_widget > .button[disabled].focus,
#logout[disabled].focus,
fieldset[disabled] span#login_widget > .button.focus,
fieldset[disabled] #logout.focus {
  background-color: #fff;
  border-color: #ccc;
}
span#login_widget > .button .badge,
#logout .badge {
  color: #fff;
  background-color: #333;
}
.nav-header {
  text-transform: none;
}
#header > span {
  margin-top: 10px;
}
.modal_stretch .modal-dialog {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
  min-height: 80vh;
}
.modal_stretch .modal-dialog .modal-body {
  max-height: calc(100vh - 200px);
  overflow: auto;
  flex: 1;
}
@media (min-width: 768px) {
  .modal .modal-dialog {
    width: 700px;
  }
}
@media (min-width: 768px) {
  select.form-control {
    margin-left: 12px;
    margin-right: 12px;
  }
}
/*!
*
* IPython auth
*
*/
.center-nav {
  display: inline-block;
  margin-bottom: -4px;
}
/*!
*
* IPython tree view
*
*/
/* We need an invisible input field on top of the sentense*/
/* "Drag file onto the list ..." */
.alternate_upload {
  background-color: none;
  display: inline;
}
.alternate_upload.form {
  padding: 0;
  margin: 0;
}
.alternate_upload input.fileinput {
  text-align: center;
  vertical-align: middle;
  display: inline;
  opacity: 0;
  z-index: 2;
  width: 12ex;
  margin-right: -12ex;
}
.alternate_upload .btn-upload {
  height: 22px;
}
/**
 * Primary styles
 *
 * Author: Jupyter Development Team
 */
[dir="rtl"] #tabs li {
  float: right;
}
ul#tabs {
  margin-bottom: 4px;
}
[dir="rtl"] ul#tabs {
  margin-right: 0px;
}
ul#tabs a {
  padding-top: 6px;
  padding-bottom: 4px;
}
ul.breadcrumb a:focus,
ul.breadcrumb a:hover {
  text-decoration: none;
}
ul.breadcrumb i.icon-home {
  font-size: 16px;
  margin-right: 4px;
}
ul.breadcrumb span {
  color: #5e5e5e;
}
.list_toolbar {
  padding: 4px 0 4px 0;
  vertical-align: middle;
}
.list_toolbar .tree-buttons {
  padding-top: 1px;
}
[dir="rtl"] .list_toolbar .tree-buttons {
  float: left !important;
}
[dir="rtl"] .list_toolbar .pull-right {
  padding-top: 1px;
  float: left !important;
}
[dir="rtl"] .list_toolbar .pull-left {
  float: right !important;
}
.dynamic-buttons {
  padding-top: 3px;
  display: inline-block;
}
.list_toolbar [class*="span"] {
  min-height: 24px;
}
.list_header {
  font-weight: bold;
  background-color: #EEE;
}
.list_placeholder {
  font-weight: bold;
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 7px;
  padding-right: 7px;
}
.list_container {
  margin-top: 4px;
  margin-bottom: 20px;
  border: 1px solid #ddd;
  border-radius: 2px;
}
.list_container > div {
  border-bottom: 1px solid #ddd;
}
.list_container > div:hover .list-item {
  background-color: red;
}
.list_container > div:last-child {
  border: none;
}
.list_item:hover .list_item {
  background-color: #ddd;
}
.list_item a {
  text-decoration: none;
}
.list_item:hover {
  background-color: #fafafa;
}
.list_header > div,
.list_item > div {
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 7px;
  padding-right: 7px;
  line-height: 22px;
}
.list_header > div input,
.list_item > div input {
  margin-right: 7px;
  margin-left: 14px;
  vertical-align: baseline;
  line-height: 22px;
  position: relative;
  top: -1px;
}
.list_header > div .item_link,
.list_item > div .item_link {
  margin-left: -1px;
  vertical-align: baseline;
  line-height: 22px;
}
.new-file input[type=checkbox] {
  visibility: hidden;
}
.item_name {
  line-height: 22px;
  height: 24px;
}
.item_icon {
  font-size: 14px;
  color: #5e5e5e;
  margin-right: 7px;
  margin-left: 7px;
  line-height: 22px;
  vertical-align: baseline;
}
.item_buttons {
  line-height: 1em;
  margin-left: -5px;
}
.item_buttons .btn,
.item_buttons .btn-group,
.item_buttons .input-group {
  float: left;
}
.item_buttons > .btn,
.item_buttons > .btn-group,
.item_buttons > .input-group {
  margin-left: 5px;
}
.item_buttons .btn {
  min-width: 13ex;
}
.item_buttons .running-indicator {
  padding-top: 4px;
  color: #5cb85c;
}
.item_buttons .kernel-name {
  padding-top: 4px;
  color: #5bc0de;
  margin-right: 7px;
  float: left;
}
.toolbar_info {
  height: 24px;
  line-height: 24px;
}
.list_item input:not([type=checkbox]) {
  padding-top: 3px;
  padding-bottom: 3px;
  height: 22px;
  line-height: 14px;
  margin: 0px;
}
.highlight_text {
  color: blue;
}
#project_name {
  display: inline-block;
  padding-left: 7px;
  margin-left: -2px;
}
#project_name > .breadcrumb {
  padding: 0px;
  margin-bottom: 0px;
  background-color: transparent;
  font-weight: bold;
}
#tree-selector {
  padding-right: 0px;
}
[dir="rtl"] #tree-selector a {
  float: right;
}
#button-select-all {
  min-width: 50px;
}
#select-all {
  margin-left: 7px;
  margin-right: 2px;
}
.menu_icon {
  margin-right: 2px;
}
.tab-content .row {
  margin-left: 0px;
  margin-right: 0px;
}
.folder_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f114";
}
.folder_icon:before.pull-left {
  margin-right: .3em;
}
.folder_icon:before.pull-right {
  margin-left: .3em;
}
.notebook_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f02d";
  position: relative;
  top: -1px;
}
.notebook_icon:before.pull-left {
  margin-right: .3em;
}
.notebook_icon:before.pull-right {
  margin-left: .3em;
}
.running_notebook_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f02d";
  position: relative;
  top: -1px;
  color: #5cb85c;
}
.running_notebook_icon:before.pull-left {
  margin-right: .3em;
}
.running_notebook_icon:before.pull-right {
  margin-left: .3em;
}
.file_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f016";
  position: relative;
  top: -2px;
}
.file_icon:before.pull-left {
  margin-right: .3em;
}
.file_icon:before.pull-right {
  margin-left: .3em;
}
#notebook_toolbar .pull-right {
  padding-top: 0px;
  margin-right: -1px;
}
ul#new-menu {
  left: auto;
  right: 0;
}
[dir="rtl"] #new-menu {
  text-align: right;
}
.kernel-menu-icon {
  padding-right: 12px;
  width: 24px;
  content: "\f096";
}
.kernel-menu-icon:before {
  content: "\f096";
}
.kernel-menu-icon-current:before {
  content: "\f00c";
}
#tab_content {
  padding-top: 20px;
}
#running .panel-group .panel {
  margin-top: 3px;
  margin-bottom: 1em;
}
#running .panel-group .panel .panel-heading {
  background-color: #EEE;
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 7px;
  padding-right: 7px;
  line-height: 22px;
}
#running .panel-group .panel .panel-heading a:focus,
#running .panel-group .panel .panel-heading a:hover {
  text-decoration: none;
}
#running .panel-group .panel .panel-body {
  padding: 0px;
}
#running .panel-group .panel .panel-body .list_container {
  margin-top: 0px;
  margin-bottom: 0px;
  border: 0px;
  border-radius: 0px;
}
#running .panel-group .panel .panel-body .list_container .list_item {
  border-bottom: 1px solid #ddd;
}
#running .panel-group .panel .panel-body .list_container .list_item:last-child {
  border-bottom: 0px;
}
[dir="rtl"] #running .col-sm-8 {
  float: right !important;
}
.delete-button {
  display: none;
}
.duplicate-button {
  display: none;
}
.rename-button {
  display: none;
}
.shutdown-button {
  display: none;
}
.dynamic-instructions {
  display: inline-block;
  padding-top: 4px;
}
/*!
*
* IPython text editor webapp
*
*/
.selected-keymap i.fa {
  padding: 0px 5px;
}
.selected-keymap i.fa:before {
  content: "\f00c";
}
#mode-menu {
  overflow: auto;
  max-height: 20em;
}
.edit_app #header {
  -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
}
.edit_app #menubar .navbar {
  /* Use a negative 1 bottom margin, so the border overlaps the border of the
    header */
  margin-bottom: -1px;
}
.dirty-indicator {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  width: 20px;
}
.dirty-indicator.pull-left {
  margin-right: .3em;
}
.dirty-indicator.pull-right {
  margin-left: .3em;
}
.dirty-indicator-dirty {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  width: 20px;
}
.dirty-indicator-dirty.pull-left {
  margin-right: .3em;
}
.dirty-indicator-dirty.pull-right {
  margin-left: .3em;
}
.dirty-indicator-clean {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  width: 20px;
}
.dirty-indicator-clean.pull-left {
  margin-right: .3em;
}
.dirty-indicator-clean.pull-right {
  margin-left: .3em;
}
.dirty-indicator-clean:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f00c";
}
.dirty-indicator-clean:before.pull-left {
  margin-right: .3em;
}
.dirty-indicator-clean:before.pull-right {
  margin-left: .3em;
}
#filename {
  font-size: 16pt;
  display: table;
  padding: 0px 5px;
}
#current-mode {
  padding-left: 5px;
  padding-right: 5px;
}
#texteditor-backdrop {
  padding-top: 20px;
  padding-bottom: 20px;
}
@media not print {
  #texteditor-backdrop {
    background-color: #EEE;
  }
}
@media print {
  #texteditor-backdrop #texteditor-container .CodeMirror-gutter,
  #texteditor-backdrop #texteditor-container .CodeMirror-gutters {
    background-color: #fff;
  }
}
@media not print {
  #texteditor-backdrop #texteditor-container .CodeMirror-gutter,
  #texteditor-backdrop #texteditor-container .CodeMirror-gutters {
    background-color: #fff;
  }
}
@media not print {
  #texteditor-backdrop #texteditor-container {
    padding: 0px;
    background-color: #fff;
    -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
    box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  }
}
/*!
*
* IPython notebook
*
*/
/* CSS font colors for translated ANSI colors. */
.ansibold {
  font-weight: bold;
}
/* use dark versions for foreground, to improve visibility */
.ansiblack {
  color: black;
}
.ansired {
  color: darkred;
}
.ansigreen {
  color: darkgreen;
}
.ansiyellow {
  color: #c4a000;
}
.ansiblue {
  color: darkblue;
}
.ansipurple {
  color: darkviolet;
}
.ansicyan {
  color: steelblue;
}
.ansigray {
  color: gray;
}
/* and light for background, for the same reason */
.ansibgblack {
  background-color: black;
}
.ansibgred {
  background-color: red;
}
.ansibggreen {
  background-color: green;
}
.ansibgyellow {
  background-color: yellow;
}
.ansibgblue {
  background-color: blue;
}
.ansibgpurple {
  background-color: magenta;
}
.ansibgcyan {
  background-color: cyan;
}
.ansibggray {
  background-color: gray;
}
div.cell {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
  border-radius: 2px;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  border-width: 1px;
  border-style: solid;
  border-color: transparent;
  width: 100%;
  padding: 5px;
  /* This acts as a spacer between cells, that is outside the border */
  margin: 0px;
  outline: none;
  border-left-width: 1px;
  padding-left: 5px;
  background: linear-gradient(to right, transparent -40px, transparent 1px, transparent 1px, transparent 100%);
}
div.cell.jupyter-soft-selected {
  border-left-color: #90CAF9;
  border-left-color: #E3F2FD;
  border-left-width: 1px;
  padding-left: 5px;
  border-right-color: #E3F2FD;
  border-right-width: 1px;
  background: #E3F2FD;
}
@media print {
  div.cell.jupyter-soft-selected {
    border-color: transparent;
  }
}
div.cell.selected {
  border-color: #ababab;
  border-left-width: 0px;
  padding-left: 6px;
  background: linear-gradient(to right, #42A5F5 -40px, #42A5F5 5px, transparent 5px, transparent 100%);
}
@media print {
  div.cell.selected {
    border-color: transparent;
  }
}
div.cell.selected.jupyter-soft-selected {
  border-left-width: 0;
  padding-left: 6px;
  background: linear-gradient(to right, #42A5F5 -40px, #42A5F5 7px, #E3F2FD 7px, #E3F2FD 100%);
}
.edit_mode div.cell.selected {
  border-color: #66BB6A;
  border-left-width: 0px;
  padding-left: 6px;
  background: linear-gradient(to right, #66BB6A -40px, #66BB6A 5px, transparent 5px, transparent 100%);
}
@media print {
  .edit_mode div.cell.selected {
    border-color: transparent;
  }
}
.prompt {
  /* This needs to be wide enough for 3 digit prompt numbers: In[100]: */
  min-width: 14ex;
  /* This padding is tuned to match the padding on the CodeMirror editor. */
  padding: 0.4em;
  margin: 0px;
  font-family: monospace;
  text-align: right;
  /* This has to match that of the the CodeMirror class line-height below */
  line-height: 1.21429em;
  /* Don't highlight prompt number selection */
  -webkit-touch-callout: none;
  -webkit-user-select: none;
  -khtml-user-select: none;
  -moz-user-select: none;
  -ms-user-select: none;
  user-select: none;
  /* Use default cursor */
  cursor: default;
}
@media (max-width: 540px) {
  .prompt {
    text-align: left;
  }
}
div.inner_cell {
  min-width: 0;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
  /* Old browsers */
  -webkit-box-flex: 1;
  -moz-box-flex: 1;
  box-flex: 1;
  /* Modern browsers */
  flex: 1;
}
/* input_area and input_prompt must match in top border and margin for alignment */
div.input_area {
  border: 1px solid #cfcfcf;
  border-radius: 2px;
  background: #f7f7f7;
  line-height: 1.21429em;
}
/* This is needed so that empty prompt areas can collapse to zero height when there
   is no content in the output_subarea and the prompt. The main purpose of this is
   to make sure that empty JavaScript output_subareas have no height. */
div.prompt:empty {
  padding-top: 0;
  padding-bottom: 0;
}
div.unrecognized_cell {
  padding: 5px 5px 5px 0px;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
div.unrecognized_cell .inner_cell {
  border-radius: 2px;
  padding: 5px;
  font-weight: bold;
  color: red;
  border: 1px solid #cfcfcf;
  background: #eaeaea;
}
div.unrecognized_cell .inner_cell a {
  color: inherit;
  text-decoration: none;
}
div.unrecognized_cell .inner_cell a:hover {
  color: inherit;
  text-decoration: none;
}
@media (max-width: 540px) {
  div.unrecognized_cell > div.prompt {
    display: none;
  }
}
div.code_cell {
  /* avoid page breaking on code cells when printing */
}
@media print {
  div.code_cell {
    page-break-inside: avoid;
  }
}
/* any special styling for code cells that are currently running goes here */
div.input {
  page-break-inside: avoid;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
@media (max-width: 540px) {
  div.input {
    /* Old browsers */
    display: -webkit-box;
    -webkit-box-orient: vertical;
    -webkit-box-align: stretch;
    display: -moz-box;
    -moz-box-orient: vertical;
    -moz-box-align: stretch;
    display: box;
    box-orient: vertical;
    box-align: stretch;
    /* Modern browsers */
    display: flex;
    flex-direction: column;
    align-items: stretch;
  }
}
/* input_area and input_prompt must match in top border and margin for alignment */
div.input_prompt {
  color: #303F9F;
  border-top: 1px solid transparent;
}
div.input_area > div.highlight {
  margin: 0.4em;
  border: none;
  padding: 0px;
  background-color: transparent;
}
div.input_area > div.highlight > pre {
  margin: 0px;
  border: none;
  padding: 0px;
  background-color: transparent;
}
/* The following gets added to the <head> if it is detected that the user has a
 * monospace font with inconsistent normal/bold/italic height.  See
 * notebookmain.js.  Such fonts will have keywords vertically offset with
 * respect to the rest of the text.  The user should select a better font.
 * See: https://github.com/ipython/ipython/issues/1503
 *
 * .CodeMirror span {
 *      vertical-align: bottom;
 * }
 */
.CodeMirror {
  line-height: 1.21429em;
  /* Changed from 1em to our global default */
  font-size: 14px;
  height: auto;
  /* Changed to auto to autogrow */
  background: none;
  /* Changed from white to allow our bg to show through */
}
.CodeMirror-scroll {
  /*  The CodeMirror docs are a bit fuzzy on if overflow-y should be hidden or visible.*/
  /*  We have found that if it is visible, vertical scrollbars appear with font size changes.*/
  overflow-y: hidden;
  overflow-x: auto;
}
.CodeMirror-lines {
  /* In CM2, this used to be 0.4em, but in CM3 it went to 4px. We need the em value because */
  /* we have set a different line-height and want this to scale with that. */
  padding: 0.4em;
}
.CodeMirror-linenumber {
  padding: 0 8px 0 4px;
}
.CodeMirror-gutters {
  border-bottom-left-radius: 2px;
  border-top-left-radius: 2px;
}
.CodeMirror pre {
  /* In CM3 this went to 4px from 0 in CM2. We need the 0 value because of how we size */
  /* .CodeMirror-lines */
  padding: 0;
  border: 0;
  border-radius: 0;
}
/*

Original style from softwaremaniacs.org (c) Ivan Sagalaev <Maniac@SoftwareManiacs.Org>
Adapted from GitHub theme

*/
.highlight-base {
  color: #000;
}
.highlight-variable {
  color: #000;
}
.highlight-variable-2 {
  color: #1a1a1a;
}
.highlight-variable-3 {
  color: #333333;
}
.highlight-string {
  color: #BA2121;
}
.highlight-comment {
  color: #408080;
  font-style: italic;
}
.highlight-number {
  color: #080;
}
.highlight-atom {
  color: #88F;
}
.highlight-keyword {
  color: #008000;
  font-weight: bold;
}
.highlight-builtin {
  color: #008000;
}
.highlight-error {
  color: #f00;
}
.highlight-operator {
  color: #AA22FF;
  font-weight: bold;
}
.highlight-meta {
  color: #AA22FF;
}
/* previously not defined, copying from default codemirror */
.highlight-def {
  color: #00f;
}
.highlight-string-2 {
  color: #f50;
}
.highlight-qualifier {
  color: #555;
}
.highlight-bracket {
  color: #997;
}
.highlight-tag {
  color: #170;
}
.highlight-attribute {
  color: #00c;
}
.highlight-header {
  color: blue;
}
.highlight-quote {
  color: #090;
}
.highlight-link {
  color: #00c;
}
/* apply the same style to codemirror */
.cm-s-ipython span.cm-keyword {
  color: #008000;
  font-weight: bold;
}
.cm-s-ipython span.cm-atom {
  color: #88F;
}
.cm-s-ipython span.cm-number {
  color: #080;
}
.cm-s-ipython span.cm-def {
  color: #00f;
}
.cm-s-ipython span.cm-variable {
  color: #000;
}
.cm-s-ipython span.cm-operator {
  color: #AA22FF;
  font-weight: bold;
}
.cm-s-ipython span.cm-variable-2 {
  color: #1a1a1a;
}
.cm-s-ipython span.cm-variable-3 {
  color: #333333;
}
.cm-s-ipython span.cm-comment {
  color: #408080;
  font-style: italic;
}
.cm-s-ipython span.cm-string {
  color: #BA2121;
}
.cm-s-ipython span.cm-string-2 {
  color: #f50;
}
.cm-s-ipython span.cm-meta {
  color: #AA22FF;
}
.cm-s-ipython span.cm-qualifier {
  color: #555;
}
.cm-s-ipython span.cm-builtin {
  color: #008000;
}
.cm-s-ipython span.cm-bracket {
  color: #997;
}
.cm-s-ipython span.cm-tag {
  color: #170;
}
.cm-s-ipython span.cm-attribute {
  color: #00c;
}
.cm-s-ipython span.cm-header {
  color: blue;
}
.cm-s-ipython span.cm-quote {
  color: #090;
}
.cm-s-ipython span.cm-link {
  color: #00c;
}
.cm-s-ipython span.cm-error {
  color: #f00;
}
.cm-s-ipython span.cm-tab {
  background: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAADAAAAAMCAYAAAAkuj5RAAAAAXNSR0IArs4c6QAAAGFJREFUSMft1LsRQFAQheHPowAKoACx3IgEKtaEHujDjORSgWTH/ZOdnZOcM/sgk/kFFWY0qV8foQwS4MKBCS3qR6ixBJvElOobYAtivseIE120FaowJPN75GMu8j/LfMwNjh4HUpwg4LUAAAAASUVORK5CYII=);
  background-position: right;
  background-repeat: no-repeat;
}
div.output_wrapper {
  /* this position must be relative to enable descendents to be absolute within it */
  position: relative;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
  z-index: 1;
}
/* class for the output area when it should be height-limited */
div.output_scroll {
  /* ideally, this would be max-height, but FF barfs all over that */
  height: 24em;
  /* FF needs this *and the wrapper* to specify full width, or it will shrinkwrap */
  width: 100%;
  overflow: auto;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 2px 8px rgba(0, 0, 0, 0.8);
  box-shadow: inset 0 2px 8px rgba(0, 0, 0, 0.8);
  display: block;
}
/* output div while it is collapsed */
div.output_collapsed {
  margin: 0px;
  padding: 0px;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
}
div.out_prompt_overlay {
  height: 100%;
  padding: 0px 0.4em;
  position: absolute;
  border-radius: 2px;
}
div.out_prompt_overlay:hover {
  /* use inner shadow to get border that is computed the same on WebKit/FF */
  -webkit-box-shadow: inset 0 0 1px #000;
  box-shadow: inset 0 0 1px #000;
  background: rgba(240, 240, 240, 0.5);
}
div.output_prompt {
  color: #D84315;
}
/* This class is the outer container of all output sections. */
div.output_area {
  padding: 0px;
  page-break-inside: avoid;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
div.output_area .MathJax_Display {
  text-align: left !important;
}
div.output_area .rendered_html table {
  margin-left: 0;
  margin-right: 0;
}
div.output_area .rendered_html img {
  margin-left: 0;
  margin-right: 0;
}
div.output_area img,
div.output_area svg {
  max-width: 100%;
  height: auto;
}
div.output_area img.unconfined,
div.output_area svg.unconfined {
  max-width: none;
}
/* This is needed to protect the pre formating from global settings such
   as that of bootstrap */
.output {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
}
@media (max-width: 540px) {
  div.output_area {
    /* Old browsers */
    display: -webkit-box;
    -webkit-box-orient: vertical;
    -webkit-box-align: stretch;
    display: -moz-box;
    -moz-box-orient: vertical;
    -moz-box-align: stretch;
    display: box;
    box-orient: vertical;
    box-align: stretch;
    /* Modern browsers */
    display: flex;
    flex-direction: column;
    align-items: stretch;
  }
}
div.output_area pre {
  margin: 0;
  padding: 0;
  border: 0;
  vertical-align: baseline;
  color: black;
  background-color: transparent;
  border-radius: 0;
}
/* This class is for the output subarea inside the output_area and after
   the prompt div. */
div.output_subarea {
  overflow-x: auto;
  padding: 0.4em;
  /* Old browsers */
  -webkit-box-flex: 1;
  -moz-box-flex: 1;
  box-flex: 1;
  /* Modern browsers */
  flex: 1;
  max-width: calc(100% - 14ex);
}
div.output_scroll div.output_subarea {
  overflow-x: visible;
}
/* The rest of the output_* classes are for special styling of the different
   output types */
/* all text output has this class: */
div.output_text {
  text-align: left;
  color: #000;
  /* This has to match that of the the CodeMirror class line-height below */
  line-height: 1.21429em;
}
/* stdout/stderr are 'text' as well as 'stream', but execute_result/error are *not* streams */
div.output_stderr {
  background: #fdd;
  /* very light red background for stderr */
}
div.output_latex {
  text-align: left;
}
/* Empty output_javascript divs should have no height */
div.output_javascript:empty {
  padding: 0;
}
.js-error {
  color: darkred;
}
/* raw_input styles */
div.raw_input_container {
  line-height: 1.21429em;
  padding-top: 5px;
}
pre.raw_input_prompt {
  /* nothing needed here. */
}
input.raw_input {
  font-family: monospace;
  font-size: inherit;
  color: inherit;
  width: auto;
  /* make sure input baseline aligns with prompt */
  vertical-align: baseline;
  /* padding + margin = 0.5em between prompt and cursor */
  padding: 0em 0.25em;
  margin: 0em 0.25em;
}
input.raw_input:focus {
  box-shadow: none;
}
p.p-space {
  margin-bottom: 10px;
}
div.output_unrecognized {
  padding: 5px;
  font-weight: bold;
  color: red;
}
div.output_unrecognized a {
  color: inherit;
  text-decoration: none;
}
div.output_unrecognized a:hover {
  color: inherit;
  text-decoration: none;
}
.rendered_html {
  color: #000;
  /* any extras will just be numbers: */
}
.rendered_html em {
  font-style: italic;
}
.rendered_html strong {
  font-weight: bold;
}
.rendered_html u {
  text-decoration: underline;
}
.rendered_html :link {
  text-decoration: underline;
}
.rendered_html :visited {
  text-decoration: underline;
}
.rendered_html h1 {
  font-size: 185.7%;
  margin: 1.08em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
}
.rendered_html h2 {
  font-size: 157.1%;
  margin: 1.27em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
}
.rendered_html h3 {
  font-size: 128.6%;
  margin: 1.55em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
}
.rendered_html h4 {
  font-size: 100%;
  margin: 2em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
}
.rendered_html h5 {
  font-size: 100%;
  margin: 2em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
  font-style: italic;
}
.rendered_html h6 {
  font-size: 100%;
  margin: 2em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
  font-style: italic;
}
.rendered_html h1:first-child {
  margin-top: 0.538em;
}
.rendered_html h2:first-child {
  margin-top: 0.636em;
}
.rendered_html h3:first-child {
  margin-top: 0.777em;
}
.rendered_html h4:first-child {
  margin-top: 1em;
}
.rendered_html h5:first-child {
  margin-top: 1em;
}
.rendered_html h6:first-child {
  margin-top: 1em;
}
.rendered_html ul {
  list-style: disc;
  margin: 0em 2em;
  padding-left: 0px;
}
.rendered_html ul ul {
  list-style: square;
  margin: 0em 2em;
}
.rendered_html ul ul ul {
  list-style: circle;
  margin: 0em 2em;
}
.rendered_html ol {
  list-style: decimal;
  margin: 0em 2em;
  padding-left: 0px;
}
.rendered_html ol ol {
  list-style: upper-alpha;
  margin: 0em 2em;
}
.rendered_html ol ol ol {
  list-style: lower-alpha;
  margin: 0em 2em;
}
.rendered_html ol ol ol ol {
  list-style: lower-roman;
  margin: 0em 2em;
}
.rendered_html ol ol ol ol ol {
  list-style: decimal;
  margin: 0em 2em;
}
.rendered_html * + ul {
  margin-top: 1em;
}
.rendered_html * + ol {
  margin-top: 1em;
}
.rendered_html hr {
  color: black;
  background-color: black;
}
.rendered_html pre {
  margin: 1em 2em;
}
.rendered_html pre,
.rendered_html code {
  border: 0;
  background-color: #fff;
  color: #000;
  font-size: 100%;
  padding: 0px;
}
.rendered_html blockquote {
  margin: 1em 2em;
}
.rendered_html table {
  margin-left: auto;
  margin-right: auto;
  border: 1px solid black;
  border-collapse: collapse;
}
.rendered_html tr,
.rendered_html th,
.rendered_html td {
  border: 1px solid black;
  border-collapse: collapse;
  margin: 1em 2em;
}
.rendered_html td,
.rendered_html th {
  text-align: left;
  vertical-align: middle;
  padding: 4px;
}
.rendered_html th {
  font-weight: bold;
}
.rendered_html * + table {
  margin-top: 1em;
}
.rendered_html p {
  text-align: left;
}
.rendered_html * + p {
  margin-top: 1em;
}
.rendered_html img {
  display: block;
  margin-left: auto;
  margin-right: auto;
}
.rendered_html * + img {
  margin-top: 1em;
}
.rendered_html img,
.rendered_html svg {
  max-width: 100%;
  height: auto;
}
.rendered_html img.unconfined,
.rendered_html svg.unconfined {
  max-width: none;
}
div.text_cell {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
@media (max-width: 540px) {
  div.text_cell > div.prompt {
    display: none;
  }
}
div.text_cell_render {
  /*font-family: "Helvetica Neue", Arial, Helvetica, Geneva, sans-serif;*/
  outline: none;
  resize: none;
  width: inherit;
  border-style: none;
  padding: 0.5em 0.5em 0.5em 0.4em;
  color: #000;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
}
a.anchor-link:link {
  text-decoration: none;
  padding: 0px 20px;
  visibility: hidden;
}
h1:hover .anchor-link,
h2:hover .anchor-link,
h3:hover .anchor-link,
h4:hover .anchor-link,
h5:hover .anchor-link,
h6:hover .anchor-link {
  visibility: visible;
}
.text_cell.rendered .input_area {
  display: none;
}
.text_cell.rendered .rendered_html {
  overflow-x: auto;
  overflow-y: hidden;
}
.text_cell.unrendered .text_cell_render {
  display: none;
}
.cm-header-1,
.cm-header-2,
.cm-header-3,
.cm-header-4,
.cm-header-5,
.cm-header-6 {
  font-weight: bold;
  font-family: "Helvetica Neue", Helvetica, Arial, sans-serif;
}
.cm-header-1 {
  font-size: 185.7%;
}
.cm-header-2 {
  font-size: 157.1%;
}
.cm-header-3 {
  font-size: 128.6%;
}
.cm-header-4 {
  font-size: 110%;
}
.cm-header-5 {
  font-size: 100%;
  font-style: italic;
}
.cm-header-6 {
  font-size: 100%;
  font-style: italic;
}
/*!
*
* IPython notebook webapp
*
*/
@media (max-width: 767px) {
  .notebook_app {
    padding-left: 0px;
    padding-right: 0px;
  }
}
#ipython-main-app {
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  height: 100%;
}
div#notebook_panel {
  margin: 0px;
  padding: 0px;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  height: 100%;
}
div#notebook {
  font-size: 14px;
  line-height: 20px;
  overflow-y: hidden;
  overflow-x: auto;
  width: 100%;
  /* This spaces the page away from the edge of the notebook area */
  padding-top: 20px;
  margin: 0px;
  outline: none;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  min-height: 100%;
}
@media not print {
  #notebook-container {
    padding: 15px;
    background-color: #fff;
    min-height: 0;
    -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
    box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  }
}
@media print {
  #notebook-container {
    width: 100%;
  }
}
div.ui-widget-content {
  border: 1px solid #ababab;
  outline: none;
}
pre.dialog {
  background-color: #f7f7f7;
  border: 1px solid #ddd;
  border-radius: 2px;
  padding: 0.4em;
  padding-left: 2em;
}
p.dialog {
  padding: 0.2em;
}
/* Word-wrap output correctly.  This is the CSS3 spelling, though Firefox seems
   to not honor it correctly.  Webkit browsers (Chrome, rekonq, Safari) do.
 */
pre,
code,
kbd,
samp {
  white-space: pre-wrap;
}
#fonttest {
  font-family: monospace;
}
p {
  margin-bottom: 0;
}
.end_space {
  min-height: 100px;
  transition: height .2s ease;
}
.notebook_app > #header {
  -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
}
@media not print {
  .notebook_app {
    background-color: #EEE;
  }
}
kbd {
  border-style: solid;
  border-width: 1px;
  box-shadow: none;
  margin: 2px;
  padding-left: 2px;
  padding-right: 2px;
  padding-top: 1px;
  padding-bottom: 1px;
}
/* CSS for the cell toolbar */
.celltoolbar {
  border: thin solid #CFCFCF;
  border-bottom: none;
  background: #EEE;
  border-radius: 2px 2px 0px 0px;
  width: 100%;
  height: 29px;
  padding-right: 4px;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
  /* Old browsers */
  -webkit-box-pack: end;
  -moz-box-pack: end;
  box-pack: end;
  /* Modern browsers */
  justify-content: flex-end;
  display: -webkit-flex;
}
@media print {
  .celltoolbar {
    display: none;
  }
}
.ctb_hideshow {
  display: none;
  vertical-align: bottom;
}
/* ctb_show is added to the ctb_hideshow div to show the cell toolbar.
   Cell toolbars are only shown when the ctb_global_show class is also set.
*/
.ctb_global_show .ctb_show.ctb_hideshow {
  display: block;
}
.ctb_global_show .ctb_show + .input_area,
.ctb_global_show .ctb_show + div.text_cell_input,
.ctb_global_show .ctb_show ~ div.text_cell_render {
  border-top-right-radius: 0px;
  border-top-left-radius: 0px;
}
.ctb_global_show .ctb_show ~ div.text_cell_render {
  border: 1px solid #cfcfcf;
}
.celltoolbar {
  font-size: 87%;
  padding-top: 3px;
}
.celltoolbar select {
  display: block;
  width: 100%;
  height: 32px;
  padding: 6px 12px;
  font-size: 13px;
  line-height: 1.42857143;
  color: #555555;
  background-color: #fff;
  background-image: none;
  border: 1px solid #ccc;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  -webkit-transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  -o-transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  height: 30px;
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
  width: inherit;
  font-size: inherit;
  height: 22px;
  padding: 0px;
  display: inline-block;
}
.celltoolbar select:focus {
  border-color: #66afe9;
  outline: 0;
  -webkit-box-shadow: inset 0 1px 1px rgba(0,0,0,.075), 0 0 8px rgba(102, 175, 233, 0.6);
  box-shadow: inset 0 1px 1px rgba(0,0,0,.075), 0 0 8px rgba(102, 175, 233, 0.6);
}
.celltoolbar select::-moz-placeholder {
  color: #999;
  opacity: 1;
}
.celltoolbar select:-ms-input-placeholder {
  color: #999;
}
.celltoolbar select::-webkit-input-placeholder {
  color: #999;
}
.celltoolbar select::-ms-expand {
  border: 0;
  background-color: transparent;
}
.celltoolbar select[disabled],
.celltoolbar select[readonly],
fieldset[disabled] .celltoolbar select {
  background-color: #eeeeee;
  opacity: 1;
}
.celltoolbar select[disabled],
fieldset[disabled] .celltoolbar select {
  cursor: not-allowed;
}
textarea.celltoolbar select {
  height: auto;
}
select.celltoolbar select {
  height: 30px;
  line-height: 30px;
}
textarea.celltoolbar select,
select[multiple].celltoolbar select {
  height: auto;
}
.celltoolbar label {
  margin-left: 5px;
  margin-right: 5px;
}
.completions {
  position: absolute;
  z-index: 110;
  overflow: hidden;
  border: 1px solid #ababab;
  border-radius: 2px;
  -webkit-box-shadow: 0px 6px 10px -1px #adadad;
  box-shadow: 0px 6px 10px -1px #adadad;
  line-height: 1;
}
.completions select {
  background: white;
  outline: none;
  border: none;
  padding: 0px;
  margin: 0px;
  overflow: auto;
  font-family: monospace;
  font-size: 110%;
  color: #000;
  width: auto;
}
.completions select option.context {
  color: #286090;
}
#kernel_logo_widget {
  float: right !important;
  float: right;
}
#kernel_logo_widget .current_kernel_logo {
  display: none;
  margin-top: -1px;
  margin-bottom: -1px;
  width: 32px;
  height: 32px;
}
#menubar {
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  margin-top: 1px;
}
#menubar .navbar {
  border-top: 1px;
  border-radius: 0px 0px 2px 2px;
  margin-bottom: 0px;
}
#menubar .navbar-toggle {
  float: left;
  padding-top: 7px;
  padding-bottom: 7px;
  border: none;
}
#menubar .navbar-collapse {
  clear: left;
}
.nav-wrapper {
  border-bottom: 1px solid #e7e7e7;
}
i.menu-icon {
  padding-top: 4px;
}
ul#help_menu li a {
  overflow: hidden;
  padding-right: 2.2em;
}
ul#help_menu li a i {
  margin-right: -1.2em;
}
.dropdown-submenu {
  position: relative;
}
.dropdown-submenu > .dropdown-menu {
  top: 0;
  left: 100%;
  margin-top: -6px;
  margin-left: -1px;
}
.dropdown-submenu:hover > .dropdown-menu {
  display: block;
}
.dropdown-submenu > a:after {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  display: block;
  content: "\f0da";
  float: right;
  color: #333333;
  margin-top: 2px;
  margin-right: -10px;
}
.dropdown-submenu > a:after.pull-left {
  margin-right: .3em;
}
.dropdown-submenu > a:after.pull-right {
  margin-left: .3em;
}
.dropdown-submenu:hover > a:after {
  color: #262626;
}
.dropdown-submenu.pull-left {
  float: none;
}
.dropdown-submenu.pull-left > .dropdown-menu {
  left: -100%;
  margin-left: 10px;
}
#notification_area {
  float: right !important;
  float: right;
  z-index: 10;
}
.indicator_area {
  float: right !important;
  float: right;
  color: #777;
  margin-left: 5px;
  margin-right: 5px;
  width: 11px;
  z-index: 10;
  text-align: center;
  width: auto;
}
#kernel_indicator {
  float: right !important;
  float: right;
  color: #777;
  margin-left: 5px;
  margin-right: 5px;
  width: 11px;
  z-index: 10;
  text-align: center;
  width: auto;
  border-left: 1px solid;
}
#kernel_indicator .kernel_indicator_name {
  padding-left: 5px;
  padding-right: 5px;
}
#modal_indicator {
  float: right !important;
  float: right;
  color: #777;
  margin-left: 5px;
  margin-right: 5px;
  width: 11px;
  z-index: 10;
  text-align: center;
  width: auto;
}
#readonly-indicator {
  float: right !important;
  float: right;
  color: #777;
  margin-left: 5px;
  margin-right: 5px;
  width: 11px;
  z-index: 10;
  text-align: center;
  width: auto;
  margin-top: 2px;
  margin-bottom: 0px;
  margin-left: 0px;
  margin-right: 0px;
  display: none;
}
.modal_indicator:before {
  width: 1.28571429em;
  text-align: center;
}
.edit_mode .modal_indicator:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f040";
}
.edit_mode .modal_indicator:before.pull-left {
  margin-right: .3em;
}
.edit_mode .modal_indicator:before.pull-right {
  margin-left: .3em;
}
.command_mode .modal_indicator:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: ' ';
}
.command_mode .modal_indicator:before.pull-left {
  margin-right: .3em;
}
.command_mode .modal_indicator:before.pull-right {
  margin-left: .3em;
}
.kernel_idle_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f10c";
}
.kernel_idle_icon:before.pull-left {
  margin-right: .3em;
}
.kernel_idle_icon:before.pull-right {
  margin-left: .3em;
}
.kernel_busy_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f111";
}
.kernel_busy_icon:before.pull-left {
  margin-right: .3em;
}
.kernel_busy_icon:before.pull-right {
  margin-left: .3em;
}
.kernel_dead_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f1e2";
}
.kernel_dead_icon:before.pull-left {
  margin-right: .3em;
}
.kernel_dead_icon:before.pull-right {
  margin-left: .3em;
}
.kernel_disconnected_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f127";
}
.kernel_disconnected_icon:before.pull-left {
  margin-right: .3em;
}
.kernel_disconnected_icon:before.pull-right {
  margin-left: .3em;
}
.notification_widget {
  color: #777;
  z-index: 10;
  background: rgba(240, 240, 240, 0.5);
  margin-right: 4px;
  color: #333;
  background-color: #fff;
  border-color: #ccc;
}
.notification_widget:focus,
.notification_widget.focus {
  color: #333;
  background-color: #e6e6e6;
  border-color: #8c8c8c;
}
.notification_widget:hover {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
.notification_widget:active,
.notification_widget.active,
.open > .dropdown-toggle.notification_widget {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
.notification_widget:active:hover,
.notification_widget.active:hover,
.open > .dropdown-toggle.notification_widget:hover,
.notification_widget:active:focus,
.notification_widget.active:focus,
.open > .dropdown-toggle.notification_widget:focus,
.notification_widget:active.focus,
.notification_widget.active.focus,
.open > .dropdown-toggle.notification_widget.focus {
  color: #333;
  background-color: #d4d4d4;
  border-color: #8c8c8c;
}
.notification_widget:active,
.notification_widget.active,
.open > .dropdown-toggle.notification_widget {
  background-image: none;
}
.notification_widget.disabled:hover,
.notification_widget[disabled]:hover,
fieldset[disabled] .notification_widget:hover,
.notification_widget.disabled:focus,
.notification_widget[disabled]:focus,
fieldset[disabled] .notification_widget:focus,
.notification_widget.disabled.focus,
.notification_widget[disabled].focus,
fieldset[disabled] .notification_widget.focus {
  background-color: #fff;
  border-color: #ccc;
}
.notification_widget .badge {
  color: #fff;
  background-color: #333;
}
.notification_widget.warning {
  color: #fff;
  background-color: #f0ad4e;
  border-color: #eea236;
}
.notification_widget.warning:focus,
.notification_widget.warning.focus {
  color: #fff;
  background-color: #ec971f;
  border-color: #985f0d;
}
.notification_widget.warning:hover {
  color: #fff;
  background-color: #ec971f;
  border-color: #d58512;
}
.notification_widget.warning:active,
.notification_widget.warning.active,
.open > .dropdown-toggle.notification_widget.warning {
  color: #fff;
  background-color: #ec971f;
  border-color: #d58512;
}
.notification_widget.warning:active:hover,
.notification_widget.warning.active:hover,
.open > .dropdown-toggle.notification_widget.warning:hover,
.notification_widget.warning:active:focus,
.notification_widget.warning.active:focus,
.open > .dropdown-toggle.notification_widget.warning:focus,
.notification_widget.warning:active.focus,
.notification_widget.warning.active.focus,
.open > .dropdown-toggle.notification_widget.warning.focus {
  color: #fff;
  background-color: #d58512;
  border-color: #985f0d;
}
.notification_widget.warning:active,
.notification_widget.warning.active,
.open > .dropdown-toggle.notification_widget.warning {
  background-image: none;
}
.notification_widget.warning.disabled:hover,
.notification_widget.warning[disabled]:hover,
fieldset[disabled] .notification_widget.warning:hover,
.notification_widget.warning.disabled:focus,
.notification_widget.warning[disabled]:focus,
fieldset[disabled] .notification_widget.warning:focus,
.notification_widget.warning.disabled.focus,
.notification_widget.warning[disabled].focus,
fieldset[disabled] .notification_widget.warning.focus {
  background-color: #f0ad4e;
  border-color: #eea236;
}
.notification_widget.warning .badge {
  color: #f0ad4e;
  background-color: #fff;
}
.notification_widget.success {
  color: #fff;
  background-color: #5cb85c;
  border-color: #4cae4c;
}
.notification_widget.success:focus,
.notification_widget.success.focus {
  color: #fff;
  background-color: #449d44;
  border-color: #255625;
}
.notification_widget.success:hover {
  color: #fff;
  background-color: #449d44;
  border-color: #398439;
}
.notification_widget.success:active,
.notification_widget.success.active,
.open > .dropdown-toggle.notification_widget.success {
  color: #fff;
  background-color: #449d44;
  border-color: #398439;
}
.notification_widget.success:active:hover,
.notification_widget.success.active:hover,
.open > .dropdown-toggle.notification_widget.success:hover,
.notification_widget.success:active:focus,
.notification_widget.success.active:focus,
.open > .dropdown-toggle.notification_widget.success:focus,
.notification_widget.success:active.focus,
.notification_widget.success.active.focus,
.open > .dropdown-toggle.notification_widget.success.focus {
  color: #fff;
  background-color: #398439;
  border-color: #255625;
}
.notification_widget.success:active,
.notification_widget.success.active,
.open > .dropdown-toggle.notification_widget.success {
  background-image: none;
}
.notification_widget.success.disabled:hover,
.notification_widget.success[disabled]:hover,
fieldset[disabled] .notification_widget.success:hover,
.notification_widget.success.disabled:focus,
.notification_widget.success[disabled]:focus,
fieldset[disabled] .notification_widget.success:focus,
.notification_widget.success.disabled.focus,
.notification_widget.success[disabled].focus,
fieldset[disabled] .notification_widget.success.focus {
  background-color: #5cb85c;
  border-color: #4cae4c;
}
.notification_widget.success .badge {
  color: #5cb85c;
  background-color: #fff;
}
.notification_widget.info {
  color: #fff;
  background-color: #5bc0de;
  border-color: #46b8da;
}
.notification_widget.info:focus,
.notification_widget.info.focus {
  color: #fff;
  background-color: #31b0d5;
  border-color: #1b6d85;
}
.notification_widget.info:hover {
  color: #fff;
  background-color: #31b0d5;
  border-color: #269abc;
}
.notification_widget.info:active,
.notification_widget.info.active,
.open > .dropdown-toggle.notification_widget.info {
  color: #fff;
  background-color: #31b0d5;
  border-color: #269abc;
}
.notification_widget.info:active:hover,
.notification_widget.info.active:hover,
.open > .dropdown-toggle.notification_widget.info:hover,
.notification_widget.info:active:focus,
.notification_widget.info.active:focus,
.open > .dropdown-toggle.notification_widget.info:focus,
.notification_widget.info:active.focus,
.notification_widget.info.active.focus,
.open > .dropdown-toggle.notification_widget.info.focus {
  color: #fff;
  background-color: #269abc;
  border-color: #1b6d85;
}
.notification_widget.info:active,
.notification_widget.info.active,
.open > .dropdown-toggle.notification_widget.info {
  background-image: none;
}
.notification_widget.info.disabled:hover,
.notification_widget.info[disabled]:hover,
fieldset[disabled] .notification_widget.info:hover,
.notification_widget.info.disabled:focus,
.notification_widget.info[disabled]:focus,
fieldset[disabled] .notification_widget.info:focus,
.notification_widget.info.disabled.focus,
.notification_widget.info[disabled].focus,
fieldset[disabled] .notification_widget.info.focus {
  background-color: #5bc0de;
  border-color: #46b8da;
}
.notification_widget.info .badge {
  color: #5bc0de;
  background-color: #fff;
}
.notification_widget.danger {
  color: #fff;
  background-color: #d9534f;
  border-color: #d43f3a;
}
.notification_widget.danger:focus,
.notification_widget.danger.focus {
  color: #fff;
  background-color: #c9302c;
  border-color: #761c19;
}
.notification_widget.danger:hover {
  color: #fff;
  background-color: #c9302c;
  border-color: #ac2925;
}
.notification_widget.danger:active,
.notification_widget.danger.active,
.open > .dropdown-toggle.notification_widget.danger {
  color: #fff;
  background-color: #c9302c;
  border-color: #ac2925;
}
.notification_widget.danger:active:hover,
.notification_widget.danger.active:hover,
.open > .dropdown-toggle.notification_widget.danger:hover,
.notification_widget.danger:active:focus,
.notification_widget.danger.active:focus,
.open > .dropdown-toggle.notification_widget.danger:focus,
.notification_widget.danger:active.focus,
.notification_widget.danger.active.focus,
.open > .dropdown-toggle.notification_widget.danger.focus {
  color: #fff;
  background-color: #ac2925;
  border-color: #761c19;
}
.notification_widget.danger:active,
.notification_widget.danger.active,
.open > .dropdown-toggle.notification_widget.danger {
  background-image: none;
}
.notification_widget.danger.disabled:hover,
.notification_widget.danger[disabled]:hover,
fieldset[disabled] .notification_widget.danger:hover,
.notification_widget.danger.disabled:focus,
.notification_widget.danger[disabled]:focus,
fieldset[disabled] .notification_widget.danger:focus,
.notification_widget.danger.disabled.focus,
.notification_widget.danger[disabled].focus,
fieldset[disabled] .notification_widget.danger.focus {
  background-color: #d9534f;
  border-color: #d43f3a;
}
.notification_widget.danger .badge {
  color: #d9534f;
  background-color: #fff;
}
div#pager {
  background-color: #fff;
  font-size: 14px;
  line-height: 20px;
  overflow: hidden;
  display: none;
  position: fixed;
  bottom: 0px;
  width: 100%;
  max-height: 50%;
  padding-top: 8px;
  -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  /* Display over codemirror */
  z-index: 100;
  /* Hack which prevents jquery ui resizable from changing top. */
  top: auto !important;
}
div#pager pre {
  line-height: 1.21429em;
  color: #000;
  background-color: #f7f7f7;
  padding: 0.4em;
}
div#pager #pager-button-area {
  position: absolute;
  top: 8px;
  right: 20px;
}
div#pager #pager-contents {
  position: relative;
  overflow: auto;
  width: 100%;
  height: 100%;
}
div#pager #pager-contents #pager-container {
  position: relative;
  padding: 15px 0px;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
}
div#pager .ui-resizable-handle {
  top: 0px;
  height: 8px;
  background: #f7f7f7;
  border-top: 1px solid #cfcfcf;
  border-bottom: 1px solid #cfcfcf;
  /* This injects handle bars (a short, wide = symbol) for 
        the resize handle. */
}
div#pager .ui-resizable-handle::after {
  content: '';
  top: 2px;
  left: 50%;
  height: 3px;
  width: 30px;
  margin-left: -15px;
  position: absolute;
  border-top: 1px solid #cfcfcf;
}
.quickhelp {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
  line-height: 1.8em;
}
.shortcut_key {
  display: inline-block;
  width: 21ex;
  text-align: right;
  font-family: monospace;
}
.shortcut_descr {
  display: inline-block;
  /* Old browsers */
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<h2 id="Genome-informatics">Genome informatics<a class="anchor-link" href="#Genome-informatics">&#182;</a></h2><h1 id="RNA-Seq-analysis-:-Differential-expression">RNA-Seq analysis : Differential expression<a class="anchor-link" href="#RNA-Seq-analysis-:-Differential-expression">&#182;</a></h1>
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<h2 id="Differential-expression">Differential expression<a class="anchor-link" href="#Differential-expression">&#182;</a></h2><ul>
<li>A gene or transcript is declared differentially expressed if an observed change in read counts between two experimental conditions is statistically significant, i.e. if the difference is greater than what would be expected just due to random variation.</li>
<li>Detecting differentially expressed genes/transcripts across sample groups is among the major goals in the statistical analysis of RNA-seq data.</li>
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<div class="prompt input_prompt">In&nbsp;[8]:</div>
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<div class=" highlight hl-ipython3"><pre><span></span><span class="n">df</span><span class="o">.</span><span class="n">head</span><span class="p">(</span><span class="mi">10</span><span class="p">)</span>
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      <td>589</td>
      <td>818</td>
    </tr>
    <tr>
      <th>ABHD16B</th>
      <td>2184</td>
      <td>970</td>
      <td>2964</td>
      <td>1270</td>
      <td>3148</td>
      <td>2138</td>
      <td>2796</td>
      <td>3507</td>
      <td>731</td>
      <td>1045</td>
    </tr>
    <tr>
      <th>AC005220.1</th>
      <td>2101</td>
      <td>749</td>
      <td>2459</td>
      <td>1140</td>
      <td>2518</td>
      <td>1806</td>
      <td>2111</td>
      <td>2650</td>
      <td>583</td>
      <td>607</td>
    </tr>
    <tr>
      <th>AC005808.1</th>
      <td>216</td>
      <td>134</td>
      <td>542</td>
      <td>158</td>
      <td>310</td>
      <td>228</td>
      <td>324</td>
      <td>439</td>
      <td>77</td>
      <td>95</td>
    </tr>
  </tbody>
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<h2 id="Between-sample-normalization">Between-sample normalization<a class="anchor-link" href="#Between-sample-normalization">&#182;</a></h2><ul>
<li>The general point of between-sample normalization (BSN) is to be able to compare expression features (genes, transcripts) ACROSS experiments. This is not to be confused with <a href="https://haroldpimentel.wordpress.com/2014/05/08/what-the-fpkm-a-review-rna-seq-expression-units/">within-sample normalization methods</a> (comparing different features within a single sample). </li>
</ul>
<p><img src="images/kogo-2013-rnaseq-analysis-79-638.jpg" width="600"></p>
<ul>
<li>Most BSN methods address two issues :<ul>
<li>Variable sequencing depth (the total number of reads sequenced) between experiments.</li>
<li>Finding a “control set” of expression features which should have relatively similar expression patterns across experiments (e.g. genes that are not differentially expressed) to serve as a baseline.</li>
</ul>
</li>
</ul>

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<p><img src="images/pie_charts.png" width="700">
Harold Pimentel: <a href="https://haroldpimentel.wordpress.com/2014/12/08/in-rna-seq-2-2-between-sample-normalization/"><strong>In RNA-Seq, 2 != 2: Between-sample normalization</strong></a></p>

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<ul>
<li>One way to do the total count normalization would be to divide by the total counts :</li>
</ul>
<table>
<thead><tr>
<th>Gene</th>
<th>Control Counts</th>
<th>Treatment Counts</th>
<th>Control Normalized</th>
<th>Treatment Normalized</th>
</tr>
</thead>
<tbody>
<tr>
<td>G1</td>
<td>2.00</td>
<td>6.00</td>
<td>0.20</td>
<td>0.06</td>
</tr>
<tr>
<td>G2</td>
<td>2.00</td>
<td>6.00</td>
<td>0.20</td>
<td>0.06</td>
</tr>
<tr>
<td>G3</td>
<td>2.00</td>
<td>6.00</td>
<td>0.20</td>
<td>0.06</td>
</tr>
<tr>
<td>G4</td>
<td>2.00</td>
<td>6.00</td>
<td>0.20</td>
<td>0.06</td>
</tr>
<tr>
<td>FG</td>
<td>2.00</td>
<td>76.00</td>
<td>0.20</td>
<td>0.76</td>
</tr>
</tbody>
</table>

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<ul>
<li>If one compares the control and treatment proportions, it seems that every gene is differentially expressed. We are typically under the assumption that the majority of the genes do not change in expression. Under that assumption, it is much more plausible that genes one through four remain equally expressed, whereas “funky gene” (FG) is the only differentially expressed gene.</li>
</ul>

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<ul>
<li>We might consider normalizing by the sum of the total counts while omitting the last gene since its highly overexpressed and is throwing off the normalization :</li>
</ul>
<table>
<thead><tr>
<th>Gene</th>
<th>Control Counts</th>
<th>Treatment Counts</th>
<th>Control Normalized</th>
<th>Treatment Normalized</th>
</tr>
</thead>
<tbody>
<tr>
<td>G1</td>
<td>2.00</td>
<td>6.00</td>
<td>0.25</td>
<td>0.25</td>
</tr>
<tr>
<td>G2</td>
<td>2.00</td>
<td>6.00</td>
<td>0.25</td>
<td>0.25</td>
</tr>
<tr>
<td>G3</td>
<td>2.00</td>
<td>6.00</td>
<td>0.25</td>
<td>0.25</td>
</tr>
<tr>
<td>G4</td>
<td>2.00</td>
<td>6.00</td>
<td>0.25</td>
<td>0.25</td>
</tr>
<tr>
<td>FG</td>
<td>2.00</td>
<td>76.00</td>
<td>0.25</td>
<td>3.17</td>
</tr>
</tbody>
</table>

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<ul>
<li>Between sample normalization procedures estimate <strong>sample-specific normalization factors</strong> that are used to rescale the observed counts. </li>
<li>Using these normalization methods, the sum of the normalized counts across all genes are therefore not necessarily equal between samples (as it would be if only the library sizes were used for normalization), but the goal is instead to make the normalized counts for non-differentially expressed genes similar between the samples.</li>
</ul>

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<ul>
<li>Popular examples of these normalization procedures are <strong>TMM</strong> (trimmed mean of M-values) and <strong>DESeq</strong>. These two methods perform similarly and are both based on an assumption that most genes are equivalently expressed in the samples, and that the differentially expressed genes are divided more or less equally between up- and downregulation.</li>
</ul>

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<p><img src="images/rankedgl.jpg" width="200"></p>

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<ul>
<li>With <strong>DESeq</strong> sample-specific normalization constants are estimated with the median-of-ratios method:</li>
</ul>
<p><img src="images/form1.png" width="200"><img src="images/form2.png" width="200"></p>

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<ul>
<li>Let's try estimating sample specific normalization factor for the two dummy samples from the example. We first calculate the geometric means for each gene:</li>
</ul>
<table>
<thead><tr>
<th>Gene</th>
<th>Control Counts</th>
<th>Treatment Counts</th>
<th>KiR</th>
</tr>
</thead>
<tbody>
<tr>
<td>G1</td>
<td>2.00</td>
<td>6.00</td>
<td>3.464</td>
</tr>
<tr>
<td>G2</td>
<td>2.00</td>
<td>6.00</td>
<td>3.464</td>
</tr>
<tr>
<td>G3</td>
<td>2.00</td>
<td>6.00</td>
<td>3.464</td>
</tr>
<tr>
<td>G4</td>
<td>2.00</td>
<td>6.00</td>
<td>3.464</td>
</tr>
<tr>
<td>FG</td>
<td>2.00</td>
<td>76.00</td>
<td>12.329</td>
</tr>
</tbody>
</table>

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<ul>
<li>Next we divide each count with the geometric mean expression for that gene:</li>
</ul>
<table>
<thead><tr>
<th>Gene</th>
<th>Control Counts/KiR</th>
<th>Treatment Counts/KiR</th>
</tr>
</thead>
<tbody>
<tr>
<td>G1</td>
<td>0.57735</td>
<td>1.73205</td>
</tr>
<tr>
<td>G2</td>
<td>0.57735</td>
<td>1.73205</td>
</tr>
<tr>
<td>G3</td>
<td>0.57735</td>
<td>1.73205</td>
</tr>
<tr>
<td>G4</td>
<td>0.57735</td>
<td>1.73205</td>
</tr>
<tr>
<td>FG</td>
<td>0.16222</td>
<td>6.16441</td>
</tr>
</tbody>
</table>
<p><br></p>
<ul>
<li>It is obvious that sample specific normalization factors are 0.57735 and 1.73205 (sample medians).</li>
</ul>

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<ul>
<li>Finally we divide each sample by its normalization factor:</li>
</ul>
<table>
<thead><tr>
<th>Gene</th>
<th>Control Normalized</th>
<th>Treatment Normalized</th>
</tr>
</thead>
<tbody>
<tr>
<td>G1</td>
<td>3.4641</td>
<td>3.4641</td>
</tr>
<tr>
<td>G2</td>
<td>3.4641</td>
<td>3.4641</td>
</tr>
<tr>
<td>G3</td>
<td>3.4641</td>
<td>3.4641</td>
</tr>
<tr>
<td>G4</td>
<td>3.4641</td>
<td>3.4641</td>
</tr>
<tr>
<td>FG</td>
<td>3.4641</td>
<td>43.87864</td>
</tr>
</tbody>
</table>

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<p>Normalized, this is how our simulated dataset looks like:</p>

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<div class=" highlight hl-ipython3"><pre><span></span><span class="n">normdf</span><span class="o">.</span><span class="n">head</span><span class="p">(</span><span class="mi">10</span><span class="p">)</span>
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<style scoped>
    .dataframe tbody tr th:only-of-type {
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<table border="1" class="dataframe">
  <thead>
    <tr style="text-align: right;">
      <th></th>
      <th>sample_01</th>
      <th>sample_02</th>
      <th>sample_03</th>
      <th>sample_04</th>
      <th>sample_05</th>
      <th>sample_06</th>
      <th>sample_07</th>
      <th>sample_08</th>
      <th>sample_09</th>
      <th>sample_10</th>
    </tr>
  </thead>
  <tbody>
    <tr>
      <th>AAR2</th>
      <td>876.405542</td>
      <td>918.567371</td>
      <td>817.491511</td>
      <td>797.269235</td>
      <td>805.068272</td>
      <td>766.348379</td>
      <td>1104.531722</td>
      <td>820.321403</td>
      <td>853.134999</td>
      <td>843.576787</td>
    </tr>
    <tr>
      <th>ABALON</th>
      <td>1718.982145</td>
      <td>1818.981236</td>
      <td>1918.008492</td>
      <td>1590.414664</td>
      <td>1890.630296</td>
      <td>2040.143658</td>
      <td>1596.677503</td>
      <td>1805.451382</td>
      <td>1596.829941</td>
      <td>1811.772872</td>
    </tr>
    <tr>
      <th>ABBA01031660.1</th>
      <td>426.401978</td>
      <td>421.161324</td>
      <td>464.483813</td>
      <td>519.599605</td>
      <td>473.368765</td>
      <td>489.921261</td>
      <td>503.330911</td>
      <td>460.400735</td>
      <td>343.243819</td>
      <td>452.463913</td>
    </tr>
    <tr>
      <th>ABBA01031661.1</th>
      <td>727.715553</td>
      <td>776.970029</td>
      <td>707.254019</td>
      <td>670.805839</td>
      <td>678.191788</td>
      <td>866.722491</td>
      <td>806.028529</td>
      <td>773.005392</td>
      <td>895.418658</td>
      <td>707.454169</td>
    </tr>
    <tr>
      <th>ABBA01031663.1</th>
      <td>499.566893</td>
      <td>452.022283</td>
      <td>431.660290</td>
      <td>452.244101</td>
      <td>672.502260</td>
      <td>397.513349</td>
      <td>537.585376</td>
      <td>506.653465</td>
      <td>420.349315</td>
      <td>456.298353</td>
    </tr>
    <tr>
      <th>ABBA01031674.1</th>
      <td>472.031710</td>
      <td>408.453870</td>
      <td>440.330655</td>
      <td>445.371090</td>
      <td>434.111019</td>
      <td>470.005763</td>
      <td>450.900608</td>
      <td>472.096828</td>
      <td>420.349315</td>
      <td>440.960593</td>
    </tr>
    <tr>
      <th>ABHD12</th>
      <td>1611.201571</td>
      <td>1635.630832</td>
      <td>1527.842089</td>
      <td>1556.049611</td>
      <td>1603.878063</td>
      <td>1638.647210</td>
      <td>1603.668210</td>
      <td>1582.693983</td>
      <td>1465.004416</td>
      <td>1568.285935</td>
    </tr>
    <tr>
      <th>ABHD16B</th>
      <td>1718.195425</td>
      <td>1760.890019</td>
      <td>1835.640029</td>
      <td>1745.744705</td>
      <td>1791.063549</td>
      <td>1703.173425</td>
      <td>1954.601706</td>
      <td>1864.463486</td>
      <td>1818.197331</td>
      <td>2003.494869</td>
    </tr>
    <tr>
      <th>AC005220.1</th>
      <td>1652.897705</td>
      <td>1359.697551</td>
      <td>1522.887595</td>
      <td>1567.046428</td>
      <td>1432.623258</td>
      <td>1438.695606</td>
      <td>1475.738270</td>
      <td>1408.847516</td>
      <td>1450.080772</td>
      <td>1163.752522</td>
    </tr>
    <tr>
      <th>AC005808.1</th>
      <td>169.931416</td>
      <td>243.256972</td>
      <td>335.666969</td>
      <td>217.187136</td>
      <td>176.375381</td>
      <td>181.629346</td>
      <td>226.498910</td>
      <td>233.390211</td>
      <td>191.520102</td>
      <td>182.135897</td>
    </tr>
  </tbody>
</table>
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<h2 id="Exploratory-analysis">Exploratory analysis<a class="anchor-link" href="#Exploratory-analysis">&#182;</a></h2><p>Data quality assessment and quality control (i.e. the removal of insufficiently good data) are essential steps of any data analysis. These steps should typically be performed very early in the analysis of a new data set, preceding or in parallel to the differential expression testing.</p>
<p>The dataset we are investigating is simulated, but let us pretend that samples 6 through 10 are coming from the "treated" population and that samples 1 through 5 are "untreated" or "control" samples.</p>

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<p><img src="images/pca.gif" width="500"></p>

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<div class=" highlight hl-ipython3"><pre><span></span><span class="kn">from</span> <span class="nn">sklearn.decomposition</span> <span class="k">import</span> <span class="n">PCA</span>
<span class="kn">from</span> <span class="nn">sklearn.preprocessing</span> <span class="k">import</span> <span class="n">StandardScaler</span>

<span class="n">pca</span> <span class="o">=</span> <span class="n">PCA</span><span class="p">(</span><span class="n">n_components</span><span class="o">=</span><span class="mi">2</span><span class="p">)</span>

<span class="n">principalComponents</span> <span class="o">=</span> <span class="n">pca</span><span class="o">.</span><span class="n">fit_transform</span><span class="p">(</span><span class="n">normdf</span><span class="o">.</span><span class="n">T</span><span class="p">)</span>
<span class="n">principalComponents</span>
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<pre>array([[ 7253.66901946, -1133.0858518 ],
       [ 6777.83482879,  -351.8259295 ],
       [ 6777.5841612 ,  1550.29503569],
       [ 6891.70586134,  -334.63078674],
       [ 7100.44333788,   351.9640596 ],
       [-7020.20823953,  2833.66966978],
       [-7027.03427084, -2662.13331895],
       [-7052.22861383,   957.48901253],
       [-6578.86674374, -1450.58626455],
       [-7122.89934072,   238.84437394]])</pre>
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<div class=" highlight hl-ipython3"><pre><span></span><span class="n">principalDf</span> <span class="o">=</span> <span class="n">pd</span><span class="o">.</span><span class="n">DataFrame</span><span class="p">(</span><span class="n">data</span> <span class="o">=</span> <span class="n">principalComponents</span>
             <span class="p">,</span> <span class="n">columns</span> <span class="o">=</span> <span class="p">[</span><span class="s1">&#39;principal component 1&#39;</span><span class="p">,</span> <span class="s1">&#39;principal component 2&#39;</span><span class="p">])</span>

<span class="n">categories</span> <span class="o">=</span> <span class="n">np</span><span class="o">.</span><span class="n">array</span><span class="p">([</span><span class="s2">&quot;untreated&quot;</span><span class="p">,</span> <span class="s2">&quot;treated&quot;</span><span class="p">])</span>

<span class="n">finalDf</span> <span class="o">=</span> <span class="n">pd</span><span class="o">.</span><span class="n">concat</span><span class="p">([</span><span class="n">principalDf</span><span class="p">,</span> <span class="n">pd</span><span class="o">.</span><span class="n">DataFrame</span><span class="p">(</span><span class="n">np</span><span class="o">.</span><span class="n">repeat</span><span class="p">(</span><span class="n">categories</span><span class="p">,</span> <span class="p">[</span><span class="mi">5</span><span class="p">,</span> <span class="mi">5</span><span class="p">],</span> <span class="n">axis</span><span class="o">=</span><span class="mi">0</span><span class="p">),</span> <span class="n">columns</span><span class="o">=</span><span class="p">[</span><span class="s1">&#39;condition&#39;</span><span class="p">])],</span> <span class="n">axis</span> <span class="o">=</span> <span class="mi">1</span><span class="p">)</span>
<span class="n">finalDf</span>
</pre></div>

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<div class="prompt output_prompt">Out[13]:</div>


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<div>
<style scoped>
    .dataframe tbody tr th:only-of-type {
        vertical-align: middle;
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<table border="1" class="dataframe">
  <thead>
    <tr style="text-align: right;">
      <th></th>
      <th>principal component 1</th>
      <th>principal component 2</th>
      <th>condition</th>
    </tr>
  </thead>
  <tbody>
    <tr>
      <th>0</th>
      <td>7253.669019</td>
      <td>-1133.085852</td>
      <td>untreated</td>
    </tr>
    <tr>
      <th>1</th>
      <td>6777.834829</td>
      <td>-351.825929</td>
      <td>untreated</td>
    </tr>
    <tr>
      <th>2</th>
      <td>6777.584161</td>
      <td>1550.295036</td>
      <td>untreated</td>
    </tr>
    <tr>
      <th>3</th>
      <td>6891.705861</td>
      <td>-334.630787</td>
      <td>untreated</td>
    </tr>
    <tr>
      <th>4</th>
      <td>7100.443338</td>
      <td>351.964060</td>
      <td>untreated</td>
    </tr>
    <tr>
      <th>5</th>
      <td>-7020.208240</td>
      <td>2833.669670</td>
      <td>treated</td>
    </tr>
    <tr>
      <th>6</th>
      <td>-7027.034271</td>
      <td>-2662.133319</td>
      <td>treated</td>
    </tr>
    <tr>
      <th>7</th>
      <td>-7052.228614</td>
      <td>957.489013</td>
      <td>treated</td>
    </tr>
    <tr>
      <th>8</th>
      <td>-6578.866744</td>
      <td>-1450.586265</td>
      <td>treated</td>
    </tr>
    <tr>
      <th>9</th>
      <td>-7122.899341</td>
      <td>238.844374</td>
      <td>treated</td>
    </tr>
  </tbody>
</table>
</div>
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</div></section><section>
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<div class="prompt input_prompt">In&nbsp;[14]:</div>
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<div class=" highlight hl-ipython3"><pre><span></span><span class="n">fig</span> <span class="o">=</span> <span class="n">plt</span><span class="o">.</span><span class="n">figure</span><span class="p">(</span><span class="n">figsize</span> <span class="o">=</span> <span class="p">(</span><span class="mi">8</span><span class="p">,</span><span class="mi">6</span><span class="p">))</span>
<span class="n">ax</span> <span class="o">=</span> <span class="n">fig</span><span class="o">.</span><span class="n">add_subplot</span><span class="p">(</span><span class="mi">1</span><span class="p">,</span><span class="mi">1</span><span class="p">,</span><span class="mi">1</span><span class="p">)</span> 
<span class="n">ax</span><span class="o">.</span><span class="n">set_xlabel</span><span class="p">(</span><span class="s1">&#39;Principal Component 1&#39;</span><span class="p">,</span> <span class="n">fontsize</span> <span class="o">=</span> <span class="mi">15</span><span class="p">)</span>
<span class="n">ax</span><span class="o">.</span><span class="n">set_ylabel</span><span class="p">(</span><span class="s1">&#39;Principal Component 2&#39;</span><span class="p">,</span> <span class="n">fontsize</span> <span class="o">=</span> <span class="mi">15</span><span class="p">)</span>
<span class="n">ax</span><span class="o">.</span><span class="n">set_title</span><span class="p">(</span><span class="s1">&#39;2 Component PCA&#39;</span><span class="p">,</span> <span class="n">fontsize</span> <span class="o">=</span> <span class="mi">20</span><span class="p">)</span>
<span class="n">conditions</span> <span class="o">=</span> <span class="n">categories</span><span class="p">;</span> <span class="n">colors</span> <span class="o">=</span> <span class="p">[</span><span class="s1">&#39;r&#39;</span><span class="p">,</span> <span class="s1">&#39;g&#39;</span><span class="p">]</span>
<span class="k">for</span> <span class="n">target</span><span class="p">,</span> <span class="n">color</span> <span class="ow">in</span> <span class="nb">zip</span><span class="p">(</span><span class="n">conditions</span><span class="p">,</span><span class="n">colors</span><span class="p">):</span>
    <span class="n">indicesToKeep</span> <span class="o">=</span> <span class="n">finalDf</span><span class="p">[</span><span class="s1">&#39;condition&#39;</span><span class="p">]</span> <span class="o">==</span> <span class="n">target</span>
    <span class="n">ax</span><span class="o">.</span><span class="n">scatter</span><span class="p">(</span><span class="n">finalDf</span><span class="o">.</span><span class="n">loc</span><span class="p">[</span><span class="n">indicesToKeep</span><span class="p">,</span> <span class="s1">&#39;principal component 1&#39;</span><span class="p">],</span> 
               <span class="n">finalDf</span><span class="o">.</span><span class="n">loc</span><span class="p">[</span><span class="n">indicesToKeep</span><span class="p">,</span> <span class="s1">&#39;principal component 2&#39;</span><span class="p">],</span> 
               <span class="n">c</span> <span class="o">=</span> <span class="n">color</span><span class="p">,</span> <span class="n">s</span> <span class="o">=</span> <span class="mi">50</span><span class="p">)</span>
<span class="n">ax</span><span class="o">.</span><span class="n">legend</span><span class="p">(</span><span class="n">conditions</span><span class="p">);</span> <span class="n">ax</span><span class="o">.</span><span class="n">grid</span><span class="p">()</span>
</pre></div>

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<h2 id="Intro-to-statistical-inference">Intro to statistical inference<a class="anchor-link" href="#Intro-to-statistical-inference">&#182;</a></h2><p>For each gene, we are interested in differences in mean expression between the two sample groups.</p>

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<div class="prompt input_prompt">In&nbsp;[15]:</div>
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<div class=" highlight hl-ipython3"><pre><span></span><span class="kn">import</span> <span class="nn">seaborn</span> <span class="k">as</span> <span class="nn">sns</span>

<span class="n">aux</span> <span class="o">=</span> <span class="p">{</span><span class="s2">&quot;norm&quot;</span> <span class="p">:</span> <span class="n">normdf</span><span class="o">.</span><span class="n">loc</span><span class="p">[</span><span class="s1">&#39;AL031055.1&#39;</span><span class="p">],</span> <span class="s2">&quot;group&quot;</span> <span class="p">:</span> <span class="n">np</span><span class="o">.</span><span class="n">repeat</span><span class="p">(</span><span class="n">categories</span><span class="p">,</span> <span class="p">[</span><span class="mi">5</span><span class="p">,</span> <span class="mi">5</span><span class="p">],</span> <span class="n">axis</span><span class="o">=</span><span class="mi">0</span><span class="p">)}</span>
<span class="n">df</span> <span class="o">=</span> <span class="n">pd</span><span class="o">.</span><span class="n">DataFrame</span><span class="p">(</span><span class="n">data</span><span class="o">=</span><span class="n">aux</span><span class="p">)</span>
<span class="n">sns</span><span class="o">.</span><span class="n">stripplot</span><span class="p">(</span><span class="n">x</span><span class="o">=</span><span class="s2">&quot;group&quot;</span><span class="p">,</span> <span class="n">y</span><span class="o">=</span><span class="s2">&quot;norm&quot;</span><span class="p">,</span> <span class="n">data</span><span class="o">=</span><span class="n">df</span><span class="p">,</span> <span class="n">jitter</span><span class="o">=</span><span class="kc">True</span><span class="p">)</span><span class="o">.</span><span class="n">set_title</span><span class="p">(</span><span class="s1">&#39;AL031055.1&#39;</span><span class="p">)</span>
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<pre>Text(0.5,1,&#39;AL031055.1&#39;)</pre>
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<div class="prompt input_prompt">In&nbsp;[16]:</div>
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<div class=" highlight hl-ipython3"><pre><span></span><span class="n">aux</span> <span class="o">=</span> <span class="p">{</span><span class="s2">&quot;norm&quot;</span> <span class="p">:</span> <span class="n">normdf</span><span class="o">.</span><span class="n">loc</span><span class="p">[</span><span class="s1">&#39;AL023803.2&#39;</span><span class="p">],</span> <span class="s2">&quot;group&quot;</span> <span class="p">:</span> <span class="n">np</span><span class="o">.</span><span class="n">repeat</span><span class="p">(</span><span class="n">categories</span><span class="p">,</span> <span class="p">[</span><span class="mi">5</span><span class="p">,</span> <span class="mi">5</span><span class="p">],</span> <span class="n">axis</span><span class="o">=</span><span class="mi">0</span><span class="p">)}</span>
<span class="n">df</span> <span class="o">=</span> <span class="n">pd</span><span class="o">.</span><span class="n">DataFrame</span><span class="p">(</span><span class="n">data</span><span class="o">=</span><span class="n">aux</span><span class="p">)</span>
<span class="n">sns</span><span class="o">.</span><span class="n">stripplot</span><span class="p">(</span><span class="n">x</span><span class="o">=</span><span class="s2">&quot;group&quot;</span><span class="p">,</span> <span class="n">y</span><span class="o">=</span><span class="s2">&quot;norm&quot;</span><span class="p">,</span> <span class="n">data</span><span class="o">=</span><span class="n">df</span><span class="p">,</span> <span class="n">jitter</span><span class="o">=</span><span class="kc">True</span><span class="p">)</span><span class="o">.</span><span class="n">set_title</span><span class="p">(</span><span class="s1">&#39;AL023803.2&#39;</span><span class="p">)</span>
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<div class="prompt output_prompt">Out[16]:</div>


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<pre>Text(0.5,1,&#39;AL023803.2&#39;)</pre>
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YyKiEMKrcTMzDqVck9SPybJAWFmthMpdwQxmSwk/kF2Cw2RfVn68MIqMzOziio3IG4ALgCe4Y1zEGZm1o2VGxB/jYgphVZiZmadSrkB8ZykW4FfkR1iAlq/zNXMzLq2cgOiL1kwnFzS5stczcy6sTYDIn0Tek5EXN0B9ZiZWSfR5mWuEbEZOKMDajEzax9zfwk/PAq+/Tb43RXg27rtkHIPMT0q6Udkd19d09QYEU8WUpWZ2Y5asQjumgBbNmXLj3wfBo2AI8+vbF1dULkB0XRL7itL2gI4sX3LMTN7kxbNeCMcmix81AGxA8oKiIh4b9GFmJm1i6FHkb7L26zNtldZt9qQNEDS9yXVp+l7kgYUXZyZ2Xbb/W1wxjWwaw1U9Ya6CXDURW1vZ9vYnm9SPwucl5YvIHtc6AeKKMrM7E056oJs2rIFenTIgzO7pXIDYr+IOLtk+QpJs4soyMys3Tgc3pRy//bWSXp304KkY4F1rW0gqY+kmZKeljRX0hWpXZL+S9J8SfMkfaak/YeSGiTNkeSDhmZmFVTuCOKTZI8PbTrvsJw3nh/dkg3AiRGxWlI18Iik+4GDgeHAQRGxRdIeqf+pwP5p+hfg2vSnmZlVQLkBMQ/4NrAfMBBYCZwJzGlpg4gIYHVarE5TkIXNv0bEltRvaeozDrgxbfe4pIGShkTEku17S2Zm1h7KPcR0L/B+YD3wN7If/Gta3YLsNh3pXMVS4MGImEEWMh9MV0PdL2n/1H0osKhk88Wprfk+JzZdTdXY2Fhm+WZmtr3KHUEMi4gx27vzdJuOkZIGAvdIOhToDayPiDpJHyC7Quo4sguXt9lFzj4nAZMA6urq/P15M7OClDuCeFTSYTv6IhGxApgOjCEbGdyVVt0DND2VbjHZuYkmw4C/7+hrmpnZm1NuQLwbmCXp+XSF0TOSWjz/ACCpJo0ckNQXGA08B/ySN27RcTwwP81PAS5MVzONAlb6/IOZWeWUe4jp1B3Y9xCyK5+qyILojoiYKukR4BZJnyM7l3Fx6n8fMBZoANYCH92B1zQzs3ZS7r2YFm7vjiNiDnBkTvsK4LSc9gA+tb2vY2ZmxfDXDM3MLJcDwszMcjkgzMwslwPCzMxyOSDMzCyXA8LMzHI5IMzMLJcDwszMcpX7TWqzrfzl5VV8/dfzWPDKat538Fv54qkH0rtnVaXLMrN25ICw7bZlSzBhcj1/XbYWgBv+9CJ9qntw+ZiDKlyZmbUnH2Ky7fbiq2teD4cmf5jvZ3OYdTcOCNtuQwf2pX+frQefBw/pX6FqzKwoDgjbbn2qq/jOuUcwuF8vAI7aeyCXn3Jghasys/bmcxC2Q055+1s58aA9eG3dRgb1613pcsysAB5B2A6rrurhcDDrxhwQZmaWq7CAkNRH0kxJT0uaK+mKZuuvkbS6ZLm3pNslNUiaIam2qNrMzKxtRY4gNgAnRsQRwEhgTHrWNJLqgIHN+k8AlkfECOBq4KoCazMzszYUFhCRaRohVKcp0jOqvwNc3myTccDkNH8ncJIkFVWfmZm1rtBzEJKqJM0GlgIPRsQM4NPAlIhY0qz7UGARQERsAlYCg3L2OVFSvaT6xkZ/OcvMrCiFBkREbI6IkcAw4GhJ7wHOBa7J6Z43WoicfU6KiLqIqKupqWnfgs3M7HUdchVTRKwApgPvBUYADZJeAnaR1JC6LQaGA0jqCQwAlnVEfWZmtq0ir2KqkTQwzfcFRgOzIuKtEVEbEbXA2nRSGmAKcFGaPwd4KCK2GUGYmVnHKPKb1EOAyemkdA/gjoiY2kr/64Gb0ohiGTC+wNrMzKwNhQVERMwBjmyjT7+S+fVk5yfMzKwT8DepzcwslwPCzMxyOSDMzCyXA8LMzHI5IMzMLJcDwszMcjkgzMwslwPCzMxyOSDMzCyXA8LMzHI5IMzMLJcDwszMcjkgzMwslwPCzMxyOSDMzCyXA8LMzHIV+cjRPpJmSnpa0lxJV6T2WyQ9L+lZSTdIqk7tkvRDSQ2S5kg6qqjazMysbUWOIDYAJ0bEEcBIYIykUcAtwEHAYUBf4OLU/1Rg/zRNBK4tsDYzM2tDYQERmdVpsTpNERH3pXUBzASGpT7jgBvTqseBgZKGFFWfmZm1rtBzEJKqJM0GlgIPRsSMknXVwAXAA6lpKLCoZPPFqa35PidKqpdU39jYWFzxZmY7uUIDIiI2R8RIslHC0ZIOLVn9Y+CPEfFwWlbeLnL2OSki6iKirqampv2LNjMzoIOuYoqIFcB0YAyApK8CNcClJd0WA8NLlocBf++I+szMbFtFXsVUI2lgmu8LjAaek3QxcArwoYjYUrLJFODCdDXTKGBlRCwpqj4zM2tdzwL3PQSYLKmKLIjuiIipkjYBC4HHJAHcHRFXAvcBY4EGYC3w0QJrMzOzNhQWEBExBzgypz33NdNVTZ8qqh4zM9s+/iZ1N7V5S5BlrpnZjinyEJNVwJYtwZVT/8xtM//KLr2quPTkA7lg1D6VLsvMuiCPILqZu5/6Gz979CU2bNrC8rUb+c9fPsv8l1dVuiwz64IcEN3M7EXLt2l7etGKClRiZl2dA6KbOXrfQVst9xC8s3b3ClVjZl2Zz0F0M2ccsRcLGldz8+ML2bV3Ty593wHUDt610mWZWRekrnylS11dXdTX11e6DDOzLkXSrIioa6ufDzGZmVkuB4SZmeVyQJiZWS4HhJmZ5XJAmJlZLgeEmZnlckCYmVkuB4SZmeVyQJiZWa4iHznaR9JMSU9LmivpitS+r6QZkv4i6XZJvVJ777TckNbXFlWbmZm1rcgRxAbgxIg4AhgJjEnPmr4KuDoi9geWAxNS/wnA8ogYAVyd+pmZWYUUFhCRWZ0Wq9MUwInAnal9MnBmmh+XlknrT1J6aLWZmXW8Qs9BSKqSNBtYCjwIvACsiIhNqctiYGiaHwosAkjrVwJb37s62+dESfWS6hsbG4ss38xsp1ZoQETE5ogYCQwDjgYOzuuW/swbLWxzq9mImBQRdRFRV1NT037FmpnZVjrkKqaIWAFMB0YBAyU1PYdiGPD3NL8YGA6Q1g8AlnVEfWZmtq0ir2KqkTQwzfcFRgPzgGnAOanbRcC9aX5KWiatfyi68sMqzMy6uCKfKDcEmCypiiyI7oiIqZL+DPxc0teBp4DrU//rgZskNZCNHMYXWJuZmbWhsICIiDnAkTntC8jORzRvXw+cW1Q9Zma2ffxNajMzy+WAMDOzXA4IMzPL5YAwM7NcDggzM8tV5GWu1s088OwSHn3hVQ4dOoCzjxpGVQ/fKsusO3NAWFl+8ocX+Nb9z72+PHvRCr5x1mEVrMjMiuZDTFaWmx5buNXyL+oXsX7j5gpVY2YdwQFhZdmlV9VWy316VtHTh5jMujUHhJXlc+87YKtzDpeM3p+eVf74mHVnPgdhZRl72BDevld/ZixYxqFDB3DIXv0rXZKZFcwBYWXbZ9Cu7DNo10qXYWYdxMcIzMwslwPCzMxyOSDMzCyXA8LMzHI5IMzMLJcDwszMcikiKl3DDpPUCCxss6OVazDwSqWLMMvhz2b72iciatrq1KUDwtqXpPqIqKt0HWbN+bNZGT7EZGZmuRwQZmaWywFhpSZVugCzFvizWQE+B2FmZrk8gjAzs1wOCDMzy+WA6MYkjZQ0th33N1DSv+3Adl+T9IX2qsO6jh39zLSyv89K2mU7tzlB0tT2qmFn4oDo3kYCuQEhaUeeBTIQaLf/7LZTyP3MSKrK6VuOzwLbFRC24xwQXYikWknPlix/If12Pl3SVZJmSpov6ThJvYArgQ9Kmi3pg6nvJEm/BW6UVCXpO5KekDRH0ifSfvtJ+r2kJyU9I2lceslvAful/X0n9b2sZPsrSmr7D0nPS/odcGBH/R1Zp1P6mXlC0jRJtwLPAEj6cPrczpb0P03BIelaSfWS5jZ9riR9BtgLmCZpWmo7WdJj6bP6C0n9UvsYSc9JegT4QAXed/cQEZ66yATUAs+WLH8B+BowHfheahsL/C7NfwT4UUn/rwGzgL5peSLwlTTfG6gH9iV70mD/1D4YaACU8/onk11+KLJfNqYC7wHeQfYDYBegf9r+C5X++/NU2c8scAKwBtg3LR8M/AqoTss/Bi5M87unP6vS5/vwtPwSMDjNDwb+COyalr8I/F+gD7AI2D99Nu8Aplb676IrTn7kaPdxd/pzFtl/ypZMiYh1af5k4HBJ56TlAWT/qRYD35D0HmALMBTYM2dfJ6fpqbTcL22/G3BPRKwFkDRlR96QdUszI+LFNH8S2S8TT0gC6AssTevOkzSR7JeVIcAhwJxm+xqV2v+Utu8FPAYcBLwYEX8BkHQz2S9Dtp0cEF3LJrY+LNinZH5D+nMzrf+7rimZF/DvEfGb0g6SPgLUAO+IiI2SXmr2WqXbfzMi/qfZ9p8F/AUby9P88zc5Ir5c2kHSvmSj43dGxHJJP6Plz9+DEfGhZtuPxJ+/duFzEF3Ly8AekgZJ6g2c3kb/VWS/zbfkN8AnJVUDSDpA0q5kI4mlKRzeC+zTwv5+A3ys5LjvUEl7kA37z5LUV9JuwPu3721aN9LaZ/D3wDnpM4Ok3SXtQ3ZYcg2wUtKewKkt7O9x4FhJI9L2u0g6AHgO2FfSfqnfVgFi5fMIogtJP7CvBGYAL5L9R2jNNOBLkmYD38xZfx3Z4agnlY3RG4EzgVuAX0mqB2Y3vU5EvCrpT+lE+f0RcZmkg4HH0hB/NfDhiHhS0u1p24XAw2/mfVvX1ewzs47sl5ymdX+W9BXgt5J6ABuBT0XE45KeAuYCC4A/lexyEnC/pCUR8d402r0t/cIE2Tm1+enw1K8lvQI8Ahxa9HvtjnyrDTMzy+VDTGZmlssBYWZmuRwQZmaWywFhZma5HBBmZpbLAWFmZrkcEGZv0g7eGdes03NAmLVB0n+mO4M+KOm2dBfd6ZK+IekPwCWS9kl3wJ2T/tw7bfuzkntdIWl1+vMESX+UdI+kP0v6SfqymFmn4d98zFohqQ44GziS7P/Lk2Q3RAQYGBHHp36/Am6MiMmSPgb8kOxb6a05muxmcwuBB8huS31nu78Jsx3k31jMWvdu4N6IWBcRq8huT93k9pL5Y4Bb0/xNabu2zIyIBRGxGbitzG3MOowDwqx1amXdmlbWNd3D5vU78Kb7XfXK6dPSsllFOSDMWvcI8H5JfdJda09rod+jwPg0f37aDrIH3LwjzY8Dqku2OVrSvuncwwdLtjHrFHwOwqwVEfFEeuDR02TnCuqBlTldPwPcIOkysrvifjS1/y9wr6SZZLe3Lh11PEb2SM7DyG6Rfk8hb8JsB/lurmZtkNQvIlZL2oXsB/nEiHjyTe7zBLLHsLb1TA+zivEIwqxtkyQdQvZUs8lvNhzMugqPIMzMLJdPUpuZWS4HhJmZ5XJAmJlZLgeEmZnlckCYmVmu/w89fgCcffs8WgAAAABJRU5ErkJggg==
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>
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</div></section><section>
<div class="cell border-box-sizing code_cell rendered">
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<div class="prompt input_prompt">In&nbsp;[17]:</div>
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<div class=" highlight hl-ipython3"><pre><span></span><span class="n">sns</span><span class="o">.</span><span class="n">boxplot</span><span class="p">(</span><span class="n">x</span><span class="o">=</span><span class="s2">&quot;group&quot;</span><span class="p">,</span> <span class="n">y</span><span class="o">=</span><span class="s2">&quot;norm&quot;</span><span class="p">,</span> <span class="n">data</span><span class="o">=</span><span class="n">df</span><span class="p">)</span><span class="o">.</span><span class="n">set_title</span><span class="p">(</span><span class="s1">&#39;AL023803.2&#39;</span><span class="p">)</span>
</pre></div>

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<div class="prompt output_prompt">Out[17]:</div>


<div class="output_text output_subarea output_execute_result">
<pre>Text(0.5,1,&#39;AL023803.2&#39;)</pre>
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<div class="output_png output_subarea ">
<img src="data:image/png;base64,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
"
>
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<div class="cell border-box-sizing code_cell rendered">
<div class="input">
<div class="prompt input_prompt">In&nbsp;[18]:</div>
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    <div class="input_area">
<div class=" highlight hl-ipython3"><pre><span></span><span class="n">cMean</span> <span class="o">=</span> <span class="n">normdf</span><span class="o">.</span><span class="n">loc</span><span class="p">[</span><span class="s1">&#39;AL023803.2&#39;</span><span class="p">][</span><span class="mi">0</span><span class="p">:</span><span class="mi">5</span><span class="p">]</span><span class="o">.</span><span class="n">mean</span><span class="p">()</span>
<span class="n">tMean</span> <span class="o">=</span> <span class="n">normdf</span><span class="o">.</span><span class="n">loc</span><span class="p">[</span><span class="s1">&#39;AL023803.2&#39;</span><span class="p">][</span><span class="mi">5</span><span class="p">:</span><span class="mi">10</span><span class="p">]</span><span class="o">.</span><span class="n">mean</span><span class="p">()</span>
<span class="nb">print</span><span class="p">(</span><span class="n">cMean</span><span class="p">)</span>
<span class="nb">print</span><span class="p">(</span><span class="n">tMean</span><span class="p">)</span>
</pre></div>

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<pre>354.8722544056803
402.20746388364734
</pre>
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</div>
</div>

</div><div class="fragment">
<div class="cell border-box-sizing code_cell rendered">
<div class="input">
<div class="prompt input_prompt">In&nbsp;[19]:</div>
<div class="inner_cell">
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<div class=" highlight hl-ipython3"><pre><span></span><span class="n">diff</span> <span class="o">=</span> <span class="n">tMean</span> <span class="o">-</span> <span class="n">cMean</span>
<span class="n">diff</span>
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<pre>47.335209477967055</pre>
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<p>So the expression level for AL023803.2 in treated samples is about 10% higher. But these averages are <strong>random variables</strong>. They can take many values.</p>
<p>If we repeat the experiment, by sequencing samples from a new batch of patients (or even resequencing the same ones) we get different means. Every time we repeat this experiment, we get a different value of mean difference.</p>

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<p>When comparing measured values we need to be skeptical. How do we know that this difference is due to the treatment? What happens if compare two sets of untreated samples? Will we see a difference this big? Statisticians refer to this scenario as the <strong>null hypothesis</strong>. The name “null” is used to remind us that we are acting as skeptics: we give credence to the possibility that there is no difference.</p>
<p>So what do we do?</p>
<p>Because we do not have access to entire populations of untreated and treated samples, we cannot confidently say just by comparing the mean expression values that a gene is differentialy expressed.</p>
<p>We can perform a simple <strong>permutation test</strong>. Permutation tests take advantage of the fact that if we randomly shuffle the treated and untreated labels for the 10 measurements that we have - then the null is true. So we shuffle the labels, calculate the mean difference and assume that the ensuing distribution approximates the null distribution. Here is how we generate a null distribution by shuffling the data 1,000 times:</p>

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<div class=" highlight hl-ipython3"><pre><span></span><span class="n">normexp</span> <span class="o">=</span> <span class="n">normdf</span><span class="o">.</span><span class="n">loc</span><span class="p">[</span><span class="s1">&#39;AL023803.2&#39;</span><span class="p">]</span>

<span class="n">np</span><span class="o">.</span><span class="n">random</span><span class="o">.</span><span class="n">seed</span><span class="p">(</span><span class="mi">6</span><span class="p">)</span>
<span class="n">means</span> <span class="o">=</span><span class="p">[]</span>

<span class="k">for</span> <span class="n">i</span> <span class="ow">in</span> <span class="nb">range</span><span class="p">(</span><span class="mi">1000</span><span class="p">)</span> <span class="p">:</span>
    <span class="n">aux</span> <span class="o">=</span> <span class="n">np</span><span class="o">.</span><span class="n">random</span><span class="o">.</span><span class="n">permutation</span><span class="p">(</span><span class="n">normexp</span><span class="p">)</span>
    <span class="n">cmean</span> <span class="o">=</span> <span class="n">aux</span><span class="p">[</span><span class="mi">0</span><span class="p">:</span><span class="mi">5</span><span class="p">]</span><span class="o">.</span><span class="n">mean</span><span class="p">()</span>
    <span class="n">tmean</span> <span class="o">=</span> <span class="n">aux</span><span class="p">[</span><span class="mi">5</span><span class="p">:</span><span class="mi">10</span><span class="p">]</span><span class="o">.</span><span class="n">mean</span><span class="p">()</span>
    <span class="n">means</span><span class="o">.</span><span class="n">append</span><span class="p">(</span><span class="n">tmean</span><span class="o">-</span><span class="n">cmean</span><span class="p">)</span>
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<div class=" highlight hl-ipython3"><pre><span></span><span class="n">plt</span><span class="o">.</span><span class="n">hist</span><span class="p">(</span><span class="n">means</span><span class="p">,</span> <span class="n">bins</span> <span class="o">=</span> <span class="mi">20</span><span class="p">)</span>
<span class="n">plt</span><span class="o">.</span><span class="n">axvline</span><span class="p">(</span><span class="n">diff</span><span class="p">,</span> <span class="n">color</span><span class="o">=</span><span class="s1">&#39;k&#39;</span><span class="p">,</span> <span class="n">linestyle</span><span class="o">=</span><span class="s1">&#39;dashed&#39;</span><span class="p">,</span> <span class="n">linewidth</span><span class="o">=</span><span class="mi">2</span><span class="p">)</span>
<span class="n">plt</span><span class="o">.</span><span class="n">axvline</span><span class="p">(</span><span class="o">-</span><span class="n">diff</span><span class="p">,</span> <span class="n">color</span><span class="o">=</span><span class="s1">&#39;k&#39;</span><span class="p">,</span> <span class="n">linestyle</span><span class="o">=</span><span class="s1">&#39;dashed&#39;</span><span class="p">,</span> <span class="n">linewidth</span><span class="o">=</span><span class="mi">2</span><span class="p">)</span>
<span class="n">plt</span><span class="o">.</span><span class="n">show</span><span class="p">()</span>
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<div class=" highlight hl-ipython3"><pre><span></span><span class="n">absmeans</span> <span class="o">=</span> <span class="p">[</span><span class="nb">abs</span><span class="p">(</span><span class="n">x</span><span class="p">)</span> <span class="k">for</span> <span class="n">x</span> <span class="ow">in</span> <span class="n">means</span><span class="p">]</span>
<span class="n">absdiff</span> <span class="o">=</span> <span class="nb">abs</span><span class="p">(</span><span class="n">diff</span><span class="p">)</span>

<span class="n">p</span> <span class="o">=</span> <span class="nb">sum</span><span class="p">(</span><span class="n">absmeans</span> <span class="o">&gt;</span> <span class="n">absdiff</span><span class="p">)</span><span class="o">/</span><span class="nb">len</span><span class="p">(</span><span class="n">absmeans</span><span class="p">)</span>
<span class="n">p</span>
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<pre>0.135</pre>
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<li><strong>Null hypothesis</strong>: there is no significant difference between specified populations, any observed difference being due to sampling or experimental error.</li>
<li>The <strong>p-value</strong> is defined as the probability of obtaining a result equal to or "more extreme" than what was actually observed, when the null hypothesis is true.</li>
<li>The <strong>alternative hypothesis</strong> is considered true if the statistic observed would be an unlikely realization of the null hypothesis according to the p-value.</li>
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<h2 id="Central-Limit-Theorem">Central Limit Theorem<a class="anchor-link" href="#Central-Limit-Theorem">&#182;</a></h2><p>CLT: <strong>When the sample size is large</strong>, the average $\bar{Y}$ of a random sample follows a normal distribution centered at the population average $\mu_{Y}$ and with standard deviation equal to the population standard deviation $\sigma_{Y}$, divided by the square root of the sample size $N$.</p>
<p>We refer to the standard deviation of the distribution of a random variable as the random variable’s standard error.</p>
<p><a href="https://rajeshrinet.github.io/blog/2014/central-limit-theorem/">https://rajeshrinet.github.io/blog/2014/central-limit-theorem/</a></p>

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<p><strong>Population</strong> mean and variance (deviation squred) are parameters defined as:</p>
<p>$$\mu_{Y} = \frac{1}{n}\sum_{i=1}^{n}y_{i}$$
$$\sigma_{Y}^2 = \frac{1}{n}\sum_{i=1}^{n}(y_{i}-\mu_{Y})^{2}$$</p>
<p>where $n$ is the number of elements in population.</p>

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<p>Normal distribution $N(\mu, \sigma)$ is defined with the density function:</p>
<p>$$f(x)=\frac{1}{\sqrt{2\pi\sigma^{2}}}e^{-\frac{\left (x-\mu_{X}  \right )^{2}}{2\sigma^{2}}}$$</p>
<p><img src="images/normal.png" width="550"></p>

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<p>If we subtract a constant from a random variable, the mean of the new random variable shifts by that constant. Mathematically, if $X$ is a random variable with mean $\mu$ and $a$ is a constant, the mean of $X − a$ is $\mu − a$. A similarly intuitive result holds for multiplication and the standard deviation (SD). If $X$ is a random variable with mean $\mu$ and SD $\sigma$, and $a$ is a constant, then the mean and SD of $aX$ are $a\mu$ and $| a | \sigma$ respectively.</p>
<p>Knowing this, the CLT implies that if we take many samples of size $N$, then the quantity:</p>
<p>$$\frac{\bar{Y}-\mu_{Y}}{\sigma_{Y}/\sqrt{N}}$$</p>
<p>is approximated with a normal distribution centered at 0 and with standard deviation 1.</p>

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<p>If $X$ and $Y$ are two random variables independent of each other, then the variance of $X + Y$ is the sum of the
variances $\sigma_{X}^{2} + \sigma_{Y}^{2}$. The sum (or the difference) of normal variables is again normal. <strong>Under the null hypothesis</strong> (when the mean difference is 0), the ratio:</p>
<p>$$\frac{\bar{Y}-\bar{X}}{\sqrt{\frac{\sigma_{Y}^{2}}{N}+\frac{\sigma_{X}^{2}}{M}}}$$</p>
<p>is approximated by a normal distribution centered at 0 and standard deviation 1. Using this approximation makes computing p-values simple because we know the proportion of the distribution under any value. For example, only 5% of these values are larger than 2 (in absolute value).</p>

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<p>However, we can’t claim victory just yet because we don’t know the population standard deviations: $\sigma_{X}$ and $\sigma_{Y}$. These are unknown population parameters, but we can get around this by using the sample standard deviations, call them $s_{X}$ and $s_{Y}$. These are defined as:</p>
<p>$$s_{X}^2 = \frac{1}{M-1}\sum_{i=1}^{M}(X_{i}-\bar{X})^{2}$$
$$s_{Y}^2 = \frac{1}{N-1}\sum_{i=1}^{N}(Y_{i}-\bar{Y})^{2}$$</p>
<p>$M − 1$, $N − 1$: the degrees of freedom.</p>
<p>So we can redefine our ratio as:</p>
<p>$$\frac{\bar{Y}-\bar{X}}{\sqrt{\frac{s_{Y}^{2}}{N}+\frac{s_{X}^{2}}{M}}}$$</p>
<p>The CLT tells us that when $M$ and $N$ are large, this random variable is normally distributed with mean 0 and SD 1.</p>

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<h2 id="The-t-distribution">The t-distribution<a class="anchor-link" href="#The-t-distribution">&#182;</a></h2><p>The CLT relies on large samples, what we refer to as <em>asymptotic</em> results. When the CLT does not apply, there is another option that does not rely on asymptotic results. When the original population from which a random variable, say $Y$, is sampled is normally distributed with mean 0, then we can calculate the distribution of:</p>
<p>$$\sqrt{N}\frac{\bar{Y}-0}{\sigma_{Y}}$$</p>
<p>This is the ratio of two random variables so it is not necessarily normal. The fact that the denominator can be small by chance increases the probability of observing large values. In 1908. William Sealy Gosset, an employee of the Guinness brewing company, deciphered the distribution of this random variable and published a paper under the pseudonym “Student”. The distribution is therefore called Student’s t-distribution.</p>
<p>$$f(t)=\frac{\Gamma(\frac{\nu+1}{2})}{\sqrt{\nu\pi}\Gamma(\frac{\nu}{2})}\left (1+\frac{t^2}{\nu} \right )^{-\frac{\nu+1}{2}}$$</p>
<p>where $\nu$ is the degrees of freedom.</p>

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<p><img src="images/image_11071.jpg" width="450"></p>

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<p>So for small sample sizes we shall be computing that same ratio:</p>
<p>$$\frac{\bar{Y}-\bar{X}}{\sqrt{\frac{s_{Y}^{2}}{N}+\frac{s_{X}^{2}}{M}}}$$</p>
<p>only this time we shall be comparing it to the t-distribution instead of normal. All such tests are usually called Student's t-tests, though strictly speaking that name should only be used if the variances of the two populations are also assumed to be equal; the form of the test used when this assumption is dropped is sometimes called Welch's t-test and that's the one that we'll be implementing.</p>

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<div class=" highlight hl-ipython3"><pre><span></span><span class="k">def</span> <span class="nf">welch_test</span><span class="p">(</span><span class="n">a</span><span class="p">,</span> <span class="n">b</span><span class="p">):</span>
    
    <span class="c1"># pandas.Series.var() returns an unbiased variance estimate, normalized by N-1 by default</span>
    <span class="n">var_a</span> <span class="o">=</span> <span class="n">a</span><span class="o">.</span><span class="n">var</span><span class="p">()</span>
    <span class="n">var_b</span> <span class="o">=</span> <span class="n">b</span><span class="o">.</span><span class="n">var</span><span class="p">()</span>
    
    <span class="n">Na</span> <span class="o">=</span> <span class="nb">len</span><span class="p">(</span><span class="n">a</span><span class="p">)</span>
    <span class="n">Nb</span> <span class="o">=</span> <span class="nb">len</span><span class="p">(</span><span class="n">b</span><span class="p">)</span>

    <span class="c1"># std deviation estimate</span>
    <span class="n">s</span> <span class="o">=</span> <span class="n">np</span><span class="o">.</span><span class="n">sqrt</span><span class="p">(</span><span class="n">var_a</span><span class="o">/</span><span class="n">Na</span> <span class="o">+</span> <span class="n">var_b</span><span class="o">/</span><span class="n">Nb</span><span class="p">)</span>

    <span class="c1"># calculate the t-statistics</span>
    <span class="n">t</span> <span class="o">=</span> <span class="p">(</span><span class="n">a</span><span class="o">.</span><span class="n">mean</span><span class="p">()</span> <span class="o">-</span> <span class="n">b</span><span class="o">.</span><span class="n">mean</span><span class="p">())</span><span class="o">/</span><span class="n">s</span>

    <span class="c1"># degrees of freedom - Welch–Satterthwaite equation, yeah it&#39;s a bit more complicated than Na + Nb - 2</span>
    <span class="n">deg</span> <span class="o">=</span> <span class="p">(((</span><span class="n">var_a</span><span class="p">)</span><span class="o">/</span><span class="n">Na</span> <span class="o">+</span> <span class="p">(</span><span class="n">var_b</span><span class="p">)</span><span class="o">/</span><span class="n">Nb</span><span class="p">)</span><span class="o">**</span><span class="mi">2</span><span class="p">)</span><span class="o">/</span> <span class="p">((</span><span class="n">var_a</span><span class="o">**</span><span class="mi">2</span><span class="p">)</span><span class="o">/</span><span class="p">(</span><span class="n">Na</span><span class="o">**</span><span class="mi">2</span><span class="o">*</span><span class="p">(</span><span class="n">Na</span><span class="o">-</span><span class="mi">1</span><span class="p">))</span> <span class="o">+</span> <span class="p">(</span><span class="n">var_b</span><span class="o">**</span><span class="mi">2</span><span class="p">)</span><span class="o">/</span><span class="p">(</span><span class="n">Nb</span><span class="o">**</span><span class="mi">2</span><span class="o">*</span><span class="p">(</span><span class="n">Nb</span><span class="o">-</span><span class="mi">1</span><span class="p">)))</span>

    <span class="c1"># p-value after comparison with the t     </span>
    <span class="n">p</span> <span class="o">=</span> <span class="mi">2</span><span class="o">*</span><span class="n">stats</span><span class="o">.</span><span class="n">t</span><span class="o">.</span><span class="n">sf</span><span class="p">(</span><span class="n">np</span><span class="o">.</span><span class="n">abs</span><span class="p">(</span><span class="n">t</span><span class="p">),</span> <span class="n">deg</span><span class="p">)</span>
    <span class="k">return</span> <span class="p">(</span><span class="n">p</span><span class="p">)</span>
    
<span class="n">p</span> <span class="o">=</span> <span class="p">[(</span><span class="n">index</span><span class="p">,</span> <span class="n">welch_test</span><span class="p">(</span><span class="n">row</span><span class="o">.</span><span class="n">values</span><span class="p">[</span><span class="mi">0</span><span class="p">:</span><span class="mi">5</span><span class="p">],</span> <span class="n">row</span><span class="o">.</span><span class="n">values</span><span class="p">[</span><span class="mi">5</span><span class="p">:</span><span class="mi">10</span><span class="p">]))</span> <span class="k">for</span> <span class="n">index</span><span class="p">,</span> <span class="n">row</span> <span class="ow">in</span> <span class="n">normdf</span><span class="o">.</span><span class="n">iterrows</span><span class="p">()]</span>
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<div class=" highlight hl-ipython3"><pre><span></span><span class="n">res</span> <span class="o">=</span> <span class="n">pd</span><span class="o">.</span><span class="n">DataFrame</span><span class="p">(</span><span class="n">p</span><span class="p">,</span> <span class="n">columns</span><span class="o">=</span><span class="p">[</span><span class="s1">&#39;gene&#39;</span><span class="p">,</span> <span class="s1">&#39;pval&#39;</span><span class="p">])</span>
<span class="n">res</span> <span class="o">=</span> <span class="n">res</span><span class="o">.</span><span class="n">set_index</span><span class="p">(</span><span class="s1">&#39;gene&#39;</span><span class="p">)</span>
<span class="n">res</span><span class="o">.</span><span class="n">shape</span>
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<pre>(1347, 1)</pre>
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<div class=" highlight hl-ipython3"><pre><span></span><span class="n">res</span><span class="o">.</span><span class="n">head</span><span class="p">(</span><span class="mi">6</span><span class="p">)</span>
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<style scoped>
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      <th>ABBA01031660.1</th>
      <td>0.720978</td>
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      <th>ABBA01031661.1</th>
      <td>0.028195</td>
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      <th>ABBA01031663.1</th>
      <td>0.437817</td>
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      <th>ABBA01031674.1</th>
      <td>0.414137</td>
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<h2 id="Multiple-testing">Multiple testing<a class="anchor-link" href="#Multiple-testing">&#182;</a></h2><ul>
<li>In genomic studies you don't usually fit just one regression model or calculate just one p-value.  You calculate many p-values.</li>
<li>In our simulated dataset, just from chromosome 20 (which is one of the shortest in human genome) we have 1347 genes.</li>
<li>If you use the standard cutoff of 0.05 when calling p-value significant, you'll know that since p-values are uniformly distributed when the null is true, about 1 out of every 20 times you'll still call that result statistically significant, even when there is no true biological effect.</li>
</ul>

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<div class=" highlight hl-ipython3"><pre><span></span><span class="n">np</span><span class="o">.</span><span class="n">random</span><span class="o">.</span><span class="n">seed</span><span class="p">(</span><span class="mi">6</span><span class="p">)</span>
<span class="n">pvals</span> <span class="o">=</span><span class="p">[]</span>

<span class="k">for</span> <span class="n">i</span> <span class="ow">in</span> <span class="nb">range</span><span class="p">(</span><span class="mi">20000</span><span class="p">)</span> <span class="p">:</span>
    <span class="n">firstg</span> <span class="o">=</span> <span class="n">np</span><span class="o">.</span><span class="n">random</span><span class="o">.</span><span class="n">normal</span><span class="p">(</span><span class="mi">32</span><span class="p">,</span> <span class="mi">5</span><span class="p">,</span> <span class="mi">20</span><span class="p">)</span>
    <span class="n">secondg</span> <span class="o">=</span> <span class="n">np</span><span class="o">.</span><span class="n">random</span><span class="o">.</span><span class="n">normal</span><span class="p">(</span><span class="mi">32</span><span class="p">,</span> <span class="mi">5</span><span class="p">,</span> <span class="mi">20</span><span class="p">)</span>
    <span class="n">pval</span> <span class="o">=</span> <span class="n">welch_test</span><span class="p">(</span><span class="n">firstg</span><span class="p">,</span> <span class="n">secondg</span><span class="p">)</span>
    <span class="n">pvals</span><span class="o">.</span><span class="n">append</span><span class="p">(</span><span class="n">pval</span><span class="p">)</span>
    
<span class="n">plt</span><span class="o">.</span><span class="n">hist</span><span class="p">(</span><span class="n">pvals</span><span class="p">,</span> <span class="n">bins</span> <span class="o">=</span> <span class="mi">20</span><span class="p">)</span>
<span class="n">plt</span><span class="o">.</span><span class="n">show</span><span class="p">()</span>
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<div class="prompt input_prompt">In&nbsp;[27]:</div>
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<div class=" highlight hl-ipython3"><pre><span></span><span class="n">res</span><span class="p">[</span><span class="s1">&#39;pval&#39;</span><span class="p">]</span><span class="o">.</span><span class="n">plot</span><span class="o">.</span><span class="n">hist</span><span class="p">(</span><span class="n">bins</span><span class="o">=</span><span class="mi">20</span><span class="p">)</span>
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<pre>&lt;matplotlib.axes._subplots.AxesSubplot at 0x1a1eb558d0&gt;</pre>
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<th>Called significant</th>
<th>Not called significant</th>
<th>Total</th>
</tr>
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<td>Null true</td>
<td>$V$</td>
<td>$n_{0} - V$</td>
<td>$n_{0}$</td>
</tr>
<tr>
<td>Alternative true</td>
<td>$S$</td>
<td>$n_{1} - S$</td>
<td>$n_{1}$</td>
</tr>
<tr>
<td>Total</td>
<td>$R$</td>
<td>$n - R$</td>
<td>$n$</td>
</tr>
</tbody>
</table>
<ul>
<li>$V$ represents the number of type I errors (false positives);</li>
<li>$n_{1} - S$ represents the number of type II errors (false negatives);</li>
<li>$S$ is the number of true positives and $n_{0} - V$ the number of true negatives.</li>
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<p>A multiple testing correction procedure is needed to adjust the statistical confidence measures based on the number of tests performed. Different error rates are defined for this purpose:</p>
<ul>
<li>Family wise error rate:</li>
</ul>
<p>$$FWER = P_{r}\left (V \geq  1  \right ) = 1 - P_{r}\left (V = 0   \right )$$</p>
<p>is the probability of making one or more false discoveries, or type I errors when performing multiple hypotheses tests.</p>
<ul>
<li>False discovery rate:</li>
</ul>
<p>$$FDR=E\left \lfloor \frac{V}{V+S} \right \rfloor$$</p>
<p>is the expected proportion of "discoveries" (rejected null hypotheses) that are false (incorrect rejections).</p>

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<li><p>Suppose 1200 out of 20,000 genes are found significant at 0.05 level (threshold $\alpha = 0.05$).</p>
<ul>
<li>No correction: expect 0.05 * 20,000 = 1000 false positives</li>
<li><span style="color:blue">False Discovery Rate correction</span>: expect 0.05 * 1200 = 60 false positives</li>
<li><span style="color:red">Family Wise Error Rate correction</span>: expect no false positives (probability of having at least one false positive is ≤ 0.05)</li>
</ul>
</li>
<li><p><span style="color:blue">Benjamini-Hochberg correction</span>: the p-values are sorted in increasing order and the i-th p-value is considered significant if it’s less or equal to $\frac{i\alpha}{n}$.</p>
</li>
<li><p><span style="color:red">Bonferroni correction</span>: p-values less or equal to α/n are considered significant.</p>
</li>
</ul>

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<p>After performing Benjamini-Hochberg (FDR) correction:</p>

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<div class=" highlight hl-ipython3"><pre><span></span><span class="n">res</span><span class="o">.</span><span class="n">head</span><span class="p">(</span><span class="mi">6</span><span class="p">)</span>
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<style scoped>
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<table border="1" class="dataframe">
  <thead>
    <tr style="text-align: right;">
      <th></th>
      <th>pval</th>
      <th>qval</th>
      <th>de</th>
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      <th>gene</th>
      <th></th>
      <th></th>
      <th></th>
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      <th>FLRT3</th>
      <td>9.418961e-10</td>
      <td>0.000001</td>
      <td>True</td>
    </tr>
    <tr>
      <th>PLCG1-AS1</th>
      <td>3.296634e-09</td>
      <td>0.000002</td>
      <td>True</td>
    </tr>
    <tr>
      <th>RBM39</th>
      <td>3.591833e-09</td>
      <td>0.000002</td>
      <td>True</td>
    </tr>
    <tr>
      <th>TOP1</th>
      <td>5.383997e-09</td>
      <td>0.000002</td>
      <td>True</td>
    </tr>
    <tr>
      <th>RALGAPB</th>
      <td>5.399923e-09</td>
      <td>0.000001</td>
      <td>True</td>
    </tr>
    <tr>
      <th>RTFDC1</th>
      <td>7.302393e-08</td>
      <td>0.000016</td>
      <td>True</td>
    </tr>
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</table>
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<div class=" highlight hl-ipython3"><pre><span></span><span class="n">res</span><span class="p">[</span><span class="s1">&#39;qval&#39;</span><span class="p">]</span><span class="o">.</span><span class="n">plot</span><span class="o">.</span><span class="n">hist</span><span class="p">(</span><span class="n">bins</span><span class="o">=</span><span class="mi">20</span><span class="p">)</span>
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<pre>&lt;matplotlib.axes._subplots.AxesSubplot at 0x1a1e998358&gt;</pre>
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