Open MCRA Core 10.0.9 Update

The attached binary file MCRA.CLI.10.0.9.zip contains the compiled version of the
Open MCRA Command Line Interface, which requires the open source
Microsoft .NET Core 6 runtime
to be installed on your computer.

Version 10.0.9 (2024-02-27)

Added

• New module single value non-dietary exposures (#1733)
• Implement 'use kinetic conversion factor subgroup' setting (#1868)
• Add exposure and hazard by age section with chart for age dependent HC analyses (#1873)
• Add specific gravity from creatinine adjusted method Carrieri 2001 (#1874)

Changed

• HBM analysis: update biomarker conversion to allow for biomarker conversion subgroups (age/sex) (#1844)
• Move kinetic conversion factors and exposure biomarker conversion to calculator, repair reproducability (#1870)

Fixed

• Kernel calculation in R for violin plots fails when vector contains infinities (#1869)
• Human monitoring analysis settings: order of settings is incorrect (#1876)
• Do not support multiple urines in analysis, but do allow multiple urines in HBM data (#1877)
• Fix market shares calculation for chronic exposure assessments (#1878)

Open MCRA Core 10.0.8 Update

The attached binary file MCRA.CLI.10.0.8.zip contains the compiled version of the
Open MCRA Command Line Interface, which requires the open source
Microsoft .NET Core 6 runtime
to be installed on your computer.

Version 10.0.8 (2024-02-12)

Added

• Implement data format and use of kinetic conversion factors sub-groups (#1805)
• Extend HBM biomarker conversion calculator with possibility for summation of multiple measured substances (#1837)

Changed

• HBM analysis: change order of settings in output summary (#1839)
• Change all caption upper summaries, use specified percentage (#1859)

Fixed

• ExposurePathway Oral enum was used instead of Dietary enum when running the reverse kinetic model (from internal to external) (#1850)
• Upper MCR plot fix, MCR plots for RPF weighted and sum of ratios corrected x-axes (#1854)
• Update food conversion calculator to be a bit more permissive for market shares not adding up to 100% (allow for minor differences)
• Oxyplot individuals don't render, add uncertainty substances (#1862, #1866, #1867)

Open MCRA Core 10.0.7 Update

The attached binary file MCRA.CLI.zip contains the compiled version of the Open MCRA Command Line Interface, which requires the open source Microsoft .NET Core 6 runtime to be installed on your computer.

Version 10.0.7 (2024-02-02)

Added

• Implement uncertainty distribution kinetic conversion factors (#1845)

Changed

• Move body weight imputation to hbm analysis (#1807)

Fixed

• HBM complete samples should filter on individual day (#1835)
• Violin plots are missing (#1847)

Open MCRA Core 10.0.6 Update

The attached binary file MCRA.CLI.zip contains the compiled version of the Open MCRA Command Line Interface, which requires the open source Microsoft .NET Core 6 runtime to be installed on your computer.

Version 10.0.6 (2024-01-26)

Added

• Add a first implementation of the exposure biomarker conversion module and its use in the HBM analysis action (#1743)
• Summary section on substance contributions for rpf-weighted cumulative risks (#1769)
• Add boxplots for contributions to substances of individuals (#1774)

Changed

• Update risks and HBM analysis calculator to allow risks on external exposures derived from HBM (#1820)
• More insightful sample columns for hbm data (#1821)
• Removed analytical methods data section from report (too large) (#1624)

Fixed

• Improve loading speed frontend for large concentration datasets (#1542)
• Wrong percentiles cause exception message in boxplot of hbm data (#1825)
• PDF fails to render due to large AnalyticalMethods section (#1831)

Open MCRA Core 10.0.5 Update

The attached binary file MCRA.CLI.zip contains the compiled version of the Open MCRA Command Line Interface, which requires the open source Microsoft .NET Core 6 runtime to be installed on your computer.

Version 10.0.5 (2023-12-21)

Changed

• Additional changes for MCR analysis in risks module (#1784)

Fixed

• Description for boxplots for full and positives only of hbm samples per substance (#1812)
• Total number non-analysed hbm samples reported incorrectly (#1813)
• Flip description individual - individual days for hbm samples table (#1818)

Open MCRA Core 10.0.4 Update

The attached binary file MCRA.CLI.zip contains the compiled version of the Open MCRA Command Line Interface, which requires the open source Microsoft .NET Core 6 runtime to be installed on your computer.

Version 10.0.4 (2023-12-18)

Added

• Add general information columns (publication title e.o.) to RPF table (#1772)
• Allow for hazard-characterizations to vary as function of a covariate: example age-dependent HBM-GV for PFAS (#1778)
• Implement MCR analysis in risks module (#1784)

Changed

• Rename MarginOfExposure and HazardIndex of type-definition/enum RiskMetricType (#1705)
• Update HBM kinetic conversion to automatically express external exposures per kg bodyweight (#1804)

Fixed

• Update load data method in hazard characterisations module to filter on active substances when specified (#1799)
• Empty column header in sample time point sheets of HBM basic codebook cause nullref exception (#1800)
• Remove not-null/required constraint for sampling dates in HBM data (#1806)

Open MCRA Core 10.0.3 update

The attached binary file MCRA.CLI.zip contains the compiled version of the Open MCRA Command Line Interface, which requires the open source Microsoft .NET Core 6 runtime to be installed on your computer.

Version 10.0.3 (2023-12-01)

Added

• Kinetic conversion models for metabolites (#1683)
• Add support of reverse metabolite to parent (external oral exposure) conversion in HBM analysis module (#1727)
• Add option to derive hazard characterisations from BMDLs and a switch option between parameteric and bootstrapped BMD uncertainty bounds (#1788)
• HBM data exclude substance - sampling method combinations (#1795)
• Show number of non-analysed samples in hbm data samples summary (#1797)

Changed

• Update risk calculation to explicitly align exposure and hazard units (#1761)
• Hide uncertainty columns in hazard and rpf output when resamplerpf is not selected (#1773)
• Restructure risk section (#1785)

Fixed

• Correct units display in BiologicalMatrixComparisons and add check for single matrix (#1760)
• Correct units administration in exposure mixtures module (#1763)
• Only include complete analysed samples and skip blanks (#1792)
• Default target surface level for hbm kinetic conversion set to internal

Open MCRA Core 10.0.2 update

The attached binary file MCRA.CLI.zip contains the compiled version of the Open MCRA Command Line Interface, which requires the open source Microsoft .NET Core 6 runtime to be installed on your computer.

Version 10.0.2 (2023-10-26)

Added

• New table risk ratios, improved output (descriptions and view)
• Add number of individuals field to risks safety chart and risks by substance overview section

Changed

• Include expression type (if relevant) when rendering axis title of exposure versus hazard plots
• Update HBM analysis module to filter individual/days with missing substance concentrations (also accounting for multiple matrices)

Fixed

• Stack overflow exception reading an Excel file with many empty rows (#1767)
• Key not found exception: add check on Hazard characterisation ID when loading HC-uncertain data

Open MCRA Core v10.0.1

Open MCRA Core version 10.0.1 update

The attached binary file MCRA.CLI.zip contains the compiled version of the Open MCRA Command Line Interface, which requires the open source Microsoft .NET Core 6 runtime to be installed on your computer.

Version 10.0.1 (2023-10-23)

Added

• MCRA commander must be able to run action loops (#1348)
• Bootstrap hbm monitoring data (#1405)
• Add support for PARC-HBM data for occupational exposure (#1578)
• Implement PARC-HBM data format reader to support codebook v2.3 (#1649)
• Basic implementation kinetic conversion factors (#1658, #1660)
• Implement new HBM units (#1678)
• Implement kinetic conversion factors (#1695)
• Exclude substances from urine or blood normalisation - standardisation (#1659, #1703)
• Add biological matrix and expression type to points of departure (POD) data table (#1724)
• Update HBM analysis module with univariate outlier detection based on interquartile range (#1728)
• Implement risks calculation for multiple targets (#1740)
• Add median of assessment factors distribution to output (#1741)
• Hazard characterisations uncertain (#1742)
• Add HBM risk-drivers summary sections for cumulative (RPF-weighted) HBM analyses (#1745)

Changed

• Apply mixed HBM units logic (normal, normalised or standardised) to biological matrix concentrations (#1524)
• Update names of risk metric type options in risks module (#1573)
• Remove action tiers from module definitions to tier/template files per tier (#1673)
• Create separate matrix selection settings for kinetic models and HBM analysis (#1684)
• Generalize exposure matrix to allow substance-target combinations as rows (#1706)
• Consistent short concentration units in output of HBM (#1752)

Fixed

• CLI and Web interface give different results for HBM sampling method (#1605)
• Wrong thousands separator in number of Monte Carlo iterations (#1645)
• Use correct hazard units for HBM data (#1662)
• Sort order in some CSV output tables differs between runs (#1682)
• Import HBM data should read in correct biological matrix (#1685)
• Crammed lines in boxplot for concentration by substances (#1690)
• Convert to single target for hazard characterisations (#1696)
• When the actiontype is changed a null reference exception occurs (#1707)
• Echo additional assessment factor in output (#1711)
• Use of POD with uncertainty sets returns "Faulted" error (#1712)
• Recalculate stddevs in ExposureMixtures when a subset is taken from the original exposure matrix (based on exposure limit) (#1720)
• Exclude substances from creatinine standardisation (#1722)
• Update resampling mechanism in RPF module to draw RPFs using uncertainty sets (#1751)

Open MCRA Core 10 public release

First release of the Open MCRA Core version 10 software.

The attached binary file MCRA.CLI.zip contains the compiled version of the Open MCRA Command Line Interface, which requires the open source Microsoft .NET Core 6 runtime to be installed on your computer.