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Open MCRA Core v10.0.1
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@MarcoVanLenthe MarcoVanLenthe released this 24 Oct 06:27
· 518 commits to main since this release
v10.0.1
124f58a

Open MCRA Core version 10.0.1 update

The attached binary file MCRA.CLI.zip contains the compiled version of the Open MCRA Command Line Interface, which requires the open source Microsoft .NET Core 6 runtime to be installed on your computer.

Version 10.0.1 (2023-10-23)

Added

  • MCRA commander must be able to run action loops (#1348)
  • Bootstrap hbm monitoring data (#1405)
  • Add support for PARC-HBM data for occupational exposure (#1578)
  • Implement PARC-HBM data format reader to support codebook v2.3 (#1649)
  • Basic implementation kinetic conversion factors (#1658, #1660)
  • Implement new HBM units (#1678)
  • Implement kinetic conversion factors (#1695)
  • Exclude substances from urine or blood normalisation - standardisation (#1659, #1703)
  • Add biological matrix and expression type to points of departure (POD) data table (#1724)
  • Update HBM analysis module with univariate outlier detection based on interquartile range (#1728)
  • Implement risks calculation for multiple targets (#1740)
  • Add median of assessment factors distribution to output (#1741)
  • Hazard characterisations uncertain (#1742)
  • Add HBM risk-drivers summary sections for cumulative (RPF-weighted) HBM analyses (#1745)

Changed

  • Apply mixed HBM units logic (normal, normalised or standardised) to biological matrix concentrations (#1524)
  • Update names of risk metric type options in risks module (#1573)
  • Remove action tiers from module definitions to tier/template files per tier (#1673)
  • Create separate matrix selection settings for kinetic models and HBM analysis (#1684)
  • Generalize exposure matrix to allow substance-target combinations as rows (#1706)
  • Consistent short concentration units in output of HBM (#1752)

Fixed

  • CLI and Web interface give different results for HBM sampling method (#1605)
  • Wrong thousands separator in number of Monte Carlo iterations (#1645)
  • Use correct hazard units for HBM data (#1662)
  • Sort order in some CSV output tables differs between runs (#1682)
  • Import HBM data should read in correct biological matrix (#1685)
  • Crammed lines in boxplot for concentration by substances (#1690)
  • Convert to single target for hazard characterisations (#1696)
  • When the actiontype is changed a null reference exception occurs (#1707)
  • Echo additional assessment factor in output (#1711)
  • Use of POD with uncertainty sets returns "Faulted" error (#1712)
  • Recalculate stddevs in ExposureMixtures when a subset is taken from the original exposure matrix (based on exposure limit) (#1720)
  • Exclude substances from creatinine standardisation (#1722)
  • Update resampling mechanism in RPF module to draw RPFs using uncertainty sets (#1751)
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