diff --git a/README.rst b/README.rst
index 6ac8d94..0370f61 100644
--- a/README.rst
+++ b/README.rst
@@ -157,6 +157,21 @@ mark a model for cleanup:
     class MyModel(models.Model):
         image = models.FileField()
 
+Only cleanup selected fields
+----------------------------
+If you prefer to explicitly configure which fields django-cleanup will handle, you can use the :code:`CLEANUP` setting in your settings.py:
+
+.. code-block:: py
+
+    CLEANUP = {
+        'model.name': {'field1', 'field2'},  # Only clean these fields for this model
+        'other.model': {'field3'}  # Only clean field3 for other.model
+    }
+
+The setting maps model names (in the format "app_label.model_name") to sets of field names that should be cleaned up.
+
+Note that if :code:`CLEANUP` is set and a model or field is not included in the :code:`CLEANUP` setting, its files will not be cleaned up.
+
 How to run tests
 ================
 Install, setup and use pyenv_ to install all the required versions of cPython
diff --git a/pyproject.toml b/pyproject.toml
index 57ab455..9baa06b 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -49,5 +49,6 @@ pythonpath = [".", "src"]
 addopts = ["-v", "--cov-report=term-missing", "--cov=django_cleanup"]
 markers = [
     "cleanup_selected_config: marks test as using the CleanupSelectedConfig app config",
+    "cleanup_settings: marks test as using the CLEANUP django setting",
     "django_storage: change django storage backends"
 ]
diff --git a/src/django_cleanup/cache.py b/src/django_cleanup/cache.py
index 8800c0a..f1751a9 100644
--- a/src/django_cleanup/cache.py
+++ b/src/django_cleanup/cache.py
@@ -2,6 +2,7 @@
 from collections import defaultdict
 
 from django.apps import apps
+from django.conf import settings
 from django.db import models
 from django.utils.module_loading import import_string
 
@@ -28,6 +29,7 @@ def prepare(select_mode):
     if FIELDS:  # pragma: no cover
         return
 
+    config = getattr(settings, "CLEANUP", {})
     for model in apps.get_models():
         if ignore_model(model, select_mode):
             continue
@@ -36,8 +38,11 @@ def prepare(select_mode):
             continue
         opts = model._meta
         for field in opts.get_fields():
-            if isinstance(field, models.FileField):
-                add_field_for_model(name, field.name, field)
+            if not isinstance(field, models.FileField):
+                continue
+            if config and field.name not in config.get(name, []):
+                continue
+            add_field_for_model(name, field.name, field)
 
 
 def add_field_for_model(model_name, field_name, field):
diff --git a/test/conftest.py b/test/conftest.py
index 88015e2..0229892 100644
--- a/test/conftest.py
+++ b/test/conftest.py
@@ -21,6 +21,9 @@ def pytest_collection_modifyitems(items):
 
 @pytest.fixture(autouse=True)
 def setup_django_cleanup_state(request, settings):
+    settings_marker = request.node.get_closest_marker("cleanup_settings")
+    settings.CLEANUP = settings_marker.args[0] if settings_marker else None
+
     for model in cache.cleanup_models():
         suffix = f'_django_cleanup_{cache.get_model_name(model)}'
         post_init.disconnect(None, sender=model,
diff --git a/test/test_all.py b/test/test_all.py
index e5d64d0..a6743ec 100644
--- a/test/test_all.py
+++ b/test/test_all.py
@@ -432,3 +432,47 @@ def test__select_config__replace_file_with_file_ignore(picture):
     new_image_path = os.path.join(django_settings.MEDIA_ROOT, random_pic_name)
     assert product.image.path == new_image_path
 #endregion
+
+
+#region cleanup settings
+@pytest.mark.cleanup_settings({'test.product': {'image'}})
+def test_cleanup_settings_model_included(picture):
+    product = Product.objects.create(image=picture['filename'])
+    assert os.path.exists(picture['path'])
+    random_pic_name = get_random_pic_name()
+    product.image = random_pic_name
+    with transaction.atomic(get_using(product)):
+        product.save()
+    assert not os.path.exists(picture['path'])
+    assert product.image
+    new_image_path = os.path.join(django_settings.MEDIA_ROOT, random_pic_name)
+    assert product.image.path == new_image_path
+
+
+@pytest.mark.cleanup_settings({'test.other_model': {'image'}})
+def test_cleanup_settings_model_excluded(picture):
+    product = Product.objects.create(image=picture['filename'])
+    assert os.path.exists(picture['path'])
+    random_pic_name = get_random_pic_name()
+    product.image = random_pic_name
+    with transaction.atomic(get_using(product)):
+        product.save()
+    assert os.path.exists(picture['path'])  # File should not be cleaned up
+    assert product.image
+    new_image_path = os.path.join(django_settings.MEDIA_ROOT, random_pic_name)
+    assert product.image.path == new_image_path
+
+
+@pytest.mark.cleanup_settings({'test.product': {'other_field'}})
+def test_cleanup_settings_field_excluded(picture):
+    product = Product.objects.create(image=picture['filename'])
+    assert os.path.exists(picture['path'])
+    random_pic_name = get_random_pic_name()
+    product.image = random_pic_name
+    with transaction.atomic(get_using(product)):
+        product.save()
+    assert os.path.exists(picture['path'])  # File should not be cleaned up
+    assert product.image
+    new_image_path = os.path.join(django_settings.MEDIA_ROOT, random_pic_name)
+    assert product.image.path == new_image_path
+#endregion