You signed in with another tab or window. Reload to refresh your session.You signed out in another tab or window. Reload to refresh your session.You switched accounts on another tab or window. Reload to refresh your session.Dismiss alert
When running ColabFold locally, the template search should produce identical results to those generated by the server. Specifically, the templates returned from the local run should match those returned from the server, given that both use the same MSA and pdb70.m8 input files.
Current Behavior
There is a discrepancy in template search results. The server returns a different set of templates compared to the local run, despite using the same input MSA and pdb70.m8 files.
Steps to Reproduce
I obtained MSA and pdb70.m8 files from a server run.
Ran the local command:
colabfold_batch --templates --local-pdb-path /runtime/databases/mmseqs_2-colabfold/pdb/divided --pdb-hit-file ./server_generated_pdb70.m8 --num-seeds 5 --num-models 5 ./server_generated_msa.a3m ./output_folder
Compared to doing the template search on the server:
colabfold_batch --templates --num-seeds 5 --num-models 5 ./server_generated_msa.a3m ./output_folder
Which gives:
2025-01-14 06:42:50,723 Sequence 0 found no templates
2025-01-14 06:43:04,722 Sequence 1 found templates: ['7vla_R', '7vl8_R', '7o7f_C', '7xa3_R', '6meo_B', '7f1q_R', '7x9y_R', '4n6h_A', '4rwa_B', '8ef5_M', '8efb_R', '7t10_R', '7ul4_A', '7u2l_D', '7sbf_R', '6dde_R', '6vi4_A', '6b73_A', '8f7w_R', '7yit_A']
Given my input, I would expect the server’s results for the template search rather than the local ones.
Any help with understanding why this discrepancy is occurring will be much appreciated!
Thanks
The text was updated successfully, but these errors were encountered:
Expected Behavior
When running ColabFold locally, the template search should produce identical results to those generated by the server. Specifically, the templates returned from the local run should match those returned from the server, given that both use the same MSA and pdb70.m8 input files.
Current Behavior
There is a discrepancy in template search results. The server returns a different set of templates compared to the local run, despite using the same input MSA and pdb70.m8 files.
Steps to Reproduce
I obtained MSA and pdb70.m8 files from a server run.
Ran the local command:
colabfold_batch --templates --local-pdb-path /runtime/databases/mmseqs_2-colabfold/pdb/divided --pdb-hit-file ./server_generated_pdb70.m8 --num-seeds 5 --num-models 5 ./server_generated_msa.a3m ./output_folder
And got this:
2025-01-15 08:31:45,655 Sequence 0 found templates: ['8f7w_A', '8efb_A', '7xa3_A', '7x9y_A', '7vl8_A', '7vla_A', '7o7f_A', '6dde_A', '7sbf_A', '7u2l_A']
2025-01-15 08:31:54,201 Sequence 1 found templates: ['7vla_R', '7o7f_C', '7vl8_R', '6meo_B', '7x9y_R', '7f1q_R', '7xa3_R', '4n6h_A', '7t10_R', '7yit_A', '8ef5_M', '8ef5_R', '4rwa_B', '8efb_R', '4rwa_A', '8f7w_R', '7u2l_D', '7ul4_A', '6b73_A', '7sbf_R']
Compared to doing the template search on the server:
colabfold_batch --templates --num-seeds 5 --num-models 5 ./server_generated_msa.a3m ./output_folder
Which gives:
2025-01-14 06:42:50,723 Sequence 0 found no templates
2025-01-14 06:43:04,722 Sequence 1 found templates: ['7vla_R', '7vl8_R', '7o7f_C', '7xa3_R', '6meo_B', '7f1q_R', '7x9y_R', '4n6h_A', '4rwa_B', '8ef5_M', '8efb_R', '7t10_R', '7ul4_A', '7u2l_D', '7sbf_R', '6dde_R', '6vi4_A', '6b73_A', '8f7w_R', '7yit_A']
Given my input, I would expect the server’s results for the template search rather than the local ones.
Any help with understanding why this discrepancy is occurring will be much appreciated!
Thanks
The text was updated successfully, but these errors were encountered: