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project-details.html
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<!DOCTYPE html>
<html lang="en">
<head>
<meta charset="utf-8">
<meta content="width=device-width, initial-scale=1.0" name="viewport">
<title>Project Details - Vesperr Bootstrap Template</title>
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<h1><a href="index.html">sysbio.<span style="color: #6c63ff">ua</span></a></h1>
</div>
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<li><a class="nav-link scrollto " href="index.html">Home</a></li>
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<h2>Project Details</h2>
<ol>
<li><a href="index.html">Home</a></li>
<li>Project Details</li>
</ol>
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</section><!-- End Breadcrumbs -->
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<h3>Project information</h3>
<ul>
<li><strong>Name</strong>:
<Name></Name>
</li>
<li><strong>Category</strong>: Bioinformatics</li>
<li><strong>Country</strong> Ukraine & Germany</li>
<li><strong>Project date</strong>: 01 March, 2020</li>
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<h2>Project description</h2>
<h5 class="mb-3"><span class="font-weight-bold">Name:</span> The specificity of liver innate immune
response for partial hepatectomy
and laparotomy</h5>
<p>
The liver is the largest solid organ in the body with dual inputs for its blood supply. It
receives 80% of its blood supply from the gut through the portal vein, which is rich in
bacterial products, environment toxins, and food antigens. The remaining 20% is from
vascularization by the hepatic artery. 70% of the cell number or 80% of the liver volume is
composed of hepatocytes that fulfill the metabolic and detoxifying needs of the body.
<p/>
<p>The
remaining cells are made up of nonparenchymal cells, including endothelial cells, stellate
cells, Kupffer cells, and lymphocytes. The liver successfully combines the role of a
biochemical laboratory with the role of a major organ of innate immunity. In a
physiologically relevant state, it eliminates antigens derived from the gastrointestinal
tract, aging and transformed cells and reveals tolerance to their continuous presence. The
liver responses by organ regeneration to partial hepatectomy and by acute phase response to
any kind of body injury not affecting the liver. </p>
<p> Our recent studies revealed the transient
upregulation of interferon a (IFNa) expression during the early hours after partial
hepatectomy. To unravel the potential role of IFNa in liver restoration we addressed the
gene expression in primary hepatocytes isolated from control liver and cultivated with
quasiphysiological dose of IFNa. ISGylation-related genes responsible for post-translational
protein modification were the earliest up-regulated genes. Their expression and regulation
after partial hepatectomy and laparotomy are in the centre of our attention. The unexpected
results raised the question on the role of these genes in acute phase response and the
mechanism of their IFNa independent regulation. The analysis of corresponding genes
promoters with consequent chromatin immunoprecipitation is going on. The function of IFNa
after partial hepatectomy is still an exciting challenge.
</p>
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<h3>sysbio.<span class="accent">ua</span></h3>
<p>We are team of talented scientists making bio research</p>
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<h5> System Biology Group</h5>
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<p>
<a href="http://imbg.org.ua/uk/dept/enzymology/lab_sysbiol/">Institute of Molecular Biology
and Genetics</a>,
</br> 150, Zabolotnoho str., Kyiv, Ukraine, 03143 </p>
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<p>[email protected]</p>
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