Open MCRA Core 10.1.3 Update

The attached binary file MCRA.CLI.10.1.3.zip contains the compiled version of the
Open MCRA Command Line Interface, which requires the open source
Microsoft .NET Core 8 runtime
to be installed on your computer.

Version 10.1.3 (2024-12-13)

Added

• Update dust exposures module to support chronic and acute exposure calculations (#2045)
• Initial implementation of uploadable PBK models via data module (#2061)
• Implement uploading of SBML models (#2072)

Changed

• Add start and end date of sampling to hbm survey information (#2074)

Fixed

• Inline SVG charts in short report HTML output are not rendered correctly (#2063)

Open MCRA Core 10.1.2 Update

The attached binary file MCRA.CLI.10.1.2.zip contains the compiled version of the
Open MCRA Command Line Interface, which requires the open source
Microsoft .NET Core 8 runtime
to be installed on your computer.

Version 10.1.2 (2024-11-08)

Added

• Implement internal concentration and internal dose (systemic) (#1891)
• Modular design diagram based on action mappings (#2012)
• Implement expression type for kinetic conversion factors (#2019)
• Implement dust exposures module (experimental)
• Implement population alignment methods (#2040)

Changed

• Rename modules: "Human monitoring data" to "HBM occurences" and "Human monitoring analysis" to "HBM analysis" (#2001)
• Remove enum value AbsorptionFactorModel from InternalModelType, add TargetDoseLevelType.Systemic (#2026)
• Rename HBM Occurences module (previously named human monitoring data) to HBM concentrations (#2039)
• Create risks action: rename exposure calculation method "Human monitoring concentrations" to "Human biomonitoring concentrations (#2058)

Fixed

• Uncertainty runs of Cosmos (PBK) fail (#1999)
• Exposure mixtures: return output "Analysis of acute exposures is currently not supported" for network analysis when exposure type is acute (#2005)
• Implementation targetExposureUnit for internal dose and concentration unit (#2018)
• Oxyplots uppertails crash and end with error (#2028)
• Risk value in 'Contribution for individuals at risk' is nominal value (instead of median of all bootstrap runs) (#2031)
• Correction for bodyweight in BiologicalMatrixComparisons (#2035)
• Do not hide columns non-detects and non-quantifications in hbm occurences when data is zero (#2037)
• X-axis of distribution chart of cumulative Risks shows wrong hazard/exposures while the risk metric is set to exposure/hazard (#2038)
• Incorrect reading of exposure route for single value non-dietary exposure data (#2042)
• Compute action for OPEX fails with undefined unit for exposure route (#2050)
• Account for undefined sex property in Busgang method to estimate specific gravity from creatinine (#2051)
• Hazard characterisations output not correctly rendered for systemic (#2052)

Open MCRA Core 10.1.1 Update

The attached binary file MCRA.CLI.10.1.1.zip contains the compiled version of the
Open MCRA Command Line Interface, which requires the open source
Microsoft .NET Core 8 runtime
to be installed on your computer.

Version 10.1.1 (2024-09-20)

Added

• Implement PbkModels module
• Kinetic conversion: implement inverse uniform distribution for conversion factors and test for PARC T6.2.3. pesticides case study (#1992)
• Implement new modules for dust exposure assessment (#2009)
• Add tables and charts for individuals at risk, noy only based on a percentage for the upper tail (#2010)

Changed

• Move compartment to target exposures module
• Exposures module, rename to internal exposures (#1972)
• Separate settings (and behaviour) for kinetic conversion from calculation method settings in hazard characterisations module (#2008)
• Split kinetic models into AbsorptionFactors (KineticModels) and KineticConversionFactors module

Fixed

• Use deterministic substance conversion factors only for replace measurements of focal food/substance scenarios (#1994)
• Correct and refactor load PBK models function of compiled data manager to correctly load PBK model instance records based on scope filter (#2000)
• Correct loading of additional sample properties when loading samples (#2006)

Open MCRA Core 10.1.0 Update

The attached binary file MCRA.CLI.10.1.0.zip contains the compiled version of the
Open MCRA Command Line Interface, which requires the open source
Microsoft .NET Core 8 runtime
to be installed on your computer.

Version 10.1.0 (2024-08-15)

Added

• Create PBK modelng mechanism to allow selection of outputs from multiple compartments (#1927)
• Add install scripts for Python 3.12 to support roadrunner SBML (#1965)
• Update PARC-HBM data format reader to support codebook v2.4 (#1970)

Changed

• Restructure MCRA settings XML format to group settings per module (#581)
• Migrate code base from .NET 6 to .NET 8 (#1833)
• Refactor PBK models and their use in internal exposures and hazard characterisations module (#1933)
• Upgrade R to version 4.4.1 and rtools to 4.4 (#1966)

Fixed

• Cannot convert to target matrix blood when blood is not present as sampling method in HBM data (#1960)
• Output sections are still visible when suppressed in the action settings file (#1969)
• Data formats templates readme text contains invalid URLs (#1979)
• Co-exposure tables fails for aggregate (#1983)
• Human monitoring individuals statistics does not reflect individuals in the further analysis (#1986)

Open MCRA Core 10.0.15 Update

The attached binary file MCRA.CLI.10.0.15.zip contains the compiled version of the
Open MCRA Command Line Interface, which requires the open source
Microsoft .NET Core 6 runtime
to be installed on your computer.

Version 10.0.15 (2024-06-21)

Fixed

• Percentages in risks are not correct (#1962)
• Nominal value used in pies contributions, also in uncertainty run (#1963)

Open MCRA Core 10.0.14 Update

The attached binary file MCRA.CLI.10.0.14.zip contains the compiled version of the
Open MCRA Command Line Interface, which requires the open source
Microsoft .NET Core 6 runtime
to be installed on your computer.

Version 10.0.14 (2024-06-18)

Fixed

• SA Risk steatosis from imazalil seems broken (#1948)
• Show legend MCR plot when exclude privacy sensitive data is selected (#1949)
• Wrong unit for hair in hazard characterisations (#1957)
• Kinetic conversion to blood when blood is not present as sampling method in HBM data (#1959)
• Fix resampling of kinetic conversion factors in uncertainty run

Open MCRA Core 10.0.13 Update

The attached binary file MCRA.CLI.10.0.13.zip contains the compiled version of the
Open MCRA Command Line Interface, which requires the open source
Microsoft .NET Core 6 runtime
to be installed on your computer.

Version 10.0.13 (2024-05-28)

Added

• Add settings tiers for Prospective Dietary CRA (EFSA 2023) (#1924)

Fixed

• Order of exposures in risks percentile table (#1945)
• HBM data gives sequence contains no elements when all body weights are missing (#1946)

Open MCRA Core 10.0.12 Update

The attached binary file MCRA.CLI.10.0.12.zip contains the compiled version of the
Open MCRA Command Line Interface, which requires the open source
Microsoft .NET Core 6 runtime
to be installed on your computer.

Version 10.0.12 (2024-05-21)

Added

• Kinetic conversion for specific biomarkers in hbm analysis (#1827)
• Implementation of SBML generic model (#1910)
• Implement beta distribution for exposure biomarker conversion (#1911)
• Add lod and loq columns to table in hbm data (#1912)
• Adding opex worker-bystander-resident results (#1919)
• Risks, add contributions to risks for individuals for upper distribution (#1936)

Changed

• Combine different urine sampling types (#1880)
• Decouple MCR settings / analysis in different modules (e.g. MCR in Risks and HBM analysis) (#1931)

Fixed

• Output standard action should not report on age dependent hc subgroups when there are no subgroups (#1913)
• PARC T6.2.3 CS Pesticides: fixed uncertainty analysis demonstration (#1916)
• Exclude substances in output of hbm analysis that were not measured (#1917)
• Do not show substances from other matrices in hbm concentrations by substance before conversion (#1922)
• Set settings up-to-date in settings tiers for acute/chronic (#1929)
• MCR plot PFAS Risk action fails (#1930)

Open MCRA Core 10.0.11 Update

The attached binary file MCRA.CLI.10.0.11.zip contains the compiled version of the
Open MCRA Command Line Interface, which requires the open source
Microsoft .NET Core 6 runtime
to be installed on your computer.

Version 10.0.11 (2024-04-12)

Added

• Filtering of hbm data on time points (#1782)
• Running two opex products for compute action single value non-dietary exposures (#1796)
• Specific gravity from creatinine urine adjustment method by Busgang et al. (#1874)
• Option in to skip privacy sensitive outputs in report (#1882)
• New expression type for specific gravity (#1896)
• Add legend for stacked histogram (#1901)
• Implement new option nondetects handling (#1905)

Changed

• Split Busgang urine specific gravity normalisation into age and non-age dependent methods (#1903)
• Draw from censored lognormal using nondetect and nonquantification information (#1904)

Fixed

• Remove hbm analysis option to convert using default value 1 (#1829)
• Limit hbm analysis to active substances only (#1865)

Open MCRA Core 10.0.10 Update

The attached binary file MCRA.CLI.10.0.10.zip contains the compiled version of the
Open MCRA Command Line Interface, which requires the open source
Microsoft .NET Core 6 runtime
to be installed on your computer.

Version 10.0.10 (2024-03-07)

Added

• Data tables for single value non-dietary exposures (#1860)
• Add warning for missing substances in CAG (#1864)

Changed

• MCRA boxplots: adapt for substances with only a few positive measurements (#1888, #1881)

Fixed

• Correct random seed for drawing market shares in market shares calculator
• Use market shares calculated by food conversion instead of the raw market shares
• Hide module points of departure when use data is selected for hazard characterisations (#1887)
• Missing uncertainty results in several Risk exposure output sections
• Apply the complete-cases filter before kinetic conversion and biomarker conversion