From d97a99ccd99ee849429d560072b745f2d658262b Mon Sep 17 00:00:00 2001 From: Antonio Gonzalez Date: Thu, 9 Sep 2021 13:21:41 -0600 Subject: [PATCH] deblur 2021.09 (#3141) --- CHANGELOG.md | 1 + .../deblur2021.09_private_public.png | Bin 0 -> 44309 bytes .../source/processingdata/deblur_2021.09.rst | 78 ++++++++++++++++++ .../doc/source/processingdata/index.rst | 6 +- 4 files changed, 80 insertions(+), 5 deletions(-) create mode 100755 qiita_pet/support_files/doc/source/processingdata/deblur2021.09_private_public.png create mode 100644 qiita_pet/support_files/doc/source/processingdata/deblur_2021.09.rst diff --git a/CHANGELOG.md b/CHANGELOG.md index 6cf0c9aaa..e20d1585a 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -3,6 +3,7 @@ Version 2021.09 --------------- +* Updated the qp-deblur plugin to version 2021.09 addressing a bug in fragment insertion parsing and caching; [more information](https://qiita.ucsd.edu/static/doc/html/processingdata/deblur_2021.09.html). * Double the number of possible connections for the Qiita database: 100 -> 200 simultaneous connections. * Added a new data type: "Job Output Folder" and artifact type definition: "job-output-folder" to initially support admin-only standalone commands in Qiita. * The study listing is now sorted by descending study id and then ascending number of available artifacts. diff --git a/qiita_pet/support_files/doc/source/processingdata/deblur2021.09_private_public.png b/qiita_pet/support_files/doc/source/processingdata/deblur2021.09_private_public.png new file mode 100755 index 0000000000000000000000000000000000000000..247580c2ebe97d425dd942d587de8dcf3fe97f5c GIT binary patch literal 44309 zcmeFZbySq!_cjb7AW|aIDF~>vAR(n6P(VsSxto_P+MDuXBgIP?jaWPJ0~-3yWA@PDT|A3&#ix z3;X069{7YyBr+5H5p{X0<)UV9?&5Cj^cqXa*u}xd-o?h!gxT%2le4A0odAy@4?h?4 z8y6P`=SRG}w*P*B$KJ_;cVd|I3uuJEK~CEl3yY8(^NWp@ltPV#Rq#$;=E*CMl&xuZ zZ}lTo``%bJr`T;sbU?t3oF2Z{)d}xHMM8(wD_i%AQ$*jy`%!M#J)D z>z=^X=D?5g*Csmakr(LT9M#8jpO(z)(xdRB98~&FQb>iDeEZyKax9aAfB(q6FY^$? 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zSi#+PzzjpCvcMMegt%_0BMbiwa@;u^czB@w^#YKOsx5(^BC!d?PL)IMvL3@ayeF(5 z!l<9NrK=b`KVAVDh^?)@fa-(vREXem0%@KQ4b(O^zAY-^gTqHha_lO0p^Ju?)kHW? zya*4NEAzP%59<$XyaEqwVA+=KJO1YkgfQ{YA9rRX*Y>rEz?_1g8%>%zvWcf3B@}}1 zg_m6ZE(TMNXjjgE2ITd99RKOL$A5md^M8CJjm|Kr6cqaR9lRk5F8y;xI+`__. + +It is important to note that this bug only applies to the fragments inserted into the tree, which is +only part of the `deblur reference hit table`. + +How do I know if my study processing had this bug? +---------------------------------------------------- + +The easiest is to check the table summary reported `Number rejected fragments`. If the number is +different between the qp-deblur v1.1.0 and qp-deblur v2021.09 then your study had this bug. To +see the table summary, you need to navigate to the processing graph, click on the +`deblur reference hit table` artifact and see the table summary. + + +Sample counts implications +-------------------------- + +At the time of writing of this documentation Qiita had 978,052 16S deblured private or pubic samples. +In the figure below, we have at different trimming lengths how samples we will recover +based on the minimum number of sequences per sample - this is an important consideration +as we normally need to remove samples below a given threshold for beta diversity +calculations (via rarefaction) or differential abundance testing. + +.. figure:: deblur2021.09_private_public.png + :align: center + +A few conclusions from this plot: + +- The maximum number of samples that we will recover are 6,771 at `Trimming (length: 150)` + and min_seqs of 1,500; which represents a 0.7% increment in private and public samples. +- At all Trimming lengths the curve tends to go up and then down based on min_seq, + which is a common trend seen in rarefacion plots + +How perversive is this bug? +--------------------------- + +For a better assessment we are going to focus on only on the 150 bps trimming length. At +the time of writing of this documentation Qiita had 1,484 16S preparations that have a +150 bps deblur table. Of those: + +- 96.6% of preparations had 0-10% of features lost +- 12.6% had 10-20% of the features lost +- 9.7% 20-30% +- 6.9% 30-40% +- 4.9% 40-50% +- 3.3% 50-60% +- 2.0% 60-70% +- 1.3% 70-80% +- 0.6% 80-90% +- 0.2% 90-100% + +Remember that the percentage reported above is inclusive at the next level, for example +the studies with 40-50% lost are also accounted for at lower levels. + +Additionally, after a Qiita wide review, we did not find a strong patterns among the +studies that were most greatly affected, whether they were from a specific sample type +(according to EMPO 3 category) or target 16S variable region (according to the reported +target_subfragment). + +Reaching out to affected study owners +------------------------------------- + +As you saw in the previous section the effect of the missing fragments depends on the +study, the trimming length and the minimum per sample sequence count. As a +general rule of thumb, as a first analytical pass for meta-analysis for 16S data, we use +5,000 sequences per sample and we prefer 150 base pair trimming. Thus, we directly +contacted all study owners that would recover more than 5% of the samples in their study +(total 24). diff --git a/qiita_pet/support_files/doc/source/processingdata/index.rst b/qiita_pet/support_files/doc/source/processingdata/index.rst index 08f787b05..c2d96a446 100755 --- a/qiita_pet/support_files/doc/source/processingdata/index.rst +++ b/qiita_pet/support_files/doc/source/processingdata/index.rst @@ -164,14 +164,10 @@ Deblurring * **Deblur Final Table** :ref:`[5]` : Contains all the sequences. -Deblur Quality Filtering -~~~~~~~~~~~~~~~~~~~~~~~~ - -Looking for information about debluring? Please see the document here: - .. toctree:: deblur_quality.rst + deblur_2021.09.rst Closed-Reference OTU Picking ----------------------------