diff --git a/conf/igenomes.config b/conf/igenomes.config
index 3fcf3a1c..fe882389 100644
--- a/conf/igenomes.config
+++ b/conf/igenomes.config
@@ -27,7 +27,7 @@ params {
 
             // ROI's
             roi_copgt   = "${params.igenomes_base}/Hsapiens/GRCh38/regions/CMGG_coPGT-M_analyses_ROI_v1.bed"
-            roi_wes     = "${params.igenomes_base}/Hsapiens/GRCh38/regions/CMGG_WES_analysis_ROI_v5.bed"
+            roi_wes     = "${params.igenomes_base}/Hsapiens/GRCh38/regions/CMGG_WES_analysis_ROI_v6.bed"
         }
         "GRCm39" {
             // Genome reference