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MatchEngine V2
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@marriott-er marriott-er released this 16 Sep 16:01
· 670 commits to master since this release
2.0.0
90c44de

The MatchEngine is designed to match cancer patients to genomically driven, precision medicine clinical trials. While this version is a complete re-write from the ground up, it maintains feature parity and most default behaviors from the V1 MatchEngine, as well as integration with the MatchminerAPI (>=V1.0), and MatchminerUI (>=V1.0).

For documentation please see https://matchminer.gitbook.io/matchminer/

CHANGELOG:

  • Add command line flag for matching to individual, or batches of trials
  • Add command line flag for matching based on single sample IDs, or multiple IDs
  • Add command line flag to output digraph visualizations of matching algorithm
  • Adds support by default for new patient genomic criteria including tumor mutational burden, structural variations, and POLE, tobacco, temozolomide, and APOBEC signature statuses
  • Allow for single or batch importing of JSON documents for all data types
  • Introduce asynchronous query behavior
  • Introduce plugin architecture for easy trial configuration/extensibility
  • Trial matching criteria moved to extensible configuration files
  • Fix bug related to reporting trial match reasons
  • Fix sorting bug related to variant level match exclusions
  • Fix bug related to matching on protein wildcard curations
  • Add run_log to track additions, updates, and deletions to individual trials
  • Expand documentation to include tutorials on getting started, trial curation, and engine configuration
  • Add clinical reason(s) to trial match output documents
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