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JPatrickPett committed Oct 4, 2023
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27 changes: 27 additions & 0 deletions LICENSE.txt
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Copyright (c) 2023, Jan Patrick Pett
All rights reserved.

Redistribution and use in source and binary forms, with or without
modification, are permitted provided that the following conditions are met:

* Redistributions of source code must retain the above copyright notice, this
list of conditions and the following disclaimer.

* Redistributions in binary form must reproduce the above copyright notice,
this list of conditions and the following disclaimer in the documentation
and/or other materials provided with the distribution.

* Neither the name of the copyright holder nor the names of its
contributors may be used to endorse or promote products derived from
this software without specific prior written permission.

THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS"
AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE
IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE
DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT HOLDER OR CONTRIBUTORS BE LIABLE
FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL
DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR
SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER
CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY,
OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE
OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.
15 changes: 15 additions & 0 deletions README.md
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# snp2cell

snp2cell is a package for identifying gene regulation involved in specific traits and cell types.
It combines three elements: (i) GWAS summary statistics, (ii) single cell data and (iii) a base gene regulatory network.
A network propagation approach is used to integrate and overlap different types of scores on the network.
Random permutations of scores are used to evaluate the significance of high scores.
A networkx graph of the gene regulatory network with integrated scores can be used to inspect gene regulatory programs that are linked to the trait (from GWAS) on a per cell type basis.

## Installation

```commandline
mamba create -n snp2cell python<3.12
mamba activate snp2cell
```

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