diff --git a/CHANGELOG.md b/CHANGELOG.md
index ff9770c..cf2ba50 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -2,6 +2,7 @@
 
 ## latest
 
+- Handle calling `initialize()` function of micro simulations written in languages other than Python https://github.com/precice/micro-manager/pull/110
 - Check if initial data returned from the micro simulation is the data that the adaptivity computation requires https://github.com/precice/micro-manager/pull/109
 - Use executable `micro-manager-precice` by default, and stop using the script `run_micro_manager.py` https://github.com/precice/micro-manager/pull/105
 - Make `initialize()` method of the MicroManager class public https://github.com/precice/micro-manager/pull/105
diff --git a/micro_manager/micro_manager.py b/micro_manager/micro_manager.py
index 449f5d1..6472b5f 100644
--- a/micro_manager/micro_manager.py
+++ b/micro_manager/micro_manager.py
@@ -468,18 +468,39 @@ def initialize(self) -> None:
         if hasattr(micro_problem, "initialize") and callable(
             getattr(micro_problem, "initialize")
         ):
-            self._micro_sims_init = True
-
-            # Check if the initialize() method of the micro simulation has any arguments
-            argspec = inspect.getfullargspec(micro_problem.initialize)
-            if len(argspec.args) == 1:
-                is_initial_data_required = False
-            elif len(argspec.args) == 2:
-                is_initial_data_required = True
-            else:
-                raise Exception(
-                    "The initialize() method of the Micro simulation has an incorrect number of arguments."
+            self._micro_sims_init = True  # Starting value before setting
+
+            try:  # Try to get the signature of the initialize() method, if it is written in Python
+                argspec = inspect.getfullargspec(micro_problem.initialize)
+                if (
+                    len(argspec.args) == 1
+                ):  # The first argument in the signature is self
+                    is_initial_data_required = False
+                elif len(argspec.args) == 2:
+                    is_initial_data_required = True
+                else:
+                    raise Exception(
+                        "The initialize() method of the Micro simulation has an incorrect number of arguments."
+                    )
+            except TypeError:
+                self._logger.info(
+                    "The signature of initialize() method of the micro simulation cannot be determined. Trying to determine the signature by calling the method."
                 )
+                # Try to get the signature of the initialize() method, if it is not written in Python
+                try:  # Try to call the initialize() method without initial data
+                    self._micro_sims[0].initialize()
+                    is_initial_data_required = False
+                except TypeError:
+                    self._logger.info(
+                        "The initialize() method of the micro simulation has arguments. Attempting to call it again with initial data."
+                    )
+                    try:  # Try to call the initialize() method with initial data
+                        self._micro_sims[0].initialize(initial_data[0])
+                        is_initial_data_required = True
+                    except TypeError:
+                        raise Exception(
+                            "The initialize() method of the Micro simulation has an incorrect number of arguments."
+                        )
 
         if is_initial_data_required and not is_initial_data_available:
             raise Exception(